{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:18:20Z","timestamp":1747196300676,"version":"3.40.5"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Objective<\/jats:title><jats:p>In people, the dose of propofol (DOP) required for procedural sedation and anesthesia decreases significantly with age. The objective of this study was to determine if the DOP required to perform endotracheal intubation decreases with age in dogs.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Study design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Animals<\/jats:title><jats:p>1397 dogs.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Methods<\/jats:title><jats:p>Data from dogs anesthetized at referral center (2017\u20132020) were analyzed with three multivariate linear regression models with backward elimination using a combination of either absolute age, physiologic age, or life expectancy (ratio between age at the time of anesthetic event and expected age of death for each breed obtained from previous literature) as well as other factors as independent variables, and DOP as the dependent variable. The DOP for each quartile of life expectancy (&lt;25%, 25\u201350%, 50\u201375%, 75\u2013100%, &gt;100%) was compared using one-way ANOVA. Significance was set at alpha = 0.025.<\/jats:p><\/jats:sec><jats:sec id=\"sec005\"><jats:title>Results<\/jats:title><jats:p>Mean age was 7.2 \u00b1 4.1 years, life expectancy 59.8 \u00b1 33%, weight 19 \u00b1 14 kg, and DOP 3.76 \u00b1 1.8 mg kg<jats:sup>-1<\/jats:sup>. Among age models, only life expectancy was a predictor of DOP (-0.37 mg kg<jats:sup>-1<\/jats:sup>;<jats:italic>P<\/jats:italic>= 0.013) but of minimal clinical importance. The DOP by life age expectancy quartile was 3.9 \u00b1 2.3, 3.8 \u00b1 1.8, 3.6 \u00b1 1.8, 3.7 \u00b1 1.7, and 3.4 \u00b1 1.6 mg kg<jats:sup>-1<\/jats:sup>, respectively (<jats:italic>P<\/jats:italic>= 0.20). Yorkshire Terrier, Chihuahua, Maltese, mixed breed dogs under 10 kg, and Shih Tzu required higher DOP. Status of neutered male, ASA E, and Boxer, Labrador and Golden Retriever breeds decreased DOP, along with certain premedication drugs.<\/jats:p><\/jats:sec><jats:sec id=\"sec006\"><jats:title>Conclusions and clinical relevance<\/jats:title><jats:p>In contrast to what is observed in people, an age cut-off predictive of DOP does not exist. Percentage of elapsed life expectancy along with other factors such as breed, premedication drug, emergency procedure, and reproductive status significantly alter DOP. 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