{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:21:51Z","timestamp":1768278111540,"version":"3.49.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Leishmaniasis is a zoonotic disease transmitted by an obligate intra-macrophage protozoan of the genus <jats:italic>Leishmania<\/jats:italic> through the infective bite of a vector sandfly. This study investigated the therapeutic efficacy of farnesol, a sesquiterpene compound, for the treatment of cutaneous leishmaniasis (CL) using <jats:italic>in vivo<\/jats:italic> BALB\/c mouse model. In this study, farnesol\u2019s efficacy was compared with the standard drug, paromomycin. It was observed that farnesol significantly reduced lesion sizes and footpad thickness compared to the control group (paromomycin). Lymph node size was also significantly reduced in farnesol-treated mice, indicating its ability to control infection spread. Combination therapy with farnesol and Paromomycin did not demonstrate synergistic effects. These results highlight the potential of farnesol as an alternative therapeutic agent for CL. Further investigations are required to elucidate its mechanism of action and assess potential off-target effects. Optimization of oral delivery methods should be explored to enhance bioavailability. Overall, our findings support farnesol\u2019s efficacy in CL treatment, offering promising prospects for improved disease management.<\/jats:p>","DOI":"10.1371\/journal.pone.0290297","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T17:29:26Z","timestamp":1693243766000},"page":"e0290297","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of farnesol orally and topically against experimental cutaneous leishmaniasis: In -vivo analysis"],"prefix":"10.1371","volume":"18","author":[{"given":"Harshita","