{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:04:09Z","timestamp":1775765049383,"version":"3.50.1"},"reference-count":107,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008895","name":"Tertiary Education Trust Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The environmental prevalence of widely prescribed human pharmaceuticals that target key evolutionary conserved biomolecules present across phyla is concerning. Antidepressants, one of the most widely consumed pharmaceuticals globally, have been developed to target biomolecules modulating monoaminergic neurotransmission, thus interfering with the endogenous regulation of multiple key neurophysiological processes. Furthermore, rising prescription and consumption rates of antidepressants caused by the burgeoning incidence of depression is consistent with increasing reports of antidepressant detection in aquatic environments worldwide. Consequently, there are growing concerns that long-term exposure to environmental levels of antidepressants may cause adverse drug target-specific effects on non-target aquatic organisms. While these concerns have resulted in a considerable body of research addressing a range of toxicological endpoints, drug target-specific effects of environmental levels of different classes of antidepressants in non-target aquatic organisms remain to be understood. Interestingly, evidence suggests that molluscs may be more vulnerable to the effects of antidepressants than any other animal phylum, making them invaluable in understanding the effects of antidepressants on wildlife. Here, a protocol for the systematic review of literature to understand drug target-specific effects of environmental levels of different classes of antidepressants on aquatic molluscs is described. The study will provide critical insight needed to understand and characterize effects of antidepressants relevant to regulatory risk assessment decision-making, and\/or direct future research efforts.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The systematic review will be conducted in line with the guidelines by the Collaboration for Environmental Evidence (CEE). A literature search on Scopus, Web of Science, PubMed, as well as grey literature databases, will be carried out. Using predefined criteria, study selection, critical appraisal and data extraction will be done by multiple reviewers with a web-based evidence synthesis platform. A narrative synthesis of outcomes of selected studies will be presented. The protocol has been registered in the Open Science Framework (OSF) registry with the registration DOI: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.17605\/OSF.IO\/P4H8W\" xlink:type=\"simple\">10.17605\/OSF.IO\/P4H8W<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0287582","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T17:30:30Z","timestamp":1687887030000},"page":"e0287582","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Understanding target-specific effects of antidepressant drug pollution on molluscs: A systematic review protocol"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-2106","authenticated-orcid":true,"given":"Maurice E.","family":"Imiuwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Baynes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-364X","authenticated-orcid":true,"given":"Edwin J.","family":"Routledge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"issue":"September","key":"pone.0287582.ref001","first-page":"1","article-title":"Comparative Neurobiology of Biogenic Amines in Animal Models in Deuterostomes.","volume":"8","author":"E D\u2019Aniello","year":"2020","journal-title":"Front Ecol Evol"},{"issue":"2","key":"pone.0287582.ref002","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10158-006-0041-z","article-title":"Eleven new putative aminergic G-protein coupled receptors from Amphioxus (Branchiostoma floridae): Identification, sequence analysis and phylogenetic relationship.","volume":"7","author":"C Burman","year":"2007","journal-title":"Invertebr Neurosci"},{"issue":"19","key":"pone.0287582.ref003","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.184838","article-title":"Invertebrate serotonin receptors: A molecular perspective on classification and pharmacology","volume":"221","author":"AJ Tierney","year":"2018","journal-title":"J Exp Biol"},{"issue":"15","key":"pone.0287582.ref004","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1021\/es8005173","article-title":"Evolutionary conservation of human drug targets in organisms used for environmental risk assessments","volume":"42","author":"L Gunnarsson","year":"2008","journal-title":"Environ Sci Technol"},{"issue":"3","key":"pone.0287582.ref005","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1021\/es404568a","article-title":"In silico analysis of the conservation of human toxicity and endocrine disruption targets in aquatic species","volume":"48","author":"FM McRobb","year":"2014","journal-title":"Environ Sci Technol"},{"issue":"1","key":"pone.0287582.ref006","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrn1008","article-title":"Plasma membrane monoamine transporters: Structure, regulation and function.","volume":"4","author":"GE Torres","year":"2003","journal-title":"Nat Rev Neurosci."