{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:36:34Z","timestamp":1790778994965,"version":"4.1.0"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Cardiorespiratory fitness is a key component of health-related fitness. It is a necessary focus of improvement, especially for those that have poor fitness and are classed as untrained. However, much research has shown individuals respond differentially to identical training programs, suggesting the involvement of a genetic component in individual exercise responses. Previous research has focused predominantly on a relatively low number of candidate genes and their overall influence on exercise responsiveness. However, examination of gene-specific alleles may provide a greater level of understanding. Accordingly, this study aimed to investigate the associations between cardiorespiratory fitness and an individual\u2019s genotype following a field-based endurance program within a previously untrained population. Participants (age: 29 \u00b1 7 years, height: 175 \u00b1 9 cm, mass: 79 \u00b1 21 kg, body mass index: 26 \u00b1 7 kg\/m<jats:sup>2<\/jats:sup>) were randomly assigned to either a training (n = 21) or control group (n = 24). The training group completed a periodized running program for 8-weeks (duration: 20-30-minutes per session, intensity: 6\u20137 Borg Category-Ratio-10 scale rating, frequency: 3 sessions per week). Both groups completed a Cooper 12-minute run test to estimate cardiorespiratory fitness at baseline, mid-study, and post-study. One thousand single nucleotide polymorphisms (SNPs) were assessed <jats:italic>via<\/jats:italic> saliva sample collections. Cooper run distance showed a significant improvement (0.23 \u00b1 0.17 km [11.51 \u00b1 9.09%], <jats:italic>p<\/jats:italic> &lt; 0.001, ES = 0.48 [95%CI: 0.16\u20130.32]), following the 8-week program, whilst controls displayed no significant changes (0.03 \u00b1 0.15 km [1.55 \u00b1 6.98%], <jats:italic>p<\/jats:italic> = 0.346, ES = 0.08, [95%CI: -0.35\u20130.95]). A significant portion of the inter-individual variation in Cooper scores could be explained by the number of positive alleles a participant possessed (r = 0.92, R<jats:sup>2<\/jats:sup> = 0.85, <jats:italic>p<\/jats:italic> &lt; 0.001). These findings demonstrate the relative influence of key allele variants on an individual\u2019s responsiveness to endurance training.<\/jats:p>","DOI":"10.1371\/journal.pone.0288996","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T17:44:11Z","timestamp":1689875051000},"page":"e0288996","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Responsiveness to endurance training can be partly explained by the number of favorable single nucleotide polymorphisms an individual possesses"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3285-2892","authenticated-orcid":true,"given":"Henry C.","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don R.","family":"Keiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Swain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun L.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3169-2041","authenticated-orcid":true,"given":"Justin D.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan A.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"issue":"4_suppl","key":"pone.0288996.ref001","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/1359786810382057","article-title":"Mortality trends in the general population: the importance of cardiorespiratory fitness","volume":"24","author":"DC Lee","year":"2010","journal-title":"Journal of psychopharmacology"},{"issue":"1","key":"pone.0288996.ref002","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00005768-200001000-00012","article-title":"Limiting factors for maximum oxygen uptake and determinants of endurance performance","volume":"32","author":"DR Bassett","year":"2000","journal-title":"Medicine and science in sports and exercise"},{"issue":"10","key":"pone.0288996.ref003","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s40279-015-0365-0","article-title":"Effectiveness of high-intensity interval training (HIT) and continuous endurance training for VO 2max improvements: a systematic review and meta-analysis of controlled trials.","volume":"45","author":"Z Milanovi\u0107","year":"2015","journal-title":"Sports medicine."},{"issue":"10","key":"pone.0288996.ref004","doi-asserted-by":"crossref","first-page":"e0249501","DOI":"10.1371\/journal.pone.0249501","article-title":"Do exercise-associated genes explain phenotypic variance in the three components of fitness? 