{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:43:48Z","timestamp":1790862228690,"version":"4.1.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The First Clinical Medical College of Jinan University Nursing scientific research","award":["2022209"],"award-info":[{"award-number":["2022209"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>The Surviving Sepsis Campaign (SSC) believed that early identification of septic shock, aggressive fluid resuscitation and maintenance of effective perfusion pressure should be carried out. However, some of the current research focused on a single death factor for sepsis patients, based on a limited sample, and the research results of the relationship between comorbidities and sepsis related death also have some controversies.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Method<\/jats:title><jats:p>Therefore, our study used data from a large sample of 9,544 sepsis patients aged 18\u201385 obtained from the MIMIC-IV database, to explore the risk factors of death in patients with sepsis. We used the general clinical information, organ dysfunction scores, and comorbidities to analyze the independent risk factors for death of these patients.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>The death group had significantly higher organ dysfunction scores, lower BMI, lower body temperature, faster heart rate and lower urine-output. Among the comorbidities, patients suffering from congestive heart failure and liver disease had a higher mortality rate.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>This study helps to identify sepsis early, based on a comprehensive evaluation of a patient\u2019s basic information, organ dysfunction scores and comorbidities, and this methodology could be used for actual clinical diagnosis in hospitals.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0287254","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T18:46:22Z","timestamp":1702579582000},"page":"e0287254","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of pathogenic factors on the death rate of sepsis patients"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6638-2070","authenticated-orcid":true,"given":"Luwei","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingran","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2237-8771","authenticated-orcid":true,"given":"Jun","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"pone.0287254.ref001","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11908-010-0122-3","article-title":"Early identification of sepsis","volume":"12","author":"MD Gonsalves","year":"2010","journal-title":"Curr Infect Dis Rep"},{"key":"pone.0287254.ref002","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"M Bauer","year":"2016","journal-title":"JAMA"},{"key":"pone.0287254.ref003","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1186\/cc3885","article-title":"Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study","volume":"9","author":"M Christ-Crain","year":"2005","journal-title":"Crit Care"},{"key":"pone.0287254.ref004","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"D Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"pone.0287254.ref005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study","volume":"395","author":"K Rudd","year":"2020","journal-title":"Lancet"},{"key":"pone.0287254.ref006","first-page":"207","article-title":"Epidemiology of severe sepsis around the world","volume":"6","author":"DC Angus","year":"2006","journal-title":"Endocr Metab Immune"},{"key":"pone.0287254.ref007","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/SHK.0b013e31828fad61","article-title":"Sepsis as a global health problem-why we need a global sepsis alliance","volume":"39","author":"SN Stehr","year":"2013","journal-title":"Shock"},{"key":"pone.0287254.ref008","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01326","article-title":"The immunopathogenesis of sepsis","volume":"420","author":"J. 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