{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:27:54Z","timestamp":1773455274823,"version":"3.50.1"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["90-cc-0168"],"award-info":[{"award-number":["90-cc-0168"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013130","name":"Center for Neuroscience and Regenerative Medicine","doi-asserted-by":"publisher","award":["HU0001190035"],"award-info":[{"award-number":["HU0001190035"]}],"id":[{"id":"10.13039\/100013130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Abnormalities of postural sway have been extensively reported in traumatic brain injury (TBI). However, the underlying neural correlates of balance disturbances in TBI remain to be elucidated. Studies in children with TBI have reported associations between the Sensory Organization Test (SOT) and measures of white matter (WM) integrity with diffusion tensor imaging (DTI) in brain areas responsible for multisensory integration. This study seeks to replicate those associations in adults as well as explore relationships between DTI and the Limits of Stability (LOS) Test. Fifty-six participants (43\u00b117 years old) with a history of TBI were tested 30 days to 5 years post-TBI. This study confirmed results in children for associations between the SOT and the medial lemniscus as well as middle cerebellar peduncle, and revealed additional associations with the posterior thalamic radiation. Additionally, this study found significant correlations between abnormal LOS scores and impaired WM integrity in the cingulum, corpus callosum, corticopontine and corticospinal tracts, fronto-occipital fasciculi, longitudinal fasciculi, medial lemniscus, optic tracts and thalamic radiations. Our findings indicate the involvement of a broad range of WM tracts in the control of posture, and demonstrate the impact of TBI on balance via disruptions to WM integrity.<\/jats:p>","DOI":"10.1371\/journal.pone.0288727","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T18:54:58Z","timestamp":1701111298000},"page":"e0288727","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations between white matter integrity and postural control in adults with traumatic brain injury"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-7941","authenticated-orcid":true,"given":"Cris","family":"Zampieri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob B.","family":"Leary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pashtun","family":"Shahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Damiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Shu","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dzung L.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leighton","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"issue":"7","key":"pone.0288727.ref001","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/026990596124205","article-title":"Prevalence of impairments 5 years after a head injury, and their relationship with disabilities and outcome","volume":"10","author":"F Masson","year":"1996","journal-title":"Brain Inj"},{"issue":"3","key":"pone.0288727.ref002","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/02699050500488041","article-title":"Dizziness after traumatic brain injury: overview and measurement in the clinical setting","volume":"20","author":"F Maskell","year":"2006","journal-title":"Brain Inj"},{"issue":"2","key":"pone.0288727.ref003","first-page":"239","article-title":"The relevance of clinical balance assessment tools to differentiate balance deficits.","volume":"46","author":"M Mancini","year":"2010","journal-title":"Eur Jo Phys Rehabil Med"},{"issue":"3","key":"pone.0288727.ref004","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/00042752-200107000-00009","article-title":"Postural stability assessment following concussion: one piece of the puzzle.","volume":"11","author":"KM Guskiewicz","year":"2001","journal-title":"Clin J Sport Med"},{"key":"pone.0288727.ref005","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/apmr.2003.50034","article-title":"An assessment of gait and balance deficits after traumatic brain injury","volume":"84","author":"JR Basford","year":"2003","journal-title":"Arch Phys Med Rehabil"},{"issue":"7","key":"pone.0288727.ref006","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1682\/JRRD.2007.01.0001","article-title":"Objectively assessing balance deficits after TBI: Role of computerized posturography","volume":"44","author":"TC Pickett","year":"2007","journal-title":"J Rehabil Res Dev"},{"issue":"9","key":"pone.0288727.ref007","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3109\/09638288.2011.619624","article-title":"Associations among self-reported balance problems, post-concussion symptoms and performance-based tests: a longitudinal follow-up study.","volume":"34","author":"I Kleffelgaard","year":"2012","journal-title":"Disabil Rehabil"},{"key":"pone.0288727.ref008","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.medengphy.2005.05.005","article-title":"Comparison of subjective and objective measurements of balance disorders following traumatic brain injury","volume":"28","author":"KR Kaufman","year":"2006","journal-title":"Med Eng & Phys"},{"key":"pone.0288727.ref009","first-page":"280","volume-title":"Handbook of Balance Function Testing.","author":"LM Nashner","year":"1997"},{"key":"pone.0288727.ref010","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/MAO.0b013e318210b8fa","article-title":"Evidence of central and peripheral vestibular pathology in blast-related traumatic brain injury","volume":"32","author":"MR Scherer","year":"2011","journal-title":"Otol. 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