{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:20:29Z","timestamp":1747196429496,"version":"3.40.5"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Public Health Ontario Project Initiation Fund"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nObjectives<\/jats:title>\nTo investigate maternal antibody levels to varicella in infants <12 months of age in Ontario, Canada.<\/jats:p>\n<\/jats:sec>\n\nStudy design<\/jats:title>\nIn this study, we included specimens from infants <12 months of age, born at \u226537 weeks gestational age, who had sera collected at The Hospital for Sick Children (Toronto, Canada) between 2014\u20132016. We tested sera using a glycoprotein-based enzyme-linked immunosorbent assay (gpELISA). We measured varicella susceptibility (antibody concentration <150mIU\/mL) and mean varicella antibody concentration, and assessed the probability of susceptibility and concentration between one and 11 months of age using multivariable logistic regression and Poisson regression.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nWe found that 32% of 196 included specimens represented infants susceptible to varicella at one month of age, increasing to nearly 80% at three months of age. At six months of age, all infants were susceptible to varicella and the predicted mean varicella antibody concentration declined to 62 mIU\/mL (95% confidence interval 40, 84), well below the threshold of protection.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nWe found that varicella maternal antibody levels wane rapidly in infants, leaving most infants susceptible by four months of age. Our findings have implications for the timing of first dose of varicella-containing vaccine, infection control measures, and infant post-exposure prophylaxis recommendations.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0287765","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T18:24:45Z","timestamp":1699640685000},"page":"e0287765","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal varicella antibodies in children aged less than one year: Assessment of antibody decay"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9100-5928","authenticated-orcid":true,"given":"Shelly","family":"Bolotin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel D.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Severini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3245-6956","authenticated-orcid":true,"given":"Callum","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7751-7628","authenticated-orcid":true,"given":"Susan","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha S.","family":"Crowcroft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Deek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-2528","authenticated-orcid":true,"given":"Todd","family":"Hatchette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan B.","family":"Gubbay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Science","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"issue":"Suppl 1","key":"pone.0287765.ref001","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S0163-4453(17)30188-3","article-title":"Is chickenpox so bad, what do we know about immunity to varicella zoster virus, and what does it tell us about the future?","volume":"74","author":"AA Gershon","year":"2017","journal-title":"J Infect"},{"key":"pone.0287765.ref002","unstructured":"Vaccines SWG on V and HZ. Background Paper on Varicella Vaccine."},{"key":"pone.0287765.ref003","unstructured":"Lopez, Adriana, Harrington, Theresa, Marin M. Varicella. 2021. https:\/\/www.cdc.gov\/vaccines\/pubs\/pinkbook\/varicella.html"},{"key":"pone.0287765.ref004","doi-asserted-by":"crossref","first-page":"1900233","DOI":"10.2807\/1560-7917.ES.2019.24.42.1900233","article-title":"Burden of varicella complications in secondary care, England, 2004 to 2017","volume":"24","author":"JL Bernal","year":"2019","journal-title":"Euro Surveill"},{"key":"pone.0287765.ref005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijid.2017.07.009","article-title":"Too young to be vaccinated: hospitalizations caused by varicella among children in the first year of life","volume":"62","author":"E Gowin","year":"2017","journal-title":"International Journal of Infectious Diseases"},{"key":"pone.0287765.