},{"issue":"February","key":"pone.0287582.ref007","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","article-title":"The expanded biology of serotonin","volume":"60","author":"M Berger","year":"2009","journal-title":"Annu Rev Med"},{"key":"pone.0287582.ref008","first-page":"1","article-title":"Mechanisms underlying dual effects of serotonin during development of Helisoma trivolvis (Mollusca).","volume":"14","author":"K Glebov","year":"2014"},{"issue":"17","key":"pone.0287582.ref009","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1097\/WNR.0b013e328315a637","article-title":"Monoamine neurons in the human brain stem: Anatomy, magnetic resonance imaging findings, and clinical implications","volume":"19","author":"M Sasaki","year":"2008","journal-title":"Neuroreport"},{"issue":"4","key":"pone.0287582.ref010","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/hipo.20940","article-title":"5-HT1A and 5-HT7 receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission.","volume":"22","author":"L Costa","year":"2012","journal-title":"Hippocampus."},{"issue":"13\u201314","key":"pone.0287582.ref011","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.addr.2008.06.002","article-title":"Monoamine oxidase inactivation: From pathophysiology to therapeutics","volume":"60","author":"M Bortolato","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"pone.0287582.ref012","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jpba.2014.11.040","article-title":"Pharmaceuticals in the environment: Biodegradation and effects on natural microbial communities. A review","volume":"106","author":"A Barra Caracciolo","year":"2015","journal-title":"J Pharm Biomed Anal"},{"issue":"1","key":"pone.0287582.ref013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/a0038550","article-title":"A brief history of the development of antidepressant drugs: From monoamines to glutamate","volume":"23","author":"TM Hillhouse","year":"2015","journal-title":"Exp Clin Psychopharmacol"},{"issue":"6","key":"pone.0287582.ref014","first-page":"205","article-title":"Selecting a Selective Serotonin Reuptake Inhibitor: Clinically Important Distinguishing Features.","volume":"2","author":"PA Marken","year":"2000","journal-title":"Prim Care Companion J Clin Psychiatry."},{"issue":"7","key":"pone.0287582.ref015","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.mppsy.2007.04.007","article-title":"Anxiolytics.","volume":"6","author":"L Sinclair","year":"2007","journal-title":"Psychiatry"},{"issue":"3","key":"pone.0287582.ref016","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/YIC.0b013e3283311acd","article-title":"The pharmacological properties of antidepressants.","volume":"25","author":"G Racagni","year":"2010","journal-title":"Int Clin Psychopharmacol"},{"key":"pone.0287582.ref017","first-page":"1","article-title":"Antidepressant compounds: A critical review.","author":"SW Tang","year":"2010","journal-title":"In: Depression: From Psychopathology to Pharmacotherapy."},{"key":"pone.0287582.ref018","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143722","article-title":"Antidepressant drugs as emerging contaminants: Occurrence in urban and non-urban waters and analytical methods for their detection","volume":"757","author":"C Castillo-Zacar\u00edas","year":"2021","journal-title":"Sci Total Environ"},{"key":"pone.0287582.ref019","first-page":"325","article-title":"Other Antidepressants.","author":"TE Schwasinger-Schmidt","year":"2018","journal-title":"In: Handbook of Experimental Pharmacology"},{"issue":"35","key":"pone.0287582.ref020","first-page":"1","article-title":"National Prescription Patterns of Antidepressants in the Treatment of Adults With Major Depression in the US Between 1996 and 2015: A Population Representative Survey Based Analysis.","volume":"11","author":"Y Luo","year":"2020","journal-title":"Front Psychiatry."},{"issue":"3\u20134","key":"pone.0287582.ref021","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2991\/j.jegh.2018.06.101","article-title":"Pattern of antidepressant utilization and cost in Iran from 2006 to 2013 in comparison with other countries.","volume":"8","author":"F Soleymani","year":"2018","journal-title":"J Epidemiol Glob Health."