{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:09:50Z","timestamp":1782450590238,"version":"3.54.5"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The human family of ETS transcription factors numbers 28 genes which control multiple aspects of development, notably the differentiation of blood and immune cells. Otherwise, aberrant expression of ETS genes is reportedly involved in forming leukemia and lymphoma. Here, we comprehensively mapped ETS gene activities in early hematopoiesis, lymphopoiesis and all mature types of lymphocytes using public datasets. We have termed the generated gene expression pattern lymphoid ETS-code. This code enabled identification of deregulated ETS genes in patients with lymphoid malignancies, revealing 12 aberrantly expressed members in Hodgkin lymphoma (HL). For one of these, ETS gene ETV3, expression in stem and progenitor cells in addition to that in developing and mature T-cells was mapped together with downregulation in B-cell differentiation. In contrast, subsets of HL patients aberrantly overexpressed ETV3, indicating oncogenic activity in this B-cell malignancy. Analysis of ETV3-overexpressing HL cell line SUP-HD1 demonstrated genomic duplication of the ETV3 locus at 1q23, GATA3 as mutual activator, and suppressed BMP-signalling as mutual downstream effect. Additional examination of the neighboring ETS genes ETS1 and FLI1 revealed physiological activities in B-cell development and aberrant downregulation in HL patient subsets. SUP-HD1 showed genomic loss on chromosome 11, del(11)(q22q25), targeting both ETS1 and FLI1, underlying their downregulation. Furthermore, in the same cell line we identified PBX1-mediated overexpression of RIOK2 which inhibited ETS1 and activated JAK2 expression. Collectively, we codified normal ETS gene activities in lymphopoiesis and identified oncogenic ETS members in HL.<\/jats:p>","DOI":"10.1371\/journal.pone.0288031","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T17:37:51Z","timestamp":1689010671000},"page":"e0288031","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Establishment of the lymphoid ETS-code reveals deregulated ETS genes in Hodgkin lymphoma"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-8988","authenticated-orcid":true,"given":"Stefan","family":"Nagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pommerenke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"pone.0288031.ref001","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-immunol-032712-100024","article-title":"Transcriptional control of early T and B cell developmental choices","volume":"32","author":"E.V. Rothenberg","year":"2014","journal-title":"Annu. Rev. Immunol"},{"key":"pone.0288031.ref002","doi-asserted-by":"crossref","first-page":"e104983","DOI":"10.15252\/embj.2020104983","article-title":"Interactions between lineage-associated transcription factors govern haematopoietic progenitor states","volume":"39","author":"I. Kucinski","year":"2020","journal-title":"EMBO J"},{"issue":"2","key":"pone.0288031.ref003","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.cell.2018.09.045","article-title":"The human transcription factors","volume":"175","author":"SA Lambert","year":"2018","journal-title":"Cell"},{"issue":"4","key":"pone.0288031.ref004","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.stem.2010.07.016","article-title":"Combinatorial transcriptional control in blood stem\/progenitor cells: genome-wide analysis of ten major transcriptional regulators","volume":"7","author":"NK Wilson","year":"2010","journal-title":"Cell Stem Cell"},{"key":"pone.0288031.ref005","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.3390\/cancers13081961","article-title":"NKL-Code in normal and aberrant hematopoiesis","volume":"13","author":"S. 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Krenacs","year":"1998","journal-title":"Blood"},{"key":"pone.0288031.ref025","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/leu.2012.280","article-title":"Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma","volume":"27","author":"V. Bohle","year":"2013","journal-title":"Leukemia"},{"issue":"4","key":"pone.0288031.ref026","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2174\/092986708783497319","article-title":"Human leukemia and lymphoma cell lines as models and resources","volume":"15","author":"RAF MacLeod","year":"2008","journal-title":"Curr Med Chem"},{"issue":"1","key":"pone.0288031.ref027","doi-asserted-by":"crossref","first-page":"8218","DOI":"10.1038\/s41598-019-44491-x","article-title":"The