{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:42:55Z","timestamp":1773196975868,"version":"3.50.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["IP30EY025585"],"award-info":[{"award-number":["IP30EY025585"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018313","name":"Cleveland Eye Bank Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018313","name":"Cleveland Eye Bank Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018313","name":"Cleveland Eye Bank Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018313","name":"Cleveland Eye Bank Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To determine if a greater than expected number of cases (clustering) of uveal melanoma occurred within Ohio for any specific region or time period as compared to others.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Design<\/jats:title>\n<jats:p>Analysis of population database.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Ohio Cancer Incidence Surveillance System (OCISS) database (2000\u20132019) was accessed for the diagnosis of uveal melanoma using the International Classification of Disease for Oncology codes: C69.3 (choroid), C69.4 (ciliary body and iris). Counties within Ohio were grouped by geographic regions (7) and socioeconomic variables. Age- and race-standardized incidence ratios (SIR) were calculated to determine temporal or geographic clustering.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>Over the twenty-year period, the total number of uveal melanoma cases reported within Ohio were 1,617 with the overall age-adjusted annual incidence of 6.72 cases per million population (95% CI 6.30\u20137.16). There was an increase in the incidence of uveal melanoma over 20 years (p&lt;0.001) across seven geographic regions, but no significant difference in incidence rates between the regions. There was no difference in incidence based on county classification by age composition (p = 0.14) or education level (p = 0.11). Counties with a low median household income (p&lt;0.001), those classified as urban (p = 0.004), and those with a greater minority population (p = 0.004) had lower incidence. Less populated counties had a higher incidence of uveal melanoma (p&lt;0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>There is no evidence of geographic or temporal clustering of uveal melanoma within Ohio from 2000 to 2019.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0290284","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T17:27:44Z","timestamp":1692379664000},"page":"e0290284","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clustering of uveal melanoma: County wide analysis within Ohio"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-4869","authenticated-orcid":true,"given":"Leanne M.","family":"Clevenger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacquelyn D.","family":"Wrenn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Bena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guneet","family":"Sodhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Tullio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9411-0320","authenticated-orcid":true,"given":"Arun D.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"pone.0290284.ref001","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3390\/ijerph110201479","article-title":"Cancer Cluster Investigations: Review of the Past and Proposals for the Future","volume":"11","author":"M Goodman","year":"2014","journal-title":"Int J Environ Res Public Health"},{"key":"pone.0290284.ref002","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/nrc1755","article-title":"The Long Island Breast Cancer Study Project","volume":"5","author":"DM Winn","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"pone.0290284.ref003","first-page":"1","article-title":"Investigating Suspected Cancer Clusters and Responding to Community Concerns: Guidelines from CDC and the Council of State and Territorial Epidemiologists","volume":"62","author":"B Abrams","year":"2013","journal-title":"CDC Morbidity and Mortality Weekly Report (MMWR)"},{"key":"pone.0290284.ref004","unstructured":"Ocular melanoma. 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