},{"issue":"1","key":"pone.0287582.ref022","first-page":"1","article-title":"Aerobic exercise prevents depression via alleviating hippocampus injury in chronic stressed depression rats","volume":"11","author":"J Kang","year":"2021","journal-title":"Brain Sci"},{"key":"pone.0287582.ref023","volume-title":"Global burden of mental disorders and the need for a comprehensive, coordinated response from health and social sectors at the country level.","author":"WHO","year":"2011"},{"issue":"3","key":"pone.0287582.ref024","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/etc.2112","article-title":"Persistence of the tricyclic antidepressant drugs amitriptyline and nortriptyline in agriculture soils","volume":"32","author":"H Li","year":"2013","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"pone.0287582.ref025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/j.1875-9114.1997.tb03674.x","article-title":"Mirtazapine: An Antidepressant with Noradrenergic and Specific Serotonergic Effects.","volume":"17","author":"GL Stimmel","year":"1997","journal-title":"Pharmacother J Hum Pharmacol Drug Ther."},{"issue":"3","key":"pone.0287582.ref026","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1515\/dmdi-2013-0053","article-title":"Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers","volume":"29","author":"P Magalh\u00e3es","year":"2014","journal-title":"Drug Metabol Drug Interact"},{"issue":"15","key":"pone.0287582.ref027","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.2165\/00003088-200241150-00002","article-title":"Clinical Pharmacokinetics of Sertraline.","volume":"41","author":"CL Devane","year":"2002","journal-title":"Clin Pharmacokinet."},{"issue":"1","key":"pone.0287582.ref028","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1021\/cn400186j","article-title":"Classics in chemical neuroscience: Fluoxetine (Prozac).","volume":"5","author":"CJ Wenthur","year":"2014","journal-title":"ACS Chem Neurosci."},{"issue":"11","key":"pone.0287582.ref029","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/FPC.0b013e328346063f","article-title":"PharmGKB summary: Citalopram pharmacokinetics pathway","volume":"21","author":"K Sangkuhl","year":"2011","journal-title":"Pharmacogenet Genomics"},{"issue":"17","key":"pone.0287582.ref030","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.1016\/j.watres.2012.07.042","article-title":"Distribution of antidepressant residues in wastewater and biosolids following different treatment processes by municipal wastewater treatment plants in Canada","volume":"46","author":"A Lajeunesse","year":"2012","journal-title":"Water Res"},{"issue":"1","key":"pone.0287582.ref031","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/etc.27","article-title":"Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed","volume":"29","author":"CD Metcalfe","year":"2010","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"pone.0287582.ref032","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ecoenv.2014.02.020","article-title":"Occurrence of antidepressant residues in the sewage-impacted Vistula and Utrata rivers and in tap water in Warsaw (Poland).","volume":"104","author":"J Giebu\u0142towicz","year":"2014","journal-title":"Ecotoxicol Environ Saf"},{"issue":"5","key":"pone.0287582.ref033","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1021\/ac702154e","article-title":"Trace analysis of antidepressant pharmaceuticals and their select degradates in aquatic matrixes by LC\/ESI\/MS\/MS","volume":"80","author":"MM Schultz","year":"2008","journal-title":"Anal Chem"},{"issue":"7","key":"pone.0287582.ref034","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1039\/C8EM00077H","article-title":"Occurrence and source analysis of selected antidepressants and their metabolites in municipal wastewater and receiving surface water.","volume":"20","author":"Ma L dan","year":"2018","journal-title":"Environ Sci Process Impacts"},{"issue":"2","key":"pone.0287582.ref035","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1897\/05-187R.1","article-title":"Presence and distribution of wastewater-derived pharmaceuticals in soil irrigated with reclaimed water","volume":"25","author":"CA Kinney","year":"2006","journal-title":"Environ Toxicol Chem"},{"key":"pone.0287582.ref036","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.watres.2017.08.018","article-title":"Bioaccumulation of psychoactive pharmaceuticals in fish in an effluent dominated stream","volume":"124","author":"K Grabicova","year":"2017","journal-title":"Water Res"},{"key":"pone.0287582.ref037","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ecoenv.2017.12.049","article-title":"The fate and risk assessment of psychiatric pharmaceuticals from psychiatric hospital effluent","volume":"150","author":"J Xiang","year":"2018","journal-title":"Ecotoxicol Environ Saf [Internet]."