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Bandyopadhyay","year":"2015","journal-title":"Biology of sport"},{"key":"pone.0288996.ref010","article-title":"Borg\u2019s perceived exertion and pain scales","author":"G. Borg","year":"1998","journal-title":"Human kinetics"},{"issue":"6","key":"pone.0288996.ref011","first-page":"370","article-title":"Athletic performance in relation to training load","volume":"95","author":"C Foster","year":"1996","journal-title":"Wisconsin medical journal"},{"issue":"s2","key":"pone.0288996.ref012","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1123\/IJSPP.2016-0388","article-title":"Monitoring training loads: the past, the present, and the future","volume":"12","author":"C Foster","year":"2017","journal-title":"International journal of sports physiology and performance"},{"issue":"1","key":"pone.0288996.ref013","first-page":"109","article-title":"A new approach to monitoring exercise training","volume":"15","author":"C Foster","year":"2001","journal-title":"The Journal of Strength & Conditioning Research"},{"issue":"1","key":"pone.0288996.ref014","first-page":"59","article-title":"Does the timing of measurement alter session-RPE in boxers","volume":"13","author":"MC Uchida","year":"2014","journal-title":"Journal of sports science & medicine"},{"issue":"6","key":"pone.0288996.ref015","article-title":"ACSM position stand: the recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults","volume":"30","author":"ML Pollock","year":"1998","journal-title":"Journals AZ> Medicine & Science"},{"issue":"05","key":"pone.0288996.ref016","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-0030-1248283","article-title":"Influence of cardiopulmonary exercise testing protocol and resting VO2 assessment on% Hrmax,% HRR,% VO2max and% VO2R relationships.","volume":"31","author":"FA Cunha","year":"2010","journal-title":"International Journal of Sports Medicine"},{"issue":"3","key":"pone.0288996.ref017","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00421-007-0508-6","article-title":"Prediction of maximal oxygen uptake from the ratings of perceived exertion and heart rate during a perceptually-regulated sub-maximal exercise test in active and sedentary participants","volume":"101","author":"J Faulkner","year":"2007","journal-title":"European journal of applied physiology"},{"issue":"1","key":"pone.0288996.ref018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00421-009-1093-7","article-title":"Prediction of maximal oxygen uptake from submaximal ratings of perceived exertion and heart rate during a continuous exercise test: the efficacy of RPE 13.","volume":"107","author":"DM Lambrick","year":"2009","journal-title":"European journal of applied physiology."},{"issue":"5","key":"pone.0288996.ref019","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/bib\/bbx008","article-title":"Selecting between-sample RNA-Seq normalization methods from the perspective of their assumptions","volume":"19","author":"C Evans","year":"2018","journal-title":"Briefings in bioinformatics"},{"key":"pone.0288996.ref020","first-page":"18","volume-title":"Statistical power analysis Jbr the behavioral. Sciences.","author":"J. Cohen","year":"1988"},{"issue":"32","key":"pone.0288996.ref021","doi-asserted-by":"crossref","first-page":"19151","DOI":"10.1073\/pnas.1915454117","article-title":"When possible, report a Fisher-exact P value and display its underlying null randomization distribution","volume":"117","author":"MA Bind","year":"2020","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1\/2","key":"pone.0288996.ref022","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2307\/2332323","article-title":"Note on an exact treatment of contingency, goodness of fit and other problems of significance","volume":"38","author":"GH Freeman","year":"1951","journal-title":"Biometrika"},{"issue":"7","key":"pone.0288996.ref023","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/gepi.20410","article-title":"Strengthening the Reporting of Genetic Association Studies (STREGA)\u2014an extension of the STROBE statement.","volume":"33","author":"J 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hypertension","volume":"10","author":"R Oguro","year":"2010","journal-title":"Geriatrics & gerontology international"},{"issue":"11","key":"pone.0288996.ref036","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1096\/fba.2019-00016","article-title":"Alpha\u2010Klotho, a critical protein for lung health, is not expressed in normal lung.","volume":"1","author":"J Zhang","year":"2019","journal-title":"FASEB BioAdvances."