{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:48:04Z","timestamp":1777729684233,"version":"3.51.4"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Introduction<\/jats:title><jats:p>Among individuals \u2265 65 years old, aortic stenosis is highly prevalent and the number of cases is expected to increase in the coming decades, due to the increased life expectancy. Nevertheless, the actual aortic stenosis burden is not well known in population settings and the impact of aortic stenosis on quality of life has not been studied. The aim of this study was to evaluate aortic stenosis impact on health-related quality of life in patients &gt; 65 years old.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>An epidemiological case-control study was carried out to compare quality of life in patients \u226565 years old with severe symptomatic aortic stenosis. Demographical and clinical information was prospectively obtained and quality of life information was collected with the Short Form Health Survey_v2 (SF-12) questionnaire. The association between quality of life and aortic stenosis was determined using multiple logistic regression models.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>Patients with severe aortic stenosis self-perceived worse quality of life on all dimensions and summary components of the SF-12 questionnaire. In the final multiple logistic regression model a significant inverse association was observed between the dimensions \u2018physical role\u2019 and \u2018social role\u2019 (p = 0.002 and p = 0.005) and an association close to significance with \u2018physical role\u2019 (p = 0.052) of the SF-12 questionnaire.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>The use of quality of life scales allows the assessment of the impact of aortic stenosis on quality of life and may improve the therapeutic approach to severe aortic stenosis, providing evidence for patient\u2010centered care.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0287508","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T20:34:52Z","timestamp":1687379692000},"page":"e0287508","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of severe aortic stenosis on quality of life"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-3847","authenticated-orcid":true,"given":"Juan Manuel","family":"Gracia Baena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep Ramon","family":"Marsal Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Llorca Carde\u00f1osa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-7895","authenticated-orcid":true,"given":"Imma","family":"Calaf Vall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Zielonka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Godoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"pone.0287508.ref001","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic stenosis","volume":"2","author":"BR Lindman","year":"2016","journal-title":"Nat Rev Dis Prim"},{"key":"pone.0287508.ref002","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1177\/2047487312451238","article-title":"Prevalence of calcific aortic valve disease in the elderly and associated risk factors: a population-based study in a Mediterranean area","volume":"20","author":"I Ferreira-Gonz\u00e1lez","year":"2013","journal-title":"Eur J Prev Cardiol"},{"key":"pone.0287508.ref003","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","article-title":"Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study","volume":"62","author":"RLJ Osnabrugge","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 4","key":"pone.0287508.ref004","doi-asserted-by":"crossref","first-page":"iv7","DOI":"10.1136\/heartjnl-2012-302395","article-title":"Degenerative calcific aortic stenosis: a natural history","volume":"98","author":"B Iung","year":"2012","journal-title":"Heart"},{"key":"pone.0287508.ref005","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.ijcard.2014.08.053","article-title":"The prevalence of aortic stenosis in the elderly in Iceland and predictions for the coming decades: The AGES\u2013Reykjav\u00edk study","volume":"176","author":"R Danielsen","year":"2014","journal-title":"Int J Cardiol"},{"key":"pone.0287508.ref006","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jacc.2014.02.536","article-title":"2014 AHA\/ACC Guideline for the Management of Patients With Valvular Heart Disease","volume":"63","author":"RA Nishimura","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"pone.0287508.ref007","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"A Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"pone.0287508.ref008","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/eurheartj\/ehs466","article-title":"Venn diagrams in cardiovascular disease: the Heart Team concept","volume":"35","author":"DR Holmes","year":"2014","journal-title":"Eur Heart J"},{"key":"pone.0287508.ref009","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"38","author":"H Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"pone.0287508.ref010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1051\/ject\/201345008","article-title":"Quality-of-Life measures for cardiac surgery practice and research: a review and primer","volume":"45","author":"PJ Tully","year":"2013","journal-title":"J Extra Corpor Technol"},{"key":"pone.0287508.ref011","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/jama.1995.03520250075037","article-title":"Linking Clinical Variables With Health-Related Quality of Life","volume":"273","author":"IB Wilson","year":"1995","journal-title":"JAMA"},{"key":"pone.0287508.ref012","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1510\/icvts.2011.276311","article-title":"Quality of life after cardiac surgery: underresearched research","volume":"13","author":"L Noyez","year":"2011","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"pone.0287508.ref013","first-page":"771","article-title":"[The Spanish version of the SF-36 Health Survey (the SF-36 health questionnaire): an instrument for measuring clinical results]","volume":"104","author":"J Alonso","year":"1995","journal-title":"Med Clin (Barc)"},{"issue":"Suppl 1","key":"pone.0287508.ref014","doi-asserted-by":"crossref","first-page":"S383","DOI":"10.1002\/acr.20541","article-title":"Adult measures of general health and health-related quality of life: Medical Outcomes Study Short Form 36-Item (SF-36) and Short Form 12-Item (SF-12) Health Surveys, Nottingham Health Profile (NHP), Sickness Impact Profile (SIP), Medical Outcomes Study Sh.","volume":"63","author":"L Busija","year":"2011","journal-title":"Arthritis Care Res (Hoboken)."