{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:13:28Z","timestamp":1782180808993,"version":"3.54.5"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001829","name":"Universiteit Utrecht","doi-asserted-by":"publisher","award":["Focus and Massa"],"award-info":[{"award-number":["Focus and Massa"]}],"id":[{"id":"10.13039\/501100001829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Colour agnosia is a disorder that impairs colour knowledge (naming, recognition) despite intact colour perception. Previously, we have identified the first and only-known family with hereditary developmental colour agnosia. The aim of the current study was to explore genomic regions and candidate genes that potentially cause this trait in this family. For three family members with developmental colour agnosia and three unaffected family members CGH-array analysis and exome sequencing was performed, and linkage analysis was carried out using DominantMapper, resulting in the identification of 19 cosegregating chromosomal regions. Whole exome sequencing resulted in 11 rare coding variants present in all affected family members with developmental colour agnosia and absent in unaffected members. These variants affected genes that have been implicated in neural processes and functions (<jats:italic>CACNA2D4<\/jats:italic>, <jats:italic>DDX25<\/jats:italic>, <jats:italic>GRINA<\/jats:italic>, <jats:italic>MYO15A<\/jats:italic>) or that have an indirect link to brain function, development or disease (<jats:italic>MAML2<\/jats:italic>, <jats:italic>STAU1<\/jats:italic>, <jats:italic>TMED3<\/jats:italic>, <jats:italic>RABEPK<\/jats:italic>), and a remaining group lacking brain expression or involved in non-neural traits (<jats:italic>DEPDC7<\/jats:italic>, <jats:italic>OR1J1<\/jats:italic>, <jats:italic>OR8D4<\/jats:italic>). Although this is an explorative study, the small set of candidate genes that could serve as a starting point for unravelling mechanisms of higher level cognitive functions and cortical specialization, and disorders therein such as developmental colour agnosia.<\/jats:p>","DOI":"10.1371\/journal.pone.0290013","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T17:28:29Z","timestamp":1694021309000},"page":"e0290013","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of candidate genes for developmental colour agnosia in a single unique family"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6683-0267","authenticated-orcid":true,"given":"Tanja C. W.","family":"Nijboer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen V. S.","family":"Hessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijs W.","family":"van Haaften","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine J.","family":"van Zandvoort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"van der Spek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Troelstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7818-1396","authenticated-orcid":true,"given":"Carolien G. F.","family":"de Kovel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby P. C.","family":"Koeleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"van der Zwaag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva H.","family":"Brilstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8619-6168","authenticated-orcid":true,"given":"J. Peter H.","family":"Burbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"issue":"1","key":"pone.0290013.ref001","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2006.12.021","article-title":"Trekking across the brain: the journey of neuronal migration","volume":"128","author":"R Ayala","year":"2007","journal-title":"Cell"},{"issue":"8","key":"pone.0290013.ref002","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/hmg\/7.8.1327","article-title":"Human doublecortin (DCX) and the homologous gene in mouse encode a putative Ca2+-dependent signaling protein which is mutated in human X-linked neuronal migration defects","volume":"7","author":"K Sossey-Alaoui","year":"1998","journal-title":"Hum Mol Genet"},{"issue":"13","key":"pone.0290013.ref003","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/hmg\/7.13.2029","article-title":"LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformation","volume":"7","author":"DT Pilz","year":"1998","journal-title":"Hum Mol Genet"},{"issue":"3","key":"pone.0290013.ref004","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.gde.2010.12.003","article-title":"Curiouser and curiouser: genetic disorders of cortical specialization","volume":"21","author":"KJ Mitchell","year":"2011","journal-title":"Curr Opin Genet Dev"},{"key":"pone.0290013.ref005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev-genom-090413-025600","article-title":"The diverse genetic landscape of neurodevelopmental disorders","volume":"15","author":"WF Hu","year":"2014","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"1","key":"pone.0290013.