},{"issue":"5","key":"pone.0288996.ref037","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.bone.2005.06.003","article-title":"Analysis of variation in expression of autosomal dominant osteopetrosis type 2: searching for modifier genes","volume":"37","author":"K Chu","year":"2005","journal-title":"Bone"},{"issue":"11","key":"pone.0288996.ref038","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1359\/JBMR.050717","article-title":"Polymorphisms of the CLCN7 gene are associated with BMD in women","volume":"20","author":"U Pettersson","year":"2005","journal-title":"Journal of Bone and Mineral Research"},{"key":"pone.0288996.ref039","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.trsl.2018.08.003","article-title":"Changes in CDKN2A\/2B expression associate with T-cell phenotype modulation in atherosclerosis and type 2 diabetes mellitus.","volume":"203","author":"\u00c1 Vinu\u00c9","year":"2019","journal-title":"Translational Research."},{"key":"pone.0288996.ref040","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s00018-017-2505-1","article-title":"BACE2 suppression promotes \u03b2-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression","volume":"74","author":"G Alcarraz-Viz\u00e1n","year":"2017","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"7","key":"pone.0288996.ref041","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1097\/HJH.0000000000000208","article-title":"The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss","volume":"32","author":"NC Ward","year":"2014","journal-title":"Journal of hypertension"},{"issue":"3","key":"pone.0288996.ref042","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ymgme.2008.11.161","article-title":"A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men","volume":"96","author":"Z Fu","year":"2009","journal-title":"Molecular genetics and metabolism"},{"issue":"1","key":"pone.0288996.ref043","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/jnc.13099","article-title":"Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia\u2010like conditions: key roles of the transcription factors GATA 2, Sp1 and TBP","volume":"134","author":"V Gupta","year":"2015","journal-title":"Journal of neurochemistry"},{"issue":"2","key":"pone.0288996.ref044","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jaci.2015.06.045","article-title":"Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity","volume":"137","author":"SP Saunders","year":"2016","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"suppl_4","key":"pone.0288996.ref045","doi-asserted-by":"crossref","first-page":"iv4","DOI":"10.1093\/rheumatology\/kel313","article-title":"The heart and cardiovascular manifestations in rheumatoid arthritis","volume":"45","author":"AE Voskuyl","year":"2006","journal-title":"Rheumatology"},{"issue":"1","key":"pone.0288996.ref046","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/emph\/eoy033","article-title":"Is antagonistic pleiotropy ubiquitous in aging biology?.","volume":"2018","author":"SN Austad","year":"2018","journal-title":"Evolution, medicine, and public health."},{"issue":"7","key":"pone.0288996.ref047","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1073\/pnas.0808376106","article-title":"Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation.","volume":"106","author":"R McDermott","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"17","key":"pone.0288996.ref048","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1093\/hmg\/ddl192","article-title":"Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors.","volume":"15","author":"JK Pinsonneault","year":"2006","journal-title":"Human molecular genetics"},{"issue":"12","key":"pone.0288996.ref049","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1038\/sj.npp.1301028","article-title":"Monoamine oxidase A activity and norepinephrine level in hippocampus determine hyperwheel running in SPORTS rats","volume":"31","author":"M Morishima","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"pone.0288996.ref050","article-title":"Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain.","volume":"363","author":"M Miranda","year":"2019","journal-title":"Frontiers in cellular neuroscience"},{"issue":"9","key":"pone.0288996.ref051","doi-asserted-by":"crossref","first-page":"e23531","DOI":"10.1371\/journal.pone.0023531","article-title":"Studies of metabolic phenotypic correlates of 15 obesity associated gene variants","volume":"6","author":"CH Sandholt","year":"2011","journal-title":"PloS one"},{"key":"pone.0288996.ref052","first-page":"10","article-title":"The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases.","author":"B