{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:40:23Z","timestamp":1792852823424,"version":"4.5.0"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI140444"],"award-info":[{"award-number":["AI140444"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI146907"],"award-info":[{"award-number":["AI146907"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI087946"],"award-info":[{"award-number":["AI087946"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI132818"],"award-info":[{"award-number":["AI132818"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Flagella-driven motility is essential for\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    to colonize the human stomach, where it causes a variety of diseases, including chronic gastritis, peptic ulcer disease, and gastric cancer.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    has evolved a high-torque-generating flagellar motor that possesses several accessories not found in the archetypical\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    motor. FlgV was one of the first flagellar accessory proteins identified in\n                    <jats:italic>Campylobacter jejuni<\/jats:italic>\n                    , but its structure and function remain poorly understood. Here, we confirm that deletion of\n                    <jats:italic>flgV<\/jats:italic>\n                    in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    B128 and a highly motile variant of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    G27 (G27M) results in reduced motility in soft agar medium. Comparative analyses of\n                    <jats:italic>in-situ<\/jats:italic>\n                    flagellar motor structures of wild-type, \u0394\n                    <jats:italic>flgV<\/jats:italic>\n                    , and a strain expressing FlgV-YFP showed that FlgV forms a ring-like structure closely associated with the junction of two highly conserved flagellar components: the MS and C rings. The results of our studies suggest that the FlgV ring has adapted specifically in Campylobacterota to support the assembly and efficient function of the high-torque-generating motors.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0287514","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T13:34:43Z","timestamp":1700228083000},"page":"e0287514","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["FlgV forms a flagellar motor ring that is required for optimal motility of Helicobacter pylori"],"prefix":"10.1371","volume":"18","author":[{"given":"Jack M.","family":"Botting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2010-212X","authenticated-orcid":true,"given":"Shoichi","family":"Tachiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine H.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2415-412X","authenticated-orcid":true,"given":"Vincent J.","family":"Starai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1101-8030","authenticated-orcid":true,"given":"Timothy 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