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0028-3932(91)90090-U","article-title":"Two systems for colour-naming defects: Verbal disconnection vs colour imagery disorder","volume":"29","author":"LP De Vreese","year":"1991","journal-title":"Neuropsychologia"},{"issue":"8","key":"pone.0290013.ref007","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.neuropsychologia.2007.01.021","article-title":"A familial factor in the development of colour agnosia","volume":"45","author":"TCW Nijboer","year":"2007","journal-title":"Neuropsychologia"},{"issue":"8","key":"pone.0290013.ref008","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.neuropsychologia.2005.12.004","article-title":"Covert colour processing in colour agnosia","volume":"44","author":"TCW Nijboer","year":"2006","journal-title":"Neuropsychologia"},{"issue":"6","key":"pone.0290013.ref009","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0010-9452(08)70503-3","article-title":"Developmental colour agnosia","volume":"43","author":"MJE van Zandvoort","year":"2007","journal-title":"Cortex"},{"key":"pone.0290013.ref010","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1055\/s-2000-13181","article-title":"Disorders of visual recognition","volume":"20","author":"E. De Renzi","year":"2000","journal-title":"Seminars in Neurology. Semin Neurol"},{"issue":"2","key":"pone.0290013.ref011","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/02643290600989541","article-title":"Colour agnosia impairs the recognition of natural but not of non-natural scenes","volume":"24","author":"TCW Nijboer","year":"2007","journal-title":"Cogn Neuropsychol"},{"issue":"11","key":"pone.0290013.ref012","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/sj.ejhg.5201896","article-title":"Guidelines for molecular karyotyping in constitutional genetic diagnosis","volume":"15","author":"JR Vermeesch","year":"2007","journal-title":"Eur J Hum Genet"},{"issue":"11","key":"pone.0290013.ref013","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1002\/ajmg.a.35580","article-title":"Unstable transmission of a familial complex chromosome rearrangement","volume":"158 A","author":"E Van Binsbergen","year":"2012","journal-title":"Am J Med Genet Part A"},{"issue":"12","key":"pone.0290013.ref014","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/humu.21597","article-title":"DominantMapper: Rule-based analysis of SNP data for rapid mapping of dominant diseases in related nuclear families","volume":"32","author":"IM Carr","year":"2011","journal-title":"Hum Mutat"},{"issue":"7","key":"pone.0290013.ref015","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/ng.2324","article-title":"Dominant missense mutations in ABCC9 cause Cant\u00fasyndrome","volume":"44","author":"M Harakalova","year":"2012","journal-title":"Nat Genet"},{"issue":"12","key":"pone.0290013.ref016","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1038\/nprot.2011.396","article-title":"Multiplexed array-based and in-solution genomic enrichment for flexible and cost-effective targeted next-generation sequencing","volume":"6","author":"M Harakalova","year":"2011","journal-title":"Nat Protoc"},{"issue":"11","key":"pone.0290013.ref017","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nmeth.1516","article-title":"Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples","volume":"7","author":"IJ Nijman","year":"2010","journal-title":"Nat Methods"},{"issue":"21","key":"pone.0290013.ref018","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1093\/hmg\/ddq337","article-title":"Transcriptional profiling of fibroblasts from patients with mutations in MCT8 and comparative analysis with the human brain transcriptome","volume":"19","author":"WE Visser","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"1","key":"pone.0290013.ref019","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2043-9113-2-19","article-title":"Huvariome: a web server resource of whole genome next-generation sequencing allelic frequencies to aid in pathological candidate gene selection","volume":"2","author":"A Stubbs","year":"2012","journal-title":"J Clin Bioinforma"},{"issue":"7772","key":"pone.0290013.ref020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41586-019-1506-7","article-title":"Conserved cell types with divergent features in human versus mouse cortex","volume":"573","author":"RD Hodge","year":"2019","journal-title":"Nature"},{"issue":"7729","key":"pone.0290013.ref021","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41586-018-0654-5","article-title":"Shared and distinct transcriptomic cell types across neocortical areas","volume":"563","author":"B Tasic","year":"2018","journal-title":"Nature"},{"issue":"2","key":"pone.0290013.ref022","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nn.4216","article-title":"Adult mouse cortical cell taxonomy revealed by single cell transcriptomics","volume":"19","author":"B Tasic","year":"2016","journal-title":"Nat Neurosci"},{"issue":"7319","key":"pone.0290013.ref023","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","author":"DL Altshuler","year":"2010","journal-title":"Nature"},{"issue":"8","key":"pone.0290013.ref024","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/ng.3021","article-title":"Whole-genome sequence variation, population