Xu","year":"2022","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"3","key":"pone.0288996.ref053","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0163-7827(96)00006-9","article-title":"Cellular fatty acid-binding proteins: their function and physiological significance","volume":"35","author":"JF Glatz","year":"1996","journal-title":"Progress in lipid research"},{"issue":"11","key":"pone.0288996.ref054","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1161\/ATVBAHA.113.301588","article-title":"Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle","volume":"33","author":"T Iso","year":"2013","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"1","key":"pone.0288996.ref055","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tem.2017.10.011","article-title":"Molecular regulation of fatty acid oxidation in skeletal muscle during aerobic exercise","volume":"29","author":"AM Lundsgaard","year":"2018","journal-title":"Trends in Endocrinology & Metabolism"},{"issue":"3","key":"pone.0288996.ref056","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.ejhg.5201964","article-title":"The ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes","volume":"16","author":"SM Roth","year":"2008","journal-title":"European Journal of Human Genetics"},{"issue":"3","key":"pone.0288996.ref057","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1086\/377590","article-title":"ACTN3 genotype is associated with human elite athletic performance","volume":"73","author":"N Yang","year":"2003","journal-title":"The American Journal of human genetics"},{"issue":"1","key":"pone.0288996.ref058","doi-asserted-by":"crossref","first-page":"e0147330","DOI":"10.1371\/journal.pone.0147330","article-title":"No evidence of a common DNA variant profile specific to world class endurance athletes","volume":"11","author":"T Rankinen","year":"2016","journal-title":"PloS one"},{"issue":"5","key":"pone.0288996.ref059","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1123\/ijspp.2014-0205","article-title":"Elimination of influences of the ACTN3 R577X variant on oxygen uptake by endurance training in healthy individuals","volume":"10","author":"MS Silva","year":"2015","journal-title":"International journal of sports physiology and performance"},{"issue":"7915","key":"pone.0288996.ref060","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41586-022-04828-5","article-title":"An exercise-inducible metabolite that suppresses feeding and obesity","volume":"606","author":"VL Li","year":"2022","journal-title":"Nature"},{"issue":"1","key":"pone.0288996.ref061","doi-asserted-by":"crossref","first-page":"e0115524","DOI":"10.1371\/journal.pone.0115524","article-title":"Expression and function of connexin 43 in human gingival wound healing and fibroblasts.","volume":"10","author":"R Tarzemany","year":"2015","journal-title":"PloS One."},{"issue":"7","key":"pone.0288996.ref062","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3390\/nu12072121","article-title":"Identifying Interactions between Dietary Sodium, Potassium, Sodium\u2013Potassium Ratios, and FGF5 rs16998073 Variants and Their Associated Risk for Hypertension in Korean Adults.","volume":"12","author":"H Jeong","year":"2020","journal-title":"Nutrients"},{"issue":"3","key":"pone.0288996.ref063","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00438-022-01889-z","article-title":"Genetic susceptibility analysis of FGF5 polymorphism to preeclampsia in Chinese Han population","volume":"297","author":"Q Xin","year":"2022","journal-title":"Molecular Genetics and Genomics"},{"issue":"3","key":"pone.0288996.ref064","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cell.2005.08.035","article-title":"Divergence of melanocortin pathways in the control of food intake and energy expenditure","volume":"123","author":"N Balthasar","year":"2005","journal-title":"Cell"},{"issue":"12","key":"pone.0288996.ref065","doi-asserted-by":"crossref","first-page":"e52344","DOI":"10.1371\/journal.pone.0052344","article-title":"Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption.","volume":"7","author":"D Corella","year":"2012","journal-title":"PloS one"},{"issue":"2","key":"pone.0288996.ref066","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.gene.2015.03.013","article-title":"The association of MC4R rs17782313 polymorphism with dietary intake in Iranian adults","volume":"563","author":"A Khalilitehrani","year":"2015","journal-title":"Gene"},{"key":"pone.0288996.ref067","doi-asserted-by":"crossref","first-page":"144372","DOI":"10.1016\/j.gene.2020.144372","article-title":"Association between MC4R rs17782313 genotype and obesity: A 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