{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:01:56Z","timestamp":1790949716673,"version":"4.1.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K19733"],"award-info":[{"award-number":["21K19733"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>It is unknown whether patients with chronic musculoskeletal pain (CMP) show autonomic dysregulation after exercise, and the interventional effects of exercise on the autonomic dysregulation have not been elucidated. The objectives of this study were to reveal acute autonomic responses after aerobic and resistance exercises and the interventional effects of both exercises on autonomic dysregulation in patients with CMP.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>A systematic search using nine electronic databases was performed based on three key search terms: \u201cchronic musculoskeletal pain,\u201d \u201cautonomic nervous system,\u201d and \u201cexercise.\u201d Data were extracted from measurements of the autonomic nervous system and pain.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>We found a total of 1170 articles; 17 were finally included, incorporating 12 observational and five interventional studies. Although a comparator has not been specified, healthy controls were compared to patients with CMP in observational studies. Three of five interventional studies were pre-post study with healthy controls as a comparator or no controls. The other two interventional studies were randomized controlled trial with a different treatment e.g., stretching. There were four good, 10 fair, and three poor-quality articles. The total number of participants was 617, of which 551 were female. There was high heterogeneity among the five disease conditions and nine outcome measures. Following one-time exposure to aerobic and resistance exercises, abnormal autonomic responses (sympathetic activation and parasympathetic withdrawal), which were absent in healthy controls, were observed in patients with CMP. The effects of aerobic and resistance exercise as long-term interventions were unclear since we identified both positive effects and no change in the autonomic activities in patients with CMP.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>This study indicates dysfunctional autonomic responses following one-time exposure to exercise and inconsistent interventional effects in the autonomic activities in patients with CMP. Appropriate therapeutic dose is necessary for studying the management of autonomic regulation and pain after exercise.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0290061","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T17:21:46Z","timestamp":1692033706000},"page":"e0290061","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Autonomic responses to aerobic and resistance exercise in patients with chronic musculoskeletal pain: A systematic 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Boutevillain","year":"2017","journal-title":"PLOS ONE"},{"key":"pone.0290061.ref008","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neucli.2020.11.002","article-title":"Conditioned pain modulation-A comprehensive review","volume":"51","author":"S Ramaswamy","year":"2021","journal-title":"Neurophysiol Clin"},{"key":"pone.0290061.ref009","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1113\/JP282013","article-title":"The association between pain-induced autonomic reactivity and descending pain control is mediated by the periaqueductal grey","volume":"599","author":"E Makovac","year":"2021","journal-title":"J Physiol"},{"key":"pone.0290061.ref010","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.2522\/ptj.20130597","article-title":"Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation","volume":"94","author":"KE Hannibal","year":"2014","journal-title":"Phys 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Gavi","year":"2014","journal-title":"PLOS ONE"},{"key":"pone.0290061.ref036","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.apmr.2010.07.003","article-title":"The effects of 12 weeks of resistance exercise training on disease severity and autonomic modulation at rest and after acute leg resistance exercise in women with fibromyalgia","volume":"91","author":"JD Kingsley","year":"2010","journal-title":"Arch Phys Med Rehabil"},{"issue":"Suppl 88","key":"pone.0290061.ref037","first-page":"S41","article-title":"Vagal modulation and symptomatology following a 6-month aerobic exercise program for women with fibromyalgia","volume":"33","author":"B Sa\u00f1udo","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"pone.0290061.ref038","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ejpain.2007.07.007","article-title":"Attenuated adrenergic responses to exercise in women with fibromyalgia\u2014a controlled study","volume":"12","author":"L Giske","year":"2008","journal-title":"Eur J Pain"},{"key":"pone.0290061.ref039","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2340\/16501977-0597","article-title":"Evidence of reduced sympatho-adrenal and hypothalamic-pituitary activity during static muscular work in patients with fibromyalgia","volume":"42","author":"D Kadetoff","year":"2010","journal-title":"J Rehabil Med"},{"key":"pone.0290061.ref040","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejpain.2005.12.013","article-title":"The effects of static muscular contraction on blood pressure, heart rate, pain ratings and pressure pain thresholds in healthy individuals and patients with fibromyalgia","volume":"11","author":"D Kadetoff","year":"2007","journal-title":"Eur J Pain."},{"key":"pone.0290061.ref041","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00392-010-0187-x","article-title":"Evaluation of cardiac autonomic functions in patients with ankylosing spondylitis via heart rate 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Figueroa","year":"2008","journal-title":"Clin Physiol Funct Imaging"},{"key":"pone.0290061.ref048","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF02556303","article-title":"Decreased vagal power during treadmill walking in patients with chronic fatigue syndrome","volume":"6","author":"DL Cordero","year":"1996","journal-title":"Clin Auton Res"},{"key":"pone.0290061.ref049","doi-asserted-by":"crossref","first-page":"R190","DOI":"10.1186\/ar3519","article-title":"Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia","volume":"13","author":"RP da Cunha Ribeiro","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"pone.0290061.ref050","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1471-2474-13-146","article-title":"Effect of muscle load tasks with maximal isometric contractions on oxygenation of the trapezius muscle and sympathetic nervous activity in females with chronic neck and shoulder pain","volume":"13","author":"Y Shiro","year":"2012","journal-title":"BMC Musculoskelet Disord"},{"key":"pone.0290061.ref051","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fpubh.2017.00258","article-title":"An overview of heart rate variability metrics and norms","volume":"5","author":"F Shaffer","year":"2017","journal-title":"Front Public Health"},{"key":"pone.0290061.ref052","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/cpf.12102","article-title":"Heart rate recovery: autonomic determinants, methods of assessment and association with mortality and cardiovascular diseases","volume":"34","author":"T Pe\u00e7anha","year":"2014","journal-title":"Clin Physiol Funct Imaging"},{"issue":"Suppl 88","key":"pone.0290061.ref053","first-page":"S53","article-title":"Relationship between sympathetic activity and pain intensity in fibromyalgia","volume":"33","author":"AR Zamun\u00e9r","year":"2015","journal-title":"Clin Exp 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