{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:25:32Z","timestamp":1780363532174,"version":"3.54.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571010"],"award-info":[{"award-number":["81571010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Clinical Research of Shandong University","award":["2020SDUCRCA005"],"award-info":[{"award-number":["2020SDUCRCA005"]}]},{"name":"Shandong University Graduate Education and Teaching excellent achievement training program","award":["ZY2019004"],"award-info":[{"award-number":["ZY2019004"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701008"],"award-info":[{"award-number":["81701008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Shandong Province, China","award":["2019GSF108187"],"award-info":[{"award-number":["2019GSF108187"]}]},{"name":"Undergraduate Teaching Reform and Research Project of Shandong University Cheeloo Medical College","award":["qlyxjy-202027"],"award-info":[{"award-number":["qlyxjy-202027"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate transverse maxillomandibular discrepancy and dental compensation in first molar areas in 7- to 9-year-old children with skeletal Class III malocclusion without posterior crossbite using cone-beam computed tomography (CBCT).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The sample of this retrospective study consisted of 60 children (7 to 9 years old), who were divided into the skeletal Class III malocclusion group (study group, skeletal Class III malocclusion without posterior crossbite, N = 31) and the Class I occlusion group (control group, Class I occlusion with one or two impacted teeth, N = 30). CBCT data were obtained from the database of the Department of Radiology of Hospital of Stomatology, Shandong University. For three-dimensional reconstruction of the head, the dental arch width, basal bone width, and buccolingual inclination angle were measured using MIMICS 21.0 software. Independent-sample <jats:italic>t<\/jats:italic> tests were used to compare the two groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The mean age of the children was 8.18\u00b10.83years. The width of the maxillary basal bone was significantly smaller in the skeletal Class III malocclusion group (59.75 \u00b1 3.14 mm) than in the Class I occlusion group (62.39 \u00b1 3.01 mm) (<jats:italic>P<\/jats:italic> &lt; 0.01). The mandibular basal bone width was significantly larger in the skeletal Class III malocclusion group (60.00 \u00b1 2.56 mm) than in the Class I occlusion group (58.19 \u00b1 2.42 mm) (<jats:italic>P<\/jats:italic> &lt; 0.01). The difference in the width of the maxillary and mandibular bases in the skeletal Class III malocclusion group (\u20130.25 \u00b1 1.73 mm) was significantly different from that in the Class I occlusion group (4.20 \u00b1 1.25 mm) (<jats:italic>P<\/jats:italic> &lt; 0.01). However, there was no significant difference in the upper or lower dental arch width between the two groups (<jats:italic>P<\/jats:italic> &gt; 0.05). The buccal inclination of the maxillary molars in the skeletal Class III malocclusion group (31.4\u00b0 \u00b1 8.9\u00b0) was significantly higher than that in the Class I occlusion group (17.64\u00b0 \u00b1 7.3\u00b0) (<jats:italic>P<\/jats:italic> &lt; 0.01), as was the lingual inclination angle of mandibular molars (45.24\u00b0 \u00b1 8.3\u00b0 vs. 37.96\u00b0 \u00b1 10.18\u00b0; <jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Transverse maxillary and mandibular discrepancies in the posterior area and transverse dental compensation were found in the early mixed dentition of patients with skeletal Class III malocclusion without posterior crossbite. This suggests that even in the absence of posterior crossbite, maxillary expansion can be attempted to correct the maxillomandibular transverse discrepancy.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0287343","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T18:09:19Z","timestamp":1686852559000},"page":"e0287343","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["A study of transverse maxillomandibular discrepancy and dental compensation in early mixed dentition with skeletal Class III malocclusion without posterior 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Class III malocclusions: challenges and solutions.","volume":"10","author":"E Zere","year":"2018","journal-title":"Clin Cosmet Investig Dent"},{"issue":"4","key":"pone.0287343.ref002","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0002-9416(86)90052-7","article-title":"The morphology of the potential Class III skeletal pattern in the growing child.","volume":"89","author":"S Williams","year":"1986","journal-title":"Am J Orthod"},{"issue":"1","key":"pone.0287343.ref003","first-page":"7","article-title":"Components of class III malocclusion in juveniles and adolescents.","volume":"56","author":"EC Guyer","year":"1986","journal-title":"Angle Orthod."},{"issue":"2","key":"pone.0287343.ref004","doi-asserted-by":"crossref","first-page":"171.e1","DOI":"10.1016\/j.ajodo.2005.07.031","article-title":"Craniofacial changes in Class III malocclusion as related to skeletal and dental maturation.","volume":"132","author":"T Baccetti","year":"2007","journal-title":"Am J Orthod 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Acta Odontol Scand."},{"issue":"4","key":"pone.0287343.ref012","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ajodo.2004.03.023","article-title":"Comparison between traditional 2-dimensional cephalometry and a 3-dimensional approach on human dry skulls.","volume":"126","author":"GL Adams","year":"2004","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"pone.0287343.ref013","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1053\/j.sodo.2008.09.004","article-title":"3D Diagnosis and treatment planning in orthodontics.","volume":"15","author":"WJ Harrell","year":"2009","journal-title":"Semin in Orthod"},{"issue":"3","key":"pone.0287343.ref014","first-page":"300","article-title":"Cone-beam computed tomography transverse analysis.","volume":"142","author":"RM Miner","year":"2012","journal-title":"Part I: Normative data. 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Wilson","year":"1911","journal-title":"Philadelphia,Pa: Lea & Febiger"},{"issue":"6","key":"pone.0287343.ref031","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0889-5406(03)00630-9","article-title":"Transverse molar movements during growth.","volume":"124","author":"S Marshall","year":"2003","journal-title":"Am J Orthod Dentofacial Orthop"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0287343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T18:09:51Z","timestamp":1686852591000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0287343"}},"subtitle":[],"editor":[{"given":"Claudia Trindade","family":"Mattos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0287343","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]}}}