structure and demographic history of the Dutch population","volume":"46","author":"LC Francioli","year":"2014","journal-title":"Nat Genet"},{"issue":"2","key":"pone.0290013.ref025","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ejhg.2013.118","article-title":"The Genome of the Netherlands: Design, and project goals","volume":"22","author":"DI Boomsma","year":"2014","journal-title":"Eur J Hum Genet"},{"issue":"9","key":"pone.0290013.ref026","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/gim.2014.180","article-title":"SG-ADVISER CNV: Copy-number variant annotation and interpretation","volume":"17","author":"GA Erikson","year":"2015","journal-title":"Genet Med"},{"issue":"5","key":"pone.0290013.ref027","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1086\/508944","article-title":"Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy","volume":"79","author":"KA Wycisk","year":"2006","journal-title":"Am J Hum Genet"},{"issue":"3","key":"pone.0290013.ref028","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.ophtha.2015.09.045","article-title":"Mutations in CACNA2D4 cause distinctive retinal dysfunction in humans","volume":"123","author":"R Ba-Abbad","year":"2016","journal-title":"Ophthalmology"},{"issue":"8","key":"pone.0290013.ref029","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1167\/iovs.06-0271","article-title":"Structural and functional abnormalities of retinal ribbon synapses due to Cacna2d4 mutation","volume":"47","author":"KA Wycisk","year":"2006","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"6","key":"pone.0290013.ref030","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.neuron.2017.02.021","article-title":"The Auxiliary Calcium Channel Subunit \u03b12\u03b44 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors","volume":"93","author":"Y Wang","year":"2017","journal-title":"Neuron"},{"key":"pone.0290013.ref031","article-title":"Genetic associations between voltage-gated calcium channels and autism spectrum disorder: A systematic review","volume":"13","author":"X Liao","year":"2020","journal-title":"Molecular Brain. BioMed Central Ltd"},{"issue":"4","key":"pone.0290013.ref032","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/ajmg.b.32053","article-title":"Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders","volume":"159 B","author":"MJ Van Den Bossche","year":"2012","journal-title":"Am J Med Genet Part B Neuropsychiatr Genet"},{"issue":"4","key":"pone.0290013.ref033","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.cell.2010.09.047","article-title":"A genome-wide Drosophila screen for heat nociception identifies \u03b12\u03b43 as an evolutionarily conserved pain gene","volume":"143","author":"GG Neely","year":"2010","journal-title":"Cell"},{"issue":"1","key":"pone.0290013.ref034","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrn702","article-title":"Anomalous perception in synaesthesia: A cognitive neuroscience perspective","volume":"3","author":"AN Rich","year":"2002","journal-title":"Nat Rev Neurosci"},{"issue":"5368","key":"pone.0290013.ref035","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.280.5368.1444","article-title":"Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene","volume":"80280","author":"FJ Probst","year":"1998","journal-title":"Science"},{"issue":"5368","key":"pone.0290013.ref036","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1126\/science.280.5368.1447","article-title":"Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3","volume":"80280","author":"A Wang","year":"1998","journal-title":"Science"},{"issue":"1","key":"pone.0290013.ref037","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16846-9","article-title":"Combined genetic approaches yield a 48% diagnostic rate in a large cohort of French hearing-impaired patients","volume":"7","author":"D Baux","year":"2017","journal-title":"Sci Rep"},{"issue":"9","key":"pone.0290013.ref038","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2174\/1570159X18666200303104235","article-title":"Role of Grina\/Nmdara1 in the Central Nervous System Diseases","volume":"18","author":"K Chen","year":"2021","journal-title":"Curr Neuropharmacol"},{"key":"pone.0290013.ref039","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pnpbp.2012.12.010","article-title":"Gene expression analysis of novel genes in the prefrontal cortex of major depressive disorder subjects","volume":"43","author":"DB Goswami","year":"2013","journal-title":"Prog Neuro-Psychopharmacology Biol Psychiatry"},{"issue":"1\u20132","key":"pone.0290013.ref040","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11010-011-0877-3","article-title":"Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system","volume":"357","author":"JA Nielsen","year":"2011","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"pone.0290013.ref041","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/humu.23368","article-title":"A loss-of-function homozygous mutation in DDX59 implicates a conserved DEAD-box RNA helicase in nervous system development and function","volume":"39","author":"V Salpietro","year":"2018","journal-title":"Hum