},{"issue":"6","key":"pone.0287582.ref038","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1021\/es9022706","article-title":"Antidepressant pharmaceuticals in two U.S. effluent-impacted streams: Occurrence and fate in water and sediment and selective uptake in fish neural tissue","volume":"44","author":"MM Schultz","year":"2010","journal-title":"Environ Sci Technol"},{"issue":"1","key":"pone.0287582.ref039","first-page":"1","article-title":"A diverse suite of pharmaceuticals contaminates stream and riparian food webs.","volume":"9","author":"EK Richmond","year":"2018","journal-title":"Nat Commun [Internet]."},{"issue":"7\u20138","key":"pone.0287582.ref040","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1023\/A:1009935116877","article-title":"Drug levels: Therapeutic and toxic serum\/plasma concentrations of common drugs.","volume":"15","author":"R Regenthal","year":"1999","journal-title":"J Clin Monit Comput"},{"key":"pone.0287582.ref041","first-page":"140","article-title":"The mode of action (MOA) approach reveals interactive effects of environmental pharmaceuticals on Mytilus galloprovincialis.","author":"S Franzellitti","year":"2013","journal-title":"Aquat Toxicol"},{"key":"pone.0287582.ref042","first-page":"631","article-title":"Effects of waterborne antidepressants on non-target animals living in the aquatic environment: A review","author":"P Sehonova","year":"2018","journal-title":"Sci Total Environ"},{"issue":"1","key":"pone.0287582.ref043","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/wej.12448","article-title":"The effects of environmental antidepressants on macroinvertebrates: a mini review.","volume":"34","author":"A Shaliutina-Kole\u0161ov\u00e1","year":"2020","journal-title":"Water Environ J"},{"issue":"24","key":"pone.0287582.ref044","doi-asserted-by":"crossref","first-page":"16299","DOI":"10.1021\/acs.est.1c04724","article-title":"The potential for adverse effects in fish exposed to antidepressants in the aquatic environment","volume":"55","author":"SL Gould","year":"2021","journal-title":"Environ Sci Technol"},{"key":"pone.0287582.ref045","first-page":"215","article-title":"Leydig Cell Androgen Synthesis.","author":"L Li","year":"2018","journal-title":"In: Encyclopedia of Reproduction [Internet]."},{"issue":"6349","key":"pone.0287582.ref046","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/354159a0","article-title":"Deletion of steroid 5\u03b1-reductase 2 gene in male pseudohermaphroditism","volume":"354","author":"S Andersson","year":"1991","journal-title":"Nature"},{"issue":"April","key":"pone.0287582.ref047","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jsbmb.2017.07.024","article-title":"Role of 5\u03b1-dihydrotestosterone in testicular development of gilthead seabream following finasteride administration","volume":"174","author":"M Garc\u00eda-Garc\u00eda","year":"2017","journal-title":"J Steroid Biochem Mol Biol [Internet]."},{"issue":"1","key":"pone.0287582.ref048","first-page":"1","article-title":"Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled \u201cbanana-shaped\u201d shell.","volume":"9","author":"A Baynes","year":"2019","journal-title":"Sci Rep [Internet]."},{"issue":"7","key":"pone.0287582.ref049","doi-asserted-by":"crossref","first-page":"e0159852","DOI":"10.1371\/journal.pone.0159852","article-title":"Steroid Androgen Exposure during Development Has No Effect on Reproductive Physiology of Biomphalaria glabrata","volume":"11","author":"S Kaur","year":"2016","journal-title":"PLoS One [Internet]."},{"issue":"4","key":"pone.0287582.ref050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0121259","article-title":"The nuclear receptors of Biomphalaria glabrata and Lottia gigantea:Implications for developing new model organisms.","volume":"10","author":"S Kaur","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"pone.0287582.ref051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-15-369","article-title":"The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group","volume":"15","author":"S Vogeler","year":"2014","journal-title":"BMC Genomics"},{"issue":"July","key":"pone.0287582.ref052","doi-asserted-by":"crossref","first-page":"110526","DOI":"10.1016\/j.mce.2019.110526","article-title":"Steroid receptors and vertebrate evolution","volume":"496","author":"ME Baker","year":"2019","journal-title":"Mol Cell Endocrinol"},{"key":"pone.0287582.ref053","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.dci.2018.03.009","article-title":"D1 dopamine receptor is involved in shell formation in larvae of Pacific oyster Crassostrea gigas","volume":"84","author":"Z Liu","year":"2018","journal-title":"Dev Comp Immunol [Internet]."