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14745\/ccdr.v36i00a10","article-title":"Literature Review on One-Dose and Two-Dose Varicella Vaccination: An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI)(\u2020)","volume":"36","author":"A Campbell","year":"2010","journal-title":"Can Commun Dis Rep"},{"key":"pone.0287765.ref007","doi-asserted-by":"crossref","first-page":"241","DOI":"10.14745\/ccdr.v41i10a04","article-title":"A spot of bother: Why varicella vaccine programs matter","volume":"41","author":"T Harris","year":"2015","journal-title":"Can Commun Dis Rep"},{"key":"pone.0287765.ref008","unstructured":"NACI Statement: Varicella vaccination recommendations. In: CCDR [Internet]. 2010. https:\/\/www.canada.ca\/en\/public-health\/services\/reports-publications\/canada-communicable-disease-report-ccdr\/monthly-issue\/2010-36\/canada-communicable-disease-report-13.html"},{"key":"pone.0287765.ref009","doi-asserted-by":"crossref","first-page":"e0129483","DOI":"10.1371\/journal.pone.0129483","article-title":"Twenty years of medically-attended pediatric varicella and Herpes Zoster in Ontario, Canada: a population-based study","volume":"10","author":"AE Wormsbecker","year":"2015","journal-title":"PLoS One"},{"key":"pone.0287765.ref010","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(06)69561-5","article-title":"Varicella","volume":"368","author":"U Heininger","year":"2006","journal-title":"The Lancet"},{"key":"pone.0287765.ref011","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00431-010-1212-9","article-title":"Hospitalization of newborns and young infants for chickenpox in France","volume":"169","author":"A L\u00e9cuyer","year":"2010","journal-title":"Eur J Pediatr"},{"key":"pone.0287765.ref012","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00006454-199402000-00015","article-title":"Outbreak and control of varicella in a neonatal intensive care unit","volume":"13","author":"CA Friedman","year":"1994","journal-title":"Pediatr Infect Dis J"},{"key":"pone.0287765.ref013","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/infdis\/jit143","article-title":"Waning of maternal antibodies against measles, mumps, rubella, and varicella in communities with contrasting vaccination coverage","volume":"208","author":"S Waaijenborg","year":"2013","journal-title":"J Infect Dis"},{"key":"pone.0287765.ref014","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/j.vaccine.2010.06.004","article-title":"Kinetics of maternal antibodies against rubella and varicella in infants","volume":"29","author":"E Leuridan","year":"2011","journal-title":"Vaccine"},{"key":"pone.0287765.ref015","doi-asserted-by":"crossref","first-page":"79 LP","DOI":"10.1542\/peds.109.1.79","article-title":"Neonatal Antibody Titers Against Varicella-Zoster Virus in Relation to Gestational Age, Birth Weight, and Maternal Titer","volume":"109","author":"WC van der Zwet","year":"2002","journal-title":"Pediatrics"},{"key":"pone.0287765.ref016","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00296-19","article-title":"Calibration and Evaluation of Quantitative Antibody Titers for Varicella-Zoster Virus by Use of the BioPlex 2200","volume":"57","author":"E McLachlan","year":"2019","journal-title":"J Clin Microbiol"},{"key":"pone.0287765.ref017","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1128\/CVI.13.2.214-218.2006","article-title":"Performance of a time-resolved fluorescence immunoassay for measuring varicella-zoster virus immunoglobulin G levels in adults and comparison with commercial enzyme immunoassays and Merck glycoprotein enzyme immunoassay","volume":"13","author":"PA Maple","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"pone.0287765.ref018","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jcv.2011.12.010","article-title":"Comparison of a commercial Varicella Zoster glycoprotein IgG enzyme immunoassay with a reference time resolved fluorescence immunoassay (VZV TRFIA) for measuring VZV IgG in sera from pregnant women, sera sent for confirmatory testing and pre and post vOka","volume":"53","author":"PA Maple","year":"2012","journal-title":"J Clin Virol"},{"key":"pone.0287765.ref019","doi-asserted-by":"crossref","first-page":"e20190630","DOI":"10.1542\/peds.2019-0630","article-title":"Measles Antibody Levels in Young Infants","volume":"144","author":"M Science","year":"2019","journal-title":"Pediatrics"},{"key":"pone.0287765.ref020","unstructured":"CDC. Varicella Vaccination Information for Healthcare Professionals. https:\/\/www.cdc.gov\/vaccines\/vpd\/varicella\/hcp\/index.html"},{"key":"pone.0287765.ref021","unstructured":"Government of Canada. Provincial and territorial routine and catch-up vaccination schedule for infants and children in Canada. 