LL-100 panel: 100 cell lines for blood cancer studies","volume":"9","author":"H Quentmeier","year":"2019","journal-title":"Sci Rep"},{"issue":"12","key":"pone.0288031.ref028","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1182\/blood.V96.12.3681","article-title":"CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features","volume":"96","author":"H Stein","year":"2000","journal-title":"Blood"},{"key":"pone.0288031.ref029","first-page":"72","article-title":"Cytogenetic findings and results of combined immunophenotyping and karyotyping in Hodgkin\u2019s disease","volume":"8","author":"B Schlegelberger","year":"1994","journal-title":"Leukemia"},{"key":"pone.0288031.ref030","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/sj.leu.2401894","article-title":"Karyotypic dissection of Hodgkin\u2019s disease cell lines reveals ectopic subtelomeres and ribosomal DNA at sites of multiple jumping translocations and genomic amplification","volume":"14","author":"RA MacLeod","year":"2000","journal-title":"Leukemia"},{"issue":"8","key":"pone.0288031.ref031","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/gcc.22069","article-title":"Chromothripsis in Hodgkin lymphoma","volume":"52","author":"S Nagel","year":"2013","journal-title":"Genes Chromosomes Cancer"},{"issue":"15","key":"pone.0288031.ref032","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1093\/emboj\/cdf389","article-title":"Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B","volume":"21","author":"S Mathas","year":"2002","journal-title":"EMBO J"},{"issue":"4","key":"pone.0288031.ref033","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1172\/JCI200316624","article-title":"Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling","volume":"111","author":"R K\u00fcppers","year":"2003","journal-title":"J Clin Invest"},{"issue":"2","key":"pone.0288031.ref034","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00428-019-02570-4","article-title":"Systemic, primary cutaneous, and breast implant-associated ALK-negative anaplastic large-cell lymphomas present similar biologic features despite distinct clinical behavior","volume":"475","author":"A Gerbe","year":"2019","journal-title":"Virchows Arch"},{"issue":"17","key":"pone.0288031.ref035","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1158\/0008-5472.CAN-05-0925","article-title":"JunB induced by constitutive CD30-extracellular signal-regulated kinase 1\/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphoma","volume":"65","author":"M Watanabe","year":"2005","journal-title":"Cancer Res"},{"issue":"2","key":"pone.0288031.ref036","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/path.1825","article-title":"BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas","volume":"207","author":"J Kluiver","year":"2005","journal-title":"J Pathol"},{"issue":"1","key":"pone.0288031.ref037","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41590-021-01079-w","article-title":"Identification of RIOK2 as a master regulator of human blood cell development","volume":"23","author":"S Ghosh","year":"2022","journal-title":"Nat Immunol"},{"issue":"4","key":"pone.0288031.ref038","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bcmd.2013.07.010","article-title":"ETS transcription factors in hematopoietic stem cell development","volume":"51","author":"A Ciau-Uitz","year":"2013","journal-title":"Blood Cells Mol Dis"},{"issue":"1","key":"pone.0288031.ref039","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10549-013-2408-2","article-title":"Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes","volume":"138","author":"B Mesquita","year":"2013","journal-title":"Breast Cancer Res Treat"},{"issue":"20","key":"pone.0288031.ref040","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1182\/blood-2015-07-655530","article-title":"ETV3-NCOA2 in in-determinate cell histiocytosis: clonal translocation supports sui generis","volume":"126","author":"RA Brown","year":"2015","journal-title":"Blood"},{"issue":"7","key":"pone.0288031.ref041","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/DAD.0000000000002167","article-title":"An atypical myelomonocytic cell infiltrate: use of next-generation sequencing to diagnose indeterminate cell histiocytosis","volume":"44","author":"ME Belina","year":"2022","journal-title":"Am J Dermatopathol"},{"issue":"2","key":"pone.0288031.ref042","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0092-8674(02)00714-6","article-title":"An