{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:26:51Z","timestamp":1772231211913,"version":"3.50.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Science Foundation of China","award":["No.31960693, No.31760723"],"award-info":[{"award-number":["No.31960693, No.31760723"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Exploring the expression characteristics of Fc\u03bcR in small intestinal lymph nodes of bactrian camels can lay the foundation for further revealing the function of Fc\u03bcR. The Fc\u03bcR expression characteristics were systematically analysed by using prokaryotic expression, antibody preparation, immunohistochemical staining and statistical analysis. Fc\u03bcR positive cells were mainly located in the lymphoid follicles and their numbers decreased in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes, and the number of positive cells was statistically significant between different intestinal segments (P&lt;0.05). The Fc\u03bcR is expressed in lymphoid follicular B cells, which not only facilitates the body\u2019s ability to regulate secretory IgM levels, but also acts as a local immune defence barrier. The small intestine has dual functions of immune tolerance and immune response, the proximal part mainly focuses on immune tolerance, and the distal part mainly focuses on immune response. This distribution ensures the unity of the duodenal absorption and immune defence, and also significantly increases the efficiency of the entire small intestine, which is why the number of Fc\u03bcR positive cells decreases in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes.<\/jats:p>","DOI":"10.1371\/journal.pone.0287329","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T17:48:21Z","timestamp":1689875301000},"page":"e0287329","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Distribution characteristics of Fc\u03bcR positive cells in small intestinal lymph nodes of Bactrian camel"],"prefix":"10.1371","volume":"18","author":[{"given":"Xie","family":"Fei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian 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