{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:26:29Z","timestamp":1764937589683,"version":"3.40.5"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vice-chancellor for Research of Arak University of Medical Sciences"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Visfatin, a colony-enhancing factor (pre-B-cell), is an inflammatory biomarker that is secreted from a different number of cells and appears to have some proinflammatory or immune-regulating effects. The aim of this study was to compare maternal saliva visfatin levels in women with preterm and term delivery. In This case-control study, women in labor before 37 weeks of gestation were the case group (n = 40) and women in labor after 37 weeks of gestation were in control group (n = 40). The saliva of the participants was sampled and maternal saliva visfatin level was measured by ELISA test. In this study, 80 pregnant women were studied in case and control groups. The mean age of case and control group was 29.1\u00b16.9 and 30.55\u00b15.3 years, respectively. The results revealed that the mean maternal saliva visfatin level in the preterm group (4.75\u00b12.2) is significantly (p = 0.001) lower than that in term birth group (6.7\u00b13.1). The results of adjusted logistic regression revealed that after adjusting for GDM, preeclampsia, pre pregnancy BMI and weight gain, the mean of maternal saliva visfatin level in the preterm group is significantly lower than that in the term group (p = 0.026). Considering that during the term pregnancy visfatin levels increase and visfatin may play a role in initiating labor, in our study due to the high visfatin level in case group although the level of maternal saliva visfatin was lower than the control group but high levels of visfatin in the case group can represent the role of visfatin in initiating labor and due to this issue can be use the role of this adipokine for early diagnosis of preterm delivery can be used to prevent, treat and improve the prognosis of this disease. Also, this study is the first study to compare the maternal saliva visfatin level between SGA and AGA group and there is no difference between these groups.<\/jats:p>","DOI":"10.1371\/journal.pone.0288786","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T17:26:25Z","timestamp":1689614785000},"page":"e0288786","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal saliva visfatin level in term and preterm labor: A case control study"],"prefix":"10.1371","volume":"18","author":[{"given":"Khadijeh","family":"Nasri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Mehrabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojtaba","family":"Bayani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4434-561X","authenticated-orcid":true,"given":"Amir","family":"Almasi-Hashiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"issue":"4","key":"pone.0288786.ref001","first-page":"681","article-title":"Lack of association of NAMPT rs9770242 and rs59744560 polymorphisms with disease susceptibility and cardiovascular risk in patients with rheumatoid arthritis","volume":"29","author":"M Garc\u00eda-Berm\u00fadez","year":"2011","journal-title":"Clinical and experimental rheumatology"},{"issue":"6","key":"pone.0288786.ref002","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.exphem.2013.02.008","article-title":"NAMPT\/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity","volume":"41","author":"SU Venkateshaiah","year":"2013","journal-title":"Experimental hematology"},{"key":"pone.0288786.ref003","doi-asserted-by":"crossref","first-page":"19094","DOI":"10.1038\/srep19094","article-title":"Strong association of the polymorphisms in PBEF1 and knee OA risk: a two-stage population-based study in China.","volume":"6","author":"M Chu","year":"2016","journal-title":"Scientific reports."},{"issue":"2","key":"pone.0288786.ref004","first-page":"1431","article-title":"Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor","volume":"14","author":"B Samal","year":"1994","journal-title":"Mol Cell Biol"},{"issue":"4","key":"pone.0288786.ref005","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/CS20070196","article-title":"Role of adiponectin and PBEF\/visfatin as regulators of inflammation: involvement in obesity-associated diseases","volume":"114","author":"H Tilg","year":"2008","journal-title":"Clinical science (London, England: 1979)."},{"issue":"9","key":"pone.0288786.ref006","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1902\/jop.2011.100690","article-title":"Gingival crevicular fluid and serum visfatin concentration: their relationship in periodontal health and disease","volume":"82","author":"AR Pradeep","year":"2011","journal-title":"Journal of periodontology"},{"volume-title":"Williams Obstetrics 23rd Edition","year":"2010","author":"F Cunningham","key":"pone.0288786.ref007"},{"journal-title":"Preterm labour and birth","article-title":"National Collaborating Centre for Women\u2019s Children\u2019s Health","year":"2015","key":"pone.0288786.ref008"},{"year":"2007","author":"RM Kliegman","key":"pone.0288786.ref009"},{"issue":"7","key":"pone.0288786.ref010","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1053\/j.semperi.2017.07.009","article-title":"Epidemiology of preterm birth.","volume":"41","author":"SE Purisch","year":"2017","journal-title":"Seminars in perinatology."},{"issue":"6","key":"pone.0288786.ref011","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00404-014-3367-5","article-title":"Would it be too late? 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