{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:39:47Z","timestamp":1779079187038,"version":"3.51.4"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["TKP2021-NVA-06"],"award-info":[{"award-number":["TKP2021-NVA-06"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Traumatic aorta injury (TAI) is the second most common traumatic cause of death preceded only by head injuries, being responsible for 5% to 30% of all mortalities in high-speed deceleration injuries. Multiple external factors might play a role such as impact speed, impact direction, occupant location, and presence or lack of restraining safety mechanism. Apart from these external factors, also human biological factors can influence its development. Based on the data of scientific literature, age clearly plays a role in suffering TAI, but the role of atherosclerosis\u2013as a disease affecting the structure of the aorta\u2013is unknown. Biomechanical properties of tissue samples of 104 aorta specimens removed during the autopsy from the posterior (Group \u2018A\u2019) and lateral wall (Group \u2018B\u2019) of descending aorta were analyzed. Specimens were examined by a Zwick\/Roell Z5.0 biaxial tester. The Young\u2019s modulus (<jats:italic>E<\/jats:italic> (MPa)) was calculated using a linear regression procedure where the base of the elongation was the parallel length of the sample, the achieved maximal force (<jats:italic>F<\/jats:italic><jats:sub>max<\/jats:sub> (N)), the elongation at the time of <jats:italic>F<\/jats:italic><jats:sub>max<\/jats:sub> (<jats:italic>L<\/jats:italic><jats:sub>max<\/jats:sub> (mm)), the force at the beginning of rupture (<jats:italic>F<\/jats:italic><jats:sub>break<\/jats:sub> (N)), the elongation at the time of <jats:italic>F<\/jats:italic><jats:sub>break<\/jats:sub> (<jats:italic>L<\/jats:italic><jats:sub>break<\/jats:sub> (mm)) were registered. Specimens were categorized based on macroscopic and microscopic appearance. In the posterior (A) samples the difference between <jats:italic>L<\/jats:italic><jats:sub>break<\/jats:sub> (p&lt;0.001) and <jats:italic>L<\/jats:italic><jats:sub>max<\/jats:sub> (p&lt;0.001) was significant between the macroscopic group. <jats:italic>L<\/jats:italic><jats:sub>break<\/jats:sub> (p = 0.009) and <jats:italic>L<\/jats:italic><jats:sub>max<\/jats:sub> (p = 0.003) showed similar pattern in the lateral (B) samples. Comparing the histological groups by the measured parameters (<jats:italic>F<\/jats:italic><jats:sub>max<\/jats:sub>, <jats:italic>L<\/jats:italic><jats:sub>max<\/jats:sub>, <jats:italic>F<\/jats:italic><jats:sub>break<\/jats:sub>, <jats:italic>L<\/jats:italic><jats:sub>break<\/jats:sub>) showed a significant difference in the means (p&lt;0.001, p = 0.003, p&lt;0.001 respectively). The study demonstrated that atherosclerosis decreases the resistance of the aorta. The rupture occurs at lower force (<jats:italic>F<\/jats:italic><jats:sub>max<\/jats:sub> and <jats:italic>F<\/jats:italic><jats:sub>break<\/jats:sub>), and at shorter elongation (<jats:italic>L<\/jats:italic><jats:sub>max<\/jats:sub> and <jats:italic>L<\/jats:italic><jats:sub>break<\/jats:sub>) in case of the presence of atherosclerosis. This effect is most substantial if calcification is present: the resistance of aorta affected by calcification is only two-thirds on average compared to aorta affected by the early phase of atherosclerosis. This phenomenon can be clearly explained by the weakening structure of the tunica intima.<\/jats:p>","DOI":"10.1371\/journal.pone.0287652","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T17:56:36Z","timestamp":1694195796000},"page":"e0287652","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biomechanical study on the effect of atherosclerosis on the vulnerability of thoracic aorta, and it\u2019s role in the development of traumatic aorta injury"],"prefix":"10.1371","volume":"18","author":[{"given":"D\u00e9nes","family":"Pauka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor Soma","family":"Po\u00f3r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-0675","authenticated-orcid":true,"given":"P\u00e9ter","family":"Mar\u00f3ti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2259-1043","authenticated-orcid":true,"given":"Roland","family":"Told","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-3478","authenticated-orcid":true,"given":"D\u00e9nes","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Torn\u00f3czky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s F.","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6153-3260","authenticated-orcid":true,"given":"G\u00e1bor","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"pone.0287652.ref001","article-title":"No Title [Internet]","author":"WHO","journal-title":"Road traffic injuries"},{"issue":"1","key":"pone.0287652.ref002","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejvs.2008.09.024","article-title":"Optimal management of traumatic aortic injury","volume":"37","author":"R Fattori","year":"2009","journal-title":"Eur J Vasc Endovasc Surg Off J Eur Soc Vasc Surg"},{"issue":"1","key":"pone.0287652.ref003","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1055\/s-0041-1724009","article-title":"Thoracic Trauma: Aortic Injuries.","volume":"38","author":"A Monga","year":"2021","journal-title":"Semin Intervent Radiol."},{"issue":"2","key":"pone.0287652.ref004","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1010-7940(02)00720-0","article-title":"Rupture of the aorta following road traffic accidents in the United Kingdom 1992\u20131999. 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