},{"key":"pone.0287508.ref015","first-page":"1171","article-title":"Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project","volume":"51","author":"B Gandek","year":"1998","journal-title":"International Quality of Life Assessment. J Clin Epidemiol"},{"key":"pone.0287508.ref016","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/hrt.2003.013995","article-title":"Comparison of the short form (SF)-12 health status instrument with the SF-36 in patients with coronary heart disease","volume":"90","author":"J. Muller-Nordhorn","year":"2004","journal-title":"Heart"},{"key":"pone.0287508.ref017","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12471-012-0364-9","article-title":"Quality of life among patients with severe aortic stenosis","volume":"21","author":"MWA van Geldorp","year":"2013","journal-title":"Netherlands Hear J"},{"key":"pone.0287508.ref018","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.jacc.2021.09.864","article-title":"Contemporary Management of Severe Symptomatic Aortic Stenosis","volume":"78","author":"M Eug\u00e8ne","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"pone.0287508.ref019","doi-asserted-by":"crossref","first-page":"e015975","DOI":"10.1161\/JAHA.119.015975","article-title":"Priorities for Patient-Centered Research in Valvular Heart Disease: A Report From the National Heart, Lung, and Blood Institute Working Group","volume":"9","author":"BR Lindman","year":"2020","journal-title":"J Am Heart Assoc."},{"key":"pone.0287508.ref020","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1093\/eurheartj\/ehs109","article-title":"Guidelines on the management of valvular heart disease (version 2012).","volume":"33","author":"A Vahanian","year":"2012","journal-title":"Eur Heart J"},{"key":"pone.0287508.ref021","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.rce.2020.01.010","article-title":"Factores de riesgo y comorbilidades asociadas a la estenosis a\u00f3rtica grave: estudio de casos y controles.","volume":"221","author":"JM Gracia Baena","year":"2021","journal-title":"Rev Clin Esp"},{"key":"pone.0287508.ref022","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1510\/icvts.2010.240085","article-title":"Quality-of-life in octogenarians one year after aortic valve replacement with or without coronary artery bypass surgery","volume":"11","author":"S Folkmann","year":"2010","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"pone.0287508.ref023","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/j.jacc.2012.01.035","article-title":"Serial change in health-related quality of life over 1 year after transcatheter aortic valve implantation: predictors of health outcomes","volume":"59","author":"TA Fairbairn","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"pone.0287508.ref024","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jacc.2012.03.075","article-title":"Health-related quality of life after transcatheter or surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results from the PARTNER (Placement of AoRTic TraNscathetER Valve) Trial (Cohort A).","volume":"60","author":"MR Reynolds","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"pone.0287508.ref025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ahj.2017.08.006","article-title":"Durability of quality of life benefits of transcatheter aortic valve replacement: Long-term results from the CoreValve US extreme risk trial","volume":"194","author":"SJ Baron","year":"2017","journal-title":"Am Heart J"},{"key":"pone.0287508.ref026","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1016\/j.jcin.2016.09.050","article-title":"Quality of Life After Transcatheter Aortic Valve Replacement.","volume":"9","author":"R Lange","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"pone.0287508.ref027","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1161\/CIRCULATIONAHA.111.040022","article-title":"Health-related quality of life after transcatheter aortic valve replacement in inoperable patients with severe aortic stenosis","volume":"124","author":"MR Reynolds","year":"2011","journal-title":"Circulation"},{"key":"pone.0287508.ref028","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/1089253208323411","article-title":"Health-related quality of life after cardiac surgery","volume":"12","author":"CG Koch","year":"2008","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"pone.0287508.ref029","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.ejcts.2009.01.043","article-title":"Therapeutic decisions for patients with symptomatic severe aortic stenosis: room for improvement?","volume":"35","author":"MWA van Geldorp","year":"2009","journal-title":"Eur J Cardio-thoracic Surg"},{"key":"pone.0287508.ref030","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1093\/eurheartj\/ehi471","article-title":"Decision-making in elderly patients with severe aortic stenosis: why are so many denied surgery?","volume":"26","author":"B Iung","year":"2005","journal-title":"Eur Hear J"},{"key":"pone.0287508.ref031","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/hrt.82.2.143","article-title":"To operate or not on elderly patients with aortic stenosis: the decision and its consequences","volume":"82","author":"BJ Bouma","year":"1999","journal-title":"Heart"},{"key":"pone.0287508.ref032","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.jacc.2007.08.011","article-title":"Unoperated Patients With Severe Aortic Stenosis","volume":"50","author":"DS Bach","year":"2007","journal-title":"J Am Coll Cardiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0287508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T13:22:34Z","timestamp":1702646554000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0287508"}},"subtitle":[],"editor":[{"given":"Alessandro","family":"Leone","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0287508","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,21]]}}}