},{"key":"pone.0287582.ref054","doi-asserted-by":"crossref","first-page":"139469","DOI":"10.1016\/j.scitotenv.2020.139469","article-title":"Ocean acidification inhibits initial shell formation of oyster larvae by suppressing the biosynthesis of serotonin and dopamine","volume":"735","author":"Z Liu","year":"2020","journal-title":"Sci Total Environ"},{"issue":"1","key":"pone.0287582.ref055","first-page":"171","article-title":"Seasonal Variations of Catecholamine Levels in the TIssues of the Japanese Oyster, Crassostrea gigas","volume":"93","author":"M Osada","year":"1989","journal-title":"Comp Biochem Physiol"},{"issue":"2","key":"pone.0287582.ref056","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/07924259.1994.9672381","article-title":"Role of monoamines in the reproductive process of argopecten purpuratus","volume":"25","author":"G Mart\u00ednez","year":"1994","journal-title":"Invertebr Reprod Dev"},{"issue":"3","key":"pone.0287582.ref057","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.cbpa.2009.07.021","article-title":"Monoamine fluctuations during the reproductive cycle of the Pacific lion\u2019s paw scallop Nodipecten subnodosus.","volume":"154","author":"JA L\u00f3pez-S\u00e1nchez","year":"2009","journal-title":"Comp Biochem Physiol\u2014A Mol Integr Physiol"},{"issue":"2","key":"pone.0287582.ref058","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1095-6433(02)00091-0","article-title":"Monoamines in the albumen gland, plasma, and central nervous system of the snail Biomphalaria glabrata during egg-laying.","volume":"132","author":"JP Boyle","year":"2002","journal-title":"Comp Biochem Physiol\u2014A Mol Integr Physiol"},{"issue":"14","key":"pone.0287582.ref059","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1242\/jeb.01052","article-title":"Dopamine stimulates snail albumen gland glycoprotein secretion through the activation of a D1-like receptor.","volume":"207","author":"ST Mukai","year":"2004","journal-title":"J Exp Biol"},{"key":"pone.0287582.ref060","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1201\/b22125","volume-title":"Reproduction and Development in Mollusca [Internet]. Reproduction and Development in Mollusca.","author":"TJ Pandian","year":"2018"},{"issue":"3","key":"pone.0287582.ref061","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1897\/IEAM_2008-003.1","article-title":"An assessment of endocrine disruption in Mollusks and the potential for developing internationally standardized mollusk life cycle test guidelines","volume":"4","author":"P. Matthiessen","year":"2008","journal-title":"Integr Environ Assess Manag"},{"issue":"1\u20132","key":"pone.0287582.ref062","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0304-3940(90)90725-O","article-title":"Indications for a hormonal function of dopamine in the central nervous system of the snail Lymnaea stagnalis","volume":"108","author":"TR Werkman","year":"1990","journal-title":"Neurosci Lett"},{"issue":"2","key":"pone.0287582.ref063","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2307\/3278462","article-title":"5-Hydroxytryptamine and dopamine in Biomphalaria glabrata","volume":"60","author":"PK Chiang","year":"1974","journal-title":"J Parasitol [Internet]."},{"issue":"14","key":"pone.0287582.ref064","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1002\/cne.23095","article-title":"Localization of serotonin in the nervous system of Biomphalaria glabrata, an intermediate host for schistosomiasis","volume":"520","author":"N Delgado","year":"2012","journal-title":"J Comp Neurol"},{"issue":"1","key":"pone.0287582.ref065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00229981","article-title":"Localization of dopamine and its relation to the growth hormone producing cells in the central nervous system of the snail Lymnaea stagnalis","volume":"85","author":"TR Werkman","year":"1991","journal-title":"Exp Brain Res"},{"issue":"3","key":"pone.0287582.ref066","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1677\/joe.1.06964","article-title":"The neuroendocrine system of invertebrates: A developmental and evolutionary perspective","volume":"190","author":"V. Hartenstein","year":"2006","journal-title":"J Endocrinol"},{"issue":"1\u20132","key":"pone.0287582.ref067","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0161-813X(03)00096-2","article-title":"Metabolism of Monoamines in Invertebrates: The Relative Importance of Monoamine Oxidase in Different Phyla","volume":"25","author":"BD Sloley","year":"2004","journal-title":"Neurotoxicology"},{"issue":"2","key":"pone.0287582.ref068","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ygcen.2010.03.008","article-title":"Characterization of a novel octopamine receptor expressed in the surf clam Spisula solidissima","volume":"167","author":"V Blais","year":"2010","journal-title":"Gen Comp Endocrinol [Internet]."