Mutat"},{"issue":"3","key":"pone.0290013.ref042","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neuron.2020.01.042","article-title":"Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development","volume":"106","author":"AL Lennox","year":"2020","journal-title":"Neuron"},{"issue":"17","key":"pone.0290013.ref043","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1073\/pnas.0401855101","article-title":"Gonadotropin-regulated testicular RNA helicase (GRTH\/Ddx25) is essential for spermatid development and completion of spermatogenesis","volume":"101","author":"CH Tsai-Morris","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"15","key":"pone.0290013.ref044","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1093\/hmg\/ddz079","article-title":"Targeted knock-in mice with a human mutation in GRTH\/DDX25 reveals the essential role of phosphorylated GRTH in spermatid development during spermatogenesis","volume":"28","author":"R Kavarthapu","year":"2019","journal-title":"Hum Mol Genet"},{"issue":"12","key":"pone.0290013.ref045","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/molehr\/gam065","article-title":"Polymorphism of the GRTH\/DDX25 gene in normal and infertile Japanese men: A missense mutation associated with loss of GRTH phosphorylation","volume":"13","author":"CH Tsai-Morris","year":"2007","journal-title":"Mol Hum Reprod"},{"issue":"42","key":"pone.0290013.ref046","doi-asserted-by":"crossref","first-page":"16374","DOI":"10.1073\/pnas.0804583105","article-title":"A loss of function allele for murine Staufen1 leads to impairment of dendritic Staufen1-RNP delivery and dendritic spine morphogenesis","volume":"105","author":"JP Vessey","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pone.0290013.ref047","article-title":"Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis. Nat Commun","volume":"9","author":"BS Moon","year":"2018"},{"key":"pone.0290013.ref048","article-title":"Multi-omic directed networks describe features of gene regulation in aged brains and expand the set of genes driving cognitive decline","author":"S Tasaki","year":"2018","journal-title":"Front Genet"},{"issue":"6","key":"pone.0290013.ref049","doi-asserted-by":"crossref","first-page":"570","DOI":"10.2174\/138920309789630543","article-title":"Transcriptional Mechanisms by the Coregulator MAML1","volume":"10","author":"M Just Ribeiro","year":"2009","journal-title":"Curr Protein Pept Sci"},{"issue":"10","key":"pone.0290013.ref050","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/s41593-022-01160-z","article-title":"Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction","volume":"25","author":"RL Kember","year":"2022","journal-title":"Nat Neurosci"},{"issue":"7","key":"pone.0290013.ref051","doi-asserted-by":"crossref","first-page":"882","DOI":"10.15252\/emmm.201303799","article-title":"A novel genome\u2010wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT \u2010 TCF pathway modulators TMED 3 and SOX 12","volume":"6","author":"A Duquet","year":"2014","journal-title":"EMBO Mol Med"},{"key":"pone.0290013.ref052","doi-asserted-by":"crossref","DOI":"10.1038\/srep37070","article-title":"TMED3 promotes hepatocellular carcinoma progression via IL-11\/STAT3 signaling","volume":"6","author":"H Zheng","year":"2016","journal-title":"Sci Rep"},{"issue":"6","key":"pone.0290013.ref053","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.eurpsy.2015.04.001","article-title":"Further evidence of DEPDC7 DNA hypomethylation in depression: A study in adult twins","volume":"30","author":"A C\u00f3rdova-Palomera","year":"2015","journal-title":"Eur Psychiatry"},{"issue":"12","key":"pone.0290013.ref054","article-title":"The dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-\u03baB activation","volume":"9","author":"EL D\u2019Andrea","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"pone.0290013.ref055","first-page":"7332","article-title":"DEPDC7 inhibits cell proliferation, migration and invasion in hepatoma cells","volume":"14","author":"Z Liao","year":"2017","journal-title":"Oncol Lett"},{"issue":"3","key":"pone.0290013.ref056","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.rbmo.2014.04.017","article-title":"A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia","volume":"29","author":"CM Seabra","year":"2014","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"pone.0290013.ref057","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ajhg.2011.03.004","article-title":"Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel","volume":"88","author":"A Gonz\u00e1lez-P\u00e9rez","year":"2011","journal-title":"Am J Hum Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0290013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T17:29:04Z","timestamp":1694021344000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0290013"}},"subtitle":[],"editor":[{"given":"Nejat","family":"Mahdieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,9,6]]},"references-count":57,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0290013","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,6]]}}}