2021. https:\/\/www.canada.ca\/en\/public-health\/services\/provincial-territorial-immunization-information\/provincial-territorial-routine-vaccination-programs-infants-children.html"},{"key":"pone.0287765.ref022","unstructured":"Australian Government. Varicella (chickenpox). 2019. https:\/\/immunisationhandbook.health.gov.au\/vaccine-preventable-diseases\/varicella-chickenpox"},{"key":"pone.0287765.ref023","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1016\/j.vaccine.2006.01.026","article-title":"Seroprevalence of Varicella-Zoster virus IgG antibodies in Swiss children during the first 16 months of age","volume":"24","author":"U Heininger","year":"2006","journal-title":"Vaccine"},{"key":"pone.0287765.ref024","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/CVI.00397-08","article-title":"Prevalence of anti-varicella-zoster virus antibodies in French infants under 15 months of age","volume":"16","author":"D Pinquier","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"pone.0287765.ref025","unstructured":"Varicella (chickenpox) vaccine: Canadian Immunization Guide."},{"key":"pone.0287765.ref026","unstructured":"Public Health England. Guidance for issuing varicella-zoster immunoglobulin (VZIG)."},{"key":"pone.0287765.ref027","unstructured":"Prevention C for DC and. Chickenpox (Varicella). https:\/\/www.cdc.gov\/chickenpox\/hcp\/index.html#:~:text=Recovery from primary varicella infection, in people who are immunocompromised"},{"key":"pone.0287765.ref028","unstructured":"Ontario Ministry of Health and Long-Term Care. Varicella (chickenpox). 2019."},{"key":"pone.0287765.ref029","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1590\/S1135-57272009000500012","article-title":"Epidemiolog\u00eda de la varicela en Espa\u00f1a en los per\u00edodos pre y post vacunaci\u00f3n [Epidemiology of varicella in spain pre-and post-vaccination periods]","volume":"83","author":"I Pe\u00f1a-Rey","year":"2009","journal-title":"Rev Esp Salud Publica"},{"key":"pone.0287765.ref030","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/infdis\/148.2.200","article-title":"Immunologic Evidence of Reinfection with Varicella-Zoster Virus","volume":"148","author":"AM Arvin","year":"1983","journal-title":"J Infect Dis"},{"key":"pone.0287765.ref031","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/j.vaccine.2017.03.054","article-title":"Varicella seroepidemiology in United States air force recruits: A retrospective cohort study comparing immunogenicity of varicella vaccination and natural infection","volume":"35","author":"JR Duncan","year":"2017","journal-title":"Vaccine"},{"key":"pone.0287765.ref032","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/501900","article-title":"Persistence of immunity to varicella-zoster virus after vaccination of healthcare workers","volume":"22","author":"L Saiman","year":"2001","journal-title":"Infect Control Hosp Epidemiol"},{"key":"pone.0287765.ref033","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jcv.2013.01.015","article-title":"Varicella immunity in vaccinated healthcare workers","volume":"57","author":"A Behrman","year":"2013","journal-title":"Journal of Clinical Virology"},{"key":"pone.0287765.ref034","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijid.2020.04.082","article-title":"Varicella seroepidemiology and immunization in a cohort of future healthcare workers in the pre-vaccination era","volume":"96","author":"A Trevisan","year":"2020","journal-title":"International Journal of Infectious Diseases"},{"key":"pone.0287765.ref035","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1186\/s12879-021-06180-x","article-title":"Long -term persistence of antibodies against varicella in fully immunized healthcare workers: an Italian retrospective cohort study","volume":"21","author":"FP Bianchi","year":"2021","journal-title":"BMC Infect Dis"},{"key":"pone.0287765.ref036","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.vaccine.2019.12.067","article-title":"Women who received varicella vaccine versus natural infection have different long-term T cell immunity but similar antibody levels","volume":"38","author":"E Tourtelot","year":"2020","journal-title":"Vaccine"},{"key":"pone.0287765.ref037","first-page":"555","article-title":"Vaccination with measles, mumps and rubella vaccine and varicella vaccine: safety, tolerability, immunogenicity, persistence of antibody and duration of protection against varicella in healthy children","volume":"21","author":"KBKPMT for Varivax","journal-title":"Pediatr Infect Dis J"},{"key":"pone.0287765.ref038","unstructured":"World Health Organization. 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