},{"key":"pone.0287582.ref069","doi-asserted-by":"crossref","first-page":"103512","DOI":"10.1016\/j.dci.2019.103512","article-title":"Identification of a dopamine receptor in Sinonovacula constricta and its antioxidant responses","volume":"103","author":"D Niu","year":"2020","journal-title":"Dev Comp Immunol [Internet]."},{"issue":"1","key":"pone.0287582.ref070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1073\/pnas.90.1.11","article-title":"Serotonin receptor cDNA cloned from Lymnaea stagnalis","volume":"90","author":"KS Sugamori","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"19","key":"pone.0287582.ref071","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1016\/j.cub.2018.07.061","article-title":"A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus","volume":"28","author":"E Edsinger","year":"2018","journal-title":"Curr Biol"},{"issue":"24","key":"pone.0287582.ref072","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1242\/jeb.02607","article-title":"Ancestry of neuronal monoamine transporters in the Metazoa","volume":"209","author":"S Caveney","year":"2006","journal-title":"J Exp Biol"},{"key":"pone.0287582.ref073","first-page":"132","article-title":"Effects of perinatal exposure to waterborne fluoxetine on memory processing in the cuttlefish Sepia officinalis","author":"C Di Poi","year":"2013","journal-title":"Aquat Toxicol [Internet]."},{"key":"pone.0287582.ref074","first-page":"106","article-title":"Low environmental levels of fluoxetine induce spawning and changes in endogenous estradiol levels in the zebra mussel Dreissena polymorpha","author":"R Lazzara","year":"2012","journal-title":"Aquat Toxicol [Internet]."},{"issue":"2","key":"pone.0287582.ref075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/10236244.2012.690579","article-title":"Antidepressants (venlafaxine and citalopram) cause foot detachment from the substrate in freshwater snails at environmentally relevant concentrations.","volume":"45","author":"PP Fong","year":"2012","journal-title":"Mar Freshw Behav Physiol"},{"key":"pone.0287582.ref076","unstructured":"OECD. DETAILED REVIEW PAPER (DRP) ON MOLLUSCS LIFE-CYCLE TOXICITY TESTING. 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Guidelines and Standards for Evidence Synthesis in Environmental Management [Internet]. Vol. Version 5. 2022. Available from: https:\/\/environmentalevidence.org\/information-for-authors\/."},{"key":"pone.0287582.ref082","article-title":"ROSES for systematic review protocols.","author":"N Haddaway","year":"2017","journal-title":"Version 1.0 [Internet]."},{"issue":"May","key":"pone.0287582.ref083","doi-asserted-by":"crossref","first-page":"105926","DOI":"10.1016\/j.envint.2020.105926","article-title":"Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER).","volume":"143","author":"P Whaley","year":"2020","journal-title":"Environ Int [Internet]."},{"issue":"1","key":"pone.0287582.ref084","doi-asserted-by":"crossref","first-page":"e00007","DOI":"10.1002\/ebm2.7","article-title":"A protocol format for the preparation, registration and publication of systematic reviews of animal intervention studies.","volume":"2","author":"RBM de Vries","year":"2015","journal-title":"Evidence-based Preclin Med"},{"issue":"1","key":"pone.0287582.ref085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13750-017-0099-6","article-title":"Systematic searching for environmental evidence using multiple tools and sources.","volume":"6","author":"B Livoreil","year":"2017","journal-title":"Environ Evid"},{"issue":"1","key":"pone.0287582.ref086","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12940-016-0156-6","article-title":"A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals.","volume":"15","author":"LN Vandenberg","year":"2016","journal-title":"Environ Heal"},{"key":"pone.0287582.ref087","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.biocon.2015.08.018","article-title":"Shades of grey: Two forms of grey literature important for reviews in conservation","volume":"191","author":"NR Haddaway","year":"2015","journal-title":"Biol Conserv [Internet]."