{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:01:59Z","timestamp":1784307719450,"version":"3.55.0"},"reference-count":13,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Smoking is a risk factor for chronic obstructive pulmonary disease (COPD). Few studies have assessed the causal relationship between smoking and COPD using Mendelian randomization.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Exposure and outcome datasets were obtained from the IEU Open GWAS project (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/gwas.mrcieu.ac.uk\/\" xlink:type=\"simple\">https:\/\/gwas.mrcieu.ac.uk\/<\/jats:ext-link>). The exposure data set includes smoking (ever smoke, smoking\/smokers in household, exposure to tobacco smoke at home). The outcome data set includes COPD susceptibility and acute COPD admissions. The main methods of Mendelian randomization analysis are weighted median method and MR-Egger method. Heterogeneity and polymorphism analyses were performed to ensure the accuracy of the results.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Resluts<\/jats:title>\n<jats:p>ever smoke increased the risk of COPD prevalence, and ever smoke and smoking\/smokers in household increased the risk of acute COPD admission. <jats:bold>Conclusion<\/jats:bold><\/jats:p>\n<jats:p>Therefore, we should enhance the management of nonpharmacological prescription of COPD to reduce the individual incidence.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0288783","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T17:30:11Z","timestamp":1690565411000},"page":"e0288783","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Application of mendelian randomization to study the causal relationship between smoking and the risk of chronic obstructive pulmonary disease"],"prefix":"10.1371","volume":"18","author":[{"given":"Yuenuo","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-6878","authenticated-orcid":true,"given":"Wei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"pone.0288783.ref001","doi-asserted-by":"crossref","first-page":"101936","DOI":"10.1016\/j.eclinm.2023.101936","article-title":"Global burden of chronic respiratory diseases and risk factors, 1990\u20132019: an update from the Global Burden of Disease Study 2019.","volume":"59","author":"GBD 2019 Chronic Respiratory Diseases 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smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis","volume":"314","author":"N Vij","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"issue":"9","key":"pone.0288783.ref009","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1136\/thoraxjnl-2015-206938","article-title":"Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study.","volume":"70","author":"WC Tan","year":"2015","journal-title":"Thorax"},{"key":"pone.0288783.ref010","doi-asserted-by":"crossref","first-page":"102055","DOI":"10.1016\/j.redox.2021.102055","article-title":"Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD.","volume":"45","author":"KP Maremanda","year":"2021","journal-title":"Redox 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