{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:51:10Z","timestamp":1778601070227,"version":"3.51.4"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Recently, several inflammatory markers, including the uric acid to HDL cholesterol ratio (UHR), triglyceride\/HDL cholesterol ratio (THR), systemic inflammatory index (SII), and C-reactive protein to albumin ratio (CAR), have been reported to be associated with inflammatory conditions. However, their collective role in sacroiliitis has not been extensively studied. This study aims to investigate the general characteristics and inflammatory markers in patients with and without sacroiliitis, and to observe any differences in these parameters in subjects with active and chronic sacroiliitis. Patient with sacroiliitis who showed up in the Radiology Department of Abant Izzet Baysal University Hospital were enrolled. Patients diagnosed with sacroiliitis based on clinical symptoms, physical examination, and conventional radiography or MRI findings were included in the sacroiliitis group. Patients without sacroiliitis who present with back pain or hip pain but have normal radiographic findings were included in the control group. General characteristics, including age, sex, body mass index (BMI), medical history, and disease duration, were collected from all participants. Blood samples were collected to measure inflammatory markers, including UHR, THR, SII, and CAR. The collected data were compared between sacroiliitis and control groups. Subgroup analysis was also performed to compare the inflammatory markers between subjects with active and chronic sacroiliitis. The median UHR of the sacroiliitis and control subjects were 11% (3\u201320%) and 7% (3\u201313%), respectively (p&lt;0.001). Serum UHR was significantly and positively correlated with CRP (r: 0.4, p = 0.001) and ferritin (r: 0.17, p = 0.045) levels. In ROC analysis, a UHR level higher than 8% has an 81% sensitivity and 64% specificity in detecting sacroiliitis (AUC: 0.8, p&lt;0.001, 95% CI: 0.72\u20130.84). In conclusion, we suggest that UHR could provide useful data as an additional diagnostic tool in patients with sacroiliitis.<\/jats:p>","DOI":"10.1371\/journal.pone.0289624","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T17:23:03Z","timestamp":1698081783000},"page":"e0289624","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Could serum uric acid to HDL cholesterol ratio predict sacroiliitis?"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-763X","authenticated-orcid":true,"given":"Melike Elif","family":"Kalfaoglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"issue":"5s","key":"pone.0289624.ref001","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/j.jacr.2017.01.048","article-title":"ACR Appropriateness Criteria(\u00ae) Chronic Back Pain Suspected Sacroiliitis-Spondyloarthropathy","volume":"14","author":"SA Bernard","year":"2017","journal-title":"Journal of the American College of Radiology: JACR"},{"issue":"2","key":"pone.0289624.ref002","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41584-020-00552-4","article-title":"Axial spondyloarthritis: concept, construct, classification and implications for therapy","volume":"17","author":"PC Robinson","year":"2021","journal-title":"Nature reviews Rheumatology"},{"issue":"4","key":"pone.0289624.ref003","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1148\/rg.334125025","article-title":"Sacroiliitis associated with axial spondyloarthropathy: new concepts and latest trends","volume":"33","author":"M Navallas","year":"2013","journal-title":"Radiographics: a review publication of the Radiological Society of North America, Inc"},{"issue":"6","key":"pone.0289624.ref004","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1136\/annrheumdis-2016-210770","article-title":"2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis","volume":"76","author":"D van der Heijde","year":"2017","journal-title":"Annals of the rheumatic diseases"},{"issue":"4","key":"pone.0289624.ref005","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2478\/rjim-2021-0023","article-title":"Hashimoto\u2019s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio","volume":"59","author":"O Kurtkulagi","year":"2021","journal-title":"Romanian journal of internal medicine = Revue roumaine de medecine interne"},{"issue":"1","key":"pone.0289624.ref006","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1590\/1806-9282.65.1.9","article-title":"Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus","volume":"65","author":"MZ Kocak","year":"2019","journal-title":"Revista da Associacao Medica Brasileira (1992)"},{"issue":"5","key":"pone.0289624.ref007","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1080\/13685538.2019.1678126","article-title":"Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus","volume":"23","author":"G Aktas","year":"2020","journal-title":"The aging male: the official journal of the International Society for the Study of the Aging Male"},{"issue":"3","key":"pone.0289624.ref008","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/prm2.12080","article-title":"Correlation between serum triglyceride to HDL cholesterol ratio and blood pressure in patients with primary hypertension","volume":"11","author":"O Kurtkulagi","year":"2022","journal-title":"Precision Medical Sciences"},{"issue":"3","key":"pone.0289624.ref009","first-page":"163","article-title":"The Triglyceride\/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2","volume":"73","author":"N Babic","year":"2019","journal-title":"Medical archives (Sarajevo, Bosnia and Herzegovina)"},{"issue":"6","key":"pone.0289624.ref010","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.pcd.2021.08.015","article-title":"Does C-reactive protein to serum Albumin Ratio correlate with diabEtic nephropathy in patients with Type 2 dIabetes MEllitus? 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