{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:33:19Z","timestamp":1772217199406,"version":"3.50.1"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1126780"],"award-info":[{"award-number":["OPP1126780"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Maternal hypertension may be an underrecognized but important risk factor for perinatal death in low resource settings. We investigated the association of maternal hypertension and perinatal mortality in rural Bangladesh. This nested, matched case-control study used data from a 2019 cross-sectional survey and demographic surveillance database in Baliakandi, Bangladesh. We randomly matched each pregnancy ending in perinatal death with five pregnancies in which the neonate survived beyond seven days based on maternal age, education, and wealth quintile. We estimated associations of antenatal care-seeking and self-reported hypertension with perinatal mortality using conditional logistic regression and used median and interquartile ranges to assess the mediation of antenatal care by timing or frequency. Among 191 cases and 934 matched controls, hypertension prevalence was 14.1% among cases and 7.7% among controls. Compared with no diagnosis, the probability of perinatal death was significantly higher among women with a pre-gestational hypertension diagnosis (OR 2.90, 95% CI 1.29, 6.57), but not among women with diagnosis during pregnancy (OR 1.68, 95% CI 0.98, 2.98). We found no association between the number of antenatal care contacts and perinatal death (p = 0.66). Among women with pre-gestational hypertension who experienced a perinatal death, 78% had their first antenatal contact in the sixth or seventh month of gestation. Hypertension was more common among rural women who experience a perinatal death. Greater effort to prevent hypertension prior to conception and provide early maternity care to women with hypertension could improve perinatal outcomes in rural Bangladesh.<\/jats:p>","DOI":"10.1371\/journal.pone.0287622","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T13:29:46Z","timestamp":1721654986000},"page":"e0287622","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations of hypertension and antenatal care-seeking with perinatal mortality: A nested case-control study in rural Bangladesh"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6474-5149","authenticated-orcid":true,"given":"Allyson P.","family":"Bear","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy L.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Han","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atique Iqbal","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanwarul","family":"Bari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shams","family":"El Arifeen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8648-9403","authenticated-orcid":true,"given":"Emily S.","family":"Gurley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"pone.0287622.ref001","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bpobgyn.2011.01.006","article-title":"Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy.","volume":"25","author":"JA Hutcheon","year":"2011","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"pone.0287622.ref002","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.preghy.2014.01.003","article-title":"Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy.","volume":"4","author":"LA Magee","year":"2014","journal-title":"Pregnancy Hypertension: An International Journal of Women\u2019s Cardiovascular Health."},{"key":"pone.0287622.ref003","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0140-6736(15)00837-5","article-title":"Stillbirths: rates, risk factors, and acceleration towards 2030","volume":"387","author":"JE Lawn","year":"2016","journal-title":"Lancet"},{"key":"pone.0287622.ref004","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(14)60496-7","article-title":"Every Newborn: progress, priorities, and potential beyond survival","volume":"384","author":"JE Lawn","year":"2014","journal-title":"The Lancet"},{"key":"pone.0287622.ref005","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/1471-0528.12633","article-title":"Maternal complications and perinatal mortality: findings of the World Health Organization Multicountry Survey on Maternal and Newborn Health.","volume":"121","author":"JP Vogel","year":"2014","journal-title":"BJOG"},{"key":"pone.0287622.ref006","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bpobgyn.2016.05.005","article-title":"Preventing deaths due to the hypertensive disorders of pregnancy.","volume":"36","author":"P von Dadelszen","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"pone.0287622.ref007","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/CIRCULATIONAHA.115.018912","article-title":"Global disparities of hypertension prevalence and control","volume":"134","author":"KT Mills","year":"2016","journal-title":"Circulation"},{"key":"pone.0287622.ref008","unstructured":"National Institute of Population Research and Training (NIPORT), Mitra and Associates and II. 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The DHS Wealth Index: Approaches for Rural and Urban Areas. Rockville, Maryland; 2008 Oct. Available: www.measuredhs.com"},{"key":"pone.0287622.ref027","unstructured":"Rutstein SO, Johnson K. The DHS wealth index. DHS Comparative Reports No. 6. Calverton, Maryland; 2004 Aug. Available: http:\/\/www.measuredhs.comorbycontacting"},{"key":"pone.0287622.ref028","unstructured":"National Institute of Population Research and Training (NIPORT), MEASURE Evaluation, and icddr b. Bangladesh Maternal Mortality and Health Care Survey 2010. Dhaka, Bangladesh; 2012. Available: https:\/\/www.measureevaluation.org\/resources\/publications\/tr-12-87"},{"key":"pone.0287622.ref029","unstructured":"MEASURE Evaluation, National Institute of Population Research and Training, International Centre for Diarrhoeal Disease Research, Bangladesh and ME. Bangladesh: Maternal Mortality and Health Care Survey 2016: Preliminary Report. 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