},{"issue":"1","key":"pone.0287582.ref088","first-page":"1","article-title":"Searching and synthesising \u201cgrey literature\u201d and \u201cgrey information\u201d in public health: Critical reflections on three case studies.","volume":"5","author":"J Adams","year":"2016","journal-title":"Syst Rev [Internet]."},{"key":"pone.0287582.ref089","first-page":"2","volume-title":"EPPI-Reviewer 4: software for research synthesis. EPPI-Centre Software [Internet].","author":"J Thomas","year":"2010"},{"issue":"10","key":"pone.0287582.ref090","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1007\/s00204-017-2043-5","article-title":"Toxicological interactions of pesticide mixtures: an update","volume":"91","author":"AF Hern\u00e1ndez","year":"2017","journal-title":"Arch Toxicol"},{"issue":"2","key":"pone.0287582.ref091","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00359-011-0695-9","article-title":"Neural control of olfaction and tentacle movements by serotonin and dopamine in terrestrial snail","volume":"198","author":"M Roshchin","year":"2012","journal-title":"J Comp Physiol A Neuroethol Sensory, Neural, Behav Physiol."},{"issue":"1","key":"pone.0287582.ref092","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1017\/S0006323196004975","article-title":"Serotonergic modulation of behaviour: A phylogenetic overview","volume":"72","author":"WA Weiger","year":"1997","journal-title":"Biol Rev"},{"issue":"1654","key":"pone.0287582.ref093","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1098\/rspb.2008.0683","article-title":"Different functions for homologous serotonergic interneurons and serotonin in species-specific rhythmic behaviours","volume":"276","author":"JM Newcomb","year":"2009","journal-title":"Proc R Soc B Biol Sci"},{"issue":"9","key":"pone.0287582.ref094","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1242\/jeb.204.9.1625","article-title":"Effects of serotonin, dopamine and ergometrine on locomotion in the pulmonate mollusc Helix lucorum","volume":"204","author":"GA Pavlova","year":"2001","journal-title":"J Exp Biol"},{"issue":"1\u20132","key":"pone.0287582.ref095","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.resp.2006.02.009","article-title":"Modulation of aerial respiratory behaviour in a pond snail","volume":"154","author":"K Lukowiak","year":"2006","journal-title":"Respir Physiol Neurobiol"},{"issue":"3","key":"pone.0287582.ref096","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0300-9629(89)90024-8","article-title":"Morphology and electrophysiology of neurons innervating the ciliated locomotor epithelium in Lymnaea stagnalis (L.).","volume":"93","author":"NI Syed","year":"1989","journal-title":"Comp Biochem Physiol\u2014Part A Physiol"},{"issue":"7","key":"pone.0287582.ref097","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1242\/jeb.205.7.877","article-title":"Comparative neuroethology of feeding control in molluscs","volume":"205","author":"CJH Elliott","year":"2002","journal-title":"J Exp Biol"},{"issue":"SUPPL.","key":"pone.0287582.ref098","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1556\/ABiol.59.2008.Suppl.6","article-title":"Humoral serotonin and dopamine modulate the feeding in the snail, Helix pomatia","volume":"59","author":"L Hern\u00e1di","year":"2008","journal-title":"Acta Biol Hung"},{"issue":"1","key":"pone.0287582.ref099","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cbpc.2008.07.004","article-title":"Role of aminergic (serotonin and dopamine) systems in the embryogenesis and different embryonic behaviors of the pond snail, Lymnaea stagnalis.","volume":"149","author":"A Filla","year":"2009","journal-title":"Comp Biochem Physiol\u2014C Toxicol Pharmacol [Internet]."},{"key":"pone.0287582.ref100","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.dci.2017.12.029","article-title":"A serotonin receptor (Cg5-HTR-1) mediating immune response in oyster Crassostrea gigas.","volume":"82","author":"Y Jia","year":"2018","journal-title":"Dev Comp Immunol [Internet]."},{"issue":"1","key":"pone.0287582.ref101","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-87435-0","article-title":"Dimeric mimetic of BDNF loop 4 promotes survival of serum-deprived cell through TrkB-dependent apoptosis suppression","volume":"11","author":"LF Zainullina","year":"2021","journal-title":"Sci Rep"},{"issue":"22","key":"pone.0287582.ref102","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214445","article-title":"BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions.","volume":"23","author":"S Cubillos","year":"2022","journal-title":"Int J Mol Sci."},{"key":"pone.0287582.ref103","first-page":"92","article-title":"How credible are the study results? 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