{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:49:59Z","timestamp":1790214599743,"version":"4.1.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Hashimoto\u2019s thyroiditis (HT) is a prevalent autoimmune disease of thyroid gland with a shared immunological mechanism with mood disorders. Affective temperament (AT) is a biologically determined personality trait that has been linked to mood disorders. The aim of this study was to examine the association between dominant AT and levels of psychosomatic symptoms in women newly diagnosed with HT in comparison to clinically healthy subjects.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The observational cross-sectional study with nested case control study was involving 146 consecutive participants, who were divided into three groups. The two study groups consisted of women with HT (73), including 49 with hypothyroid HT and 24 with euthyroid HT, and the third group was a control group of healthy participants (73). The Serbian version of the TEMPS-A was utilized to assess AT, while the 4DSQ was used to measure psychosomatic symptoms.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The results showed that hyperthymic AT was dominant in all examined groups. The groups with HT differed from the control group in terms of depressive and cyclothymic AT. Furthermore, the study found higher levels of psychosomatic symptoms in the group with HT compared to the control group, with significant differences in distress (p = 0.005) and somatization (p = 0.023) levels. All AT was associated with levels of psychosomatic symptoms in subjects with hypothyroid HT. In contrast, in subjects with euthyroid HT, the association was only found between depressive and cyclothymic AT with distress and depression levels, as well as between somatization and cyclothymic AT. No association was found between AT and anxiety levels in subjects with euthyroid HT.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The research found differences between study groups in the association between AT and levels of psychosomatic symptoms. Further research with a larger sample size is necessary to more clearly define the associations between affective temperaments and psychosomatic symptoms in women with euthyroid and hypothyroid HT.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0290066","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T17:27:14Z","timestamp":1692120434000},"page":"e0290066","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between affective temperaments and psychosomatic symptoms in women with Hashimoto\u2019s thyroiditis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-6424","authenticated-orcid":true,"given":"Gordana","family":"Stani\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sne\u017eana","family":"Marinkovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Milin Lazovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Ignjatovi\u0107 Risti\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"issue":"4\u20135","key":"pone.0290066.ref001","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.autrev.2014.01.007","article-title":"Hashimoto thyroiditis: Clinical and diagnostic criteria","volume":"13","author":"P Caturegli","year":"2014","journal-title":"Autoimmun Rev"},{"key":"pone.0290066.ref002","doi-asserted-by":"crossref","first-page":"124264","DOI":"10.4061\/2010\/124264","article-title":"Profile of Hashimoto\u2019s Thyroiditis in Sri Lankans: Is There an Increased Risk of Ancillary Pathologies in Hashimoto\u2019s Thyroiditis?","volume":"2010","author":"EH Siriweera","year":"2010","journal-title":"J Thyroid Res"},{"issue":"6","key":"pone.0290066.ref003","doi-asserted-by":"crossref","first-page":"101367","DOI":"10.1016\/j.beem.2019.101367","article-title":"Hashimotos\u2019 thyroiditis: Epidemiology, pathogenesis, clinic and therapy","volume":"33","author":"F Ragusa","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"pone.0290066.ref004","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/thy.2007.0234","article-title":"Changed presentation of Hashimoto\u2019s thyroiditis in North-Eastern Sicily and Calabria (Southern Italy) based on a 31-year experience","volume":"18","author":"S Benvenga","year":"2008","journal-title":"Thyroid"},{"issue":"4","key":"pone.0290066.ref005","first-page":"425","article-title":"Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto\u2019s thyroiditis?","volume":"64","author":"MM Yalcin","year":"2017","journal-title":"Journals free access"},{"issue":"4","key":"pone.0290066.ref006","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/ph15040391","article-title":"Depression and Autoimmune Hypothyroidism\u2014Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines\u2014A Systematic Review.","volume":"15","author":"Z K\u043etkowsa","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"4","key":"pone.0290066.ref007","doi-asserted-by":"crossref","first-page":"e0153892","DOI":"10.1371\/journal.pone.0153892","article-title":"Aberrant Levels of Hematopoietic\/Neuronal Growth and Differentiation Factors in Euthyroid Women at Risk for Autoimmune Thyroid Disease.","volume":"11","author":"ET Massolt","year":"2016","journal-title":"PLOS ONE"},{"issue":"1","key":"pone.0290066.ref008","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1034\/j.1600-0447.2002.01250.x","article-title":"An association between depression, anxiety and thyroid function\u2014a clinical fact or an artefact?","volume":"106","author":"A Engum","year":"2002","journal-title":"Acta Psychiatr Scand"},{"issue":"6","key":"pone.0290066.ref009","first-page":"577","article-title":"Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis","volume":"75","author":"E Siegmann","journal-title":"A Systematic Review and Meta-analysis. 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