{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T22:11:21Z","timestamp":1778451081015,"version":"3.51.4"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010621","name":"Uniwersytet Medyczny w Lublinie","doi-asserted-by":"publisher","award":["PBsd270"],"award-info":[{"award-number":["PBsd270"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Accommodation is a phenomenon of the eyeball, which consists of adapting to view objects at different distances. The main aim of this study is to evaluate the effect of accommodations on the musculoskeletal system in myopic and emmetropic subjects. To date, the effect of accommodative paralysis on the musculoskeletal system has not been studied. The research hypothesis based on the current research reports is that accommodation affects the musculoskeletal system in myopic and emmetropic subjects. A smaller aim of the study is to evaluate the effect of unilateral accommodative palsy on the musculoskeletal system in myopic and emmetropic subjects. According to the authors of the previous reports, unilateral accommodative palsy will affect increased musculoskeletal asymmetry in myopic and emmetropic subjects. The surface electromyography (sEMG) of the musculoskeletal system will be performed by using the Noraxon Ultium DTS 8-K MR 3 myo Muscle Master Edition. Cycloftyal (10 mg\/ml, eye drops, solution) will be used to paralyze accommodation. After the paralysis of unilateral accommodation, the test will be repeated. Both-sided accommodation will be paralyzed next, and the test will be repeated. The study may provide insight into the effects of accommodation on the musculoskeletal system, and it may also help in understanding the connections between these systems.<\/jats:p>","DOI":"10.1371\/journal.pone.0289347","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T17:34:35Z","timestamp":1690565675000},"page":"e0289347","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Study protocol: Accommodative effects on the musculoskeletal system"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-0641","authenticated-orcid":true,"given":"Grzegorz","family":"Zieli\u0144ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Matysik-Wo\u017aniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Paj\u0105k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-6103","authenticated-orcid":true,"given":"Micha\u0142","family":"Ginszt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Rejdak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Gawda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"pone.0289347.ref001","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1167\/iovs.63.6.24","article-title":"Ciliary Muscle Dimension Changes With Accommodation Vary in Myopia and Emmetropia","volume":"63","author":"D. 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Neuronal Interact"},{"key":"pone.0289347.ref036","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s12891-019-2655-4","article-title":"Abdominal Trunk Muscle Weakness and Its Association with Chronic Low Back Pain and Risk of Falling in Older Women","volume":"20","author":"S. Kato","year":"2019","journal-title":"BMC Musculoskelet. Disord"},{"key":"pone.0289347.ref037","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/joa.13666","article-title":"Accessory Heads of the Biceps Brachii Muscle: A Systematic Review and Meta-Analysis","volume":"241","author":"M. Benes","year":"2022","journal-title":"J. Anat"},{"key":"pone.0289347.ref038","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jcm.2021.02.001","article-title":"Supernumerary Head of the Biceps Brachii Muscle: An Anatomic Variant With Clinical Implications","volume":"20","author":"D. Enix","year":"2021","journal-title":"J. Chiropr. 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