induced Ets repressor complex regulates growth arrest during terminal macro-phage differentiation","volume":"109","author":"GW Klappacher","year":"2002","journal-title":"Cell"},{"issue":"1","key":"pone.0288031.ref043","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41590-022-01374-0","article-title":"ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment","volume":"24","author":"J Villar","year":"2023","journal-title":"Nat Immunol"},{"issue":"6242","key":"pone.0288031.ref044","doi-asserted-by":"crossref","first-page":"aaa5838","DOI":"10.1126\/science.aaa5838","article-title":"EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning","volume":"348","author":"E Bier","year":"2015","journal-title":"Science"},{"issue":"9","key":"pone.0288031.ref045","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/leu.2011.95","article-title":"The role of Smad signaling in hematopoiesis and translational hematology","volume":"25","author":"U Blank","year":"2011","journal-title":"Leukemia"},{"issue":"3","key":"pone.0288031.ref046","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2567.2011.03495.x","article-title":"Compartmentalization of bone morphogenetic proteins and their antagonists in lymphoid progenitors and supporting microenvironments and functional implications","volume":"134","author":"O Passa","year":"2011","journal-title":"Immu-nology"},{"issue":"10","key":"pone.0288031.ref047","doi-asserted-by":"crossref","first-page":"e46117","DOI":"10.1371\/journal.pone.0046117","article-title":"Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma","volume":"7","author":"K Huse","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"pone.0288031.ref048","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3109\/10428194.2014.924119","article-title":"Repressed BMP signaling reactivates NKL homeobox gene MSX1 in a T-ALL subset","volume":"56","author":"S Nagel","year":"2015","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"pone.0288031.ref049","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1182\/blood-2006-11-059881","article-title":"Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells","volume":"111","author":"JR Flavell","year":"2008","journal-title":"Blood"},{"issue":"53","key":"pone.0288031.ref050","doi-asserted-by":"crossref","first-page":"41328","DOI":"10.1074\/jbc.M110.146852","article-title":"MicroRNA-155 targets SMAD2 and modulates the response of macro-phages to transforming growth factor-{beta}","volume":"285","author":"F Louafi","year":"2010","journal-title":"J Biol Chem"},{"key":"pone.0288031.ref051","doi-asserted-by":"crossref","first-page":"e0231639","DOI":"10.1371\/journal.pone.0231639","article-title":"Interleukin-10 control of pre-miR155 maturation involves CELF2","volume":"15","author":"J.S.J. Yoon","year":"2020","journal-title":"PLoS ONE"},{"issue":"10","key":"pone.0288031.ref052","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.3324\/haematol.2012.061770","article-title":"ETS1 encoding a transcription factor involved in B-cell differentiation is recurrently deleted and down-regulated in classical Hodgkin\u2019s lymphoma","volume":"97","author":"BM Overbeck","year":"2012","journal-title":"Haematologica"},{"issue":"4","key":"pone.0288031.ref053","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1007\/s11033-021-07106-1","article-title":"The role of microRNA-155 in glomerular endothelial cell injury induced by high glucose","volume":"49","author":"K He","year":"2022","journal-title":"Mol Biol Rep"},{"issue":"13","key":"pone.0288031.ref054","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1182\/blood-2013-01-475772","article-title":"Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma","volume":"122","author":"P Bonetti","year":"2013","journal-title":"Blood"},{"issue":"1","key":"pone.0288031.ref055","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/s13046-021-02159-3","article-title":"ASB2 is a direct target of FLI1 that sustains NF-\u03baB pathway activation in germinal center-derived diffuse large B-cell lymphoma","volume":"40","author":"G Sartori","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"pone.0288031.ref056","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1074\/jbc.M705262200","article-title":"Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1","volume":"283","author":"SA John","year":"2008","journal-title":"J Biol Chem"},{"issue":"6550","key":"pone.0288031.ref057","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/377635a0","article-title":"Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene","volume":"377","author":"JC Bories","year":"1995","journal-title":"Nature"},{"issue":"2","key":"pone.0288031.ref058","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.4049\/jimmunol.0900455","article-title":"Initiation of antigen receptor-dependent differentiation into plasma cells by calmodulin inhibition of E2A","volume":"183","author":"J Hauser","year":"2009","journal-title":"J Immunol"},{"issue":"3","key":"pone.0288031.ref059","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.4049\/jimmunol.181.3.1644","article-title":"The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice","volume":"181","author":"XK Zhang","year":"2008","journal-title":"J Immunol"},{"issue":"3\u20134","key":"pone.0288031.ref060","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/hon.764","article-title":"Evidence of abortive plasma cell differentiation in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma","volume":"23","author":"M Buettner","year":"2005","journal-title":"Hematol Oncol"},{"issue":"6","key":"pone.0288031.ref061","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3324\/haematol.2010.031138","article-title":"Classical Hodgkin\u2019s lymphoma shows epigenetic features of abortive plasma cell differentiation","volume":"96","author":"V Seitz","year":"2011","journal-title":"Haematologica"},{"issue":"19","key":"pone.0288031.ref062","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1093\/nar\/gkg785","article-title":"Requirements for selective recruitment of Ets proteins and activation of mb-1\/Ig-alpha gene transcription by Pax-5 (BSAP)","volume":"31","author":"H Maier","year":"2003","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"pone.0288031.ref063","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1200\/JCO.2014.57.7080","article-title":"Diffuse large B-cell lymphoma classification system that associates normal B-cell subset phenotypes with prognosis","volume":"33","author":"K Dybk\u00e6r","year":"2015","journal-title":"J Clin Oncol"},{"issue":"12","key":"pone.0288031.ref064","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/ni.3299","article-title":"Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages","volume":"16","author":"D Casero","year":"2015","journal-title":"Nat Immunol"},{"issue":"6","key":"pone.0288031.ref065","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.celrep.2019.01.041","article-title":"RNA-seq signatures normalized by mRNA abundance allow absolute deconvolution of human immune cell types","volume":"26","author":"G Monaco","year":"2019","journal-title":"Cell Rep"},{"issue":"6","key":"pone.0288031.ref066","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/j.jaci.2019.01.047","article-title":"Gene expression signatures of circulating human type 1, 2, and 3 innate lymphoid cells","volume":"143","author":"S Li","year":"2019","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"pone.0288031.ref067","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.cell.2017.02.021","article-title":"Systemic human ILC precursors provide a substrate for tissue ILC differentiation","volume":"168","author":"AI Lim","year":"2017","journal-title":"Cell"},{"issue":"10","key":"pone.0288031.ref068","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1084\/jem.20080809","article-title":"Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis","volume":"205","author":"V Brune","year":"2008","journal-title":"J Exp Med"},{"issue":"17","key":"pone.0288031.ref069","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1182\/blood-2012-06-439570","article-title":"Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma","volume":"120","author":"C Steidl","year":"2012","journal-title":"Blood"},{"key":"pone.0288031.ref070","doi-asserted-by":"crossref","first-page":"420","DOI":"10.12688\/f1000research.111175.2","article-title":"DSMZCellDive: Diving into high-throughput cell line data","volume":"11","author":"J Koblitz","year":"2022","journal-title":"F1000Res"},{"key":"pone.0288031.ref071","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1186\/gb-2007-8-9-r183","article-title":"DAVID Gene functional classification tool: A novel biological module-centric algorithm to functionally analyze large gene list","volume":"8","author":"D.W. Huang","year":"2007","journal-title":"Genome Biol"},{"key":"pone.0288031.ref072","article-title":"Guide to leukemia-lymphoma cell lines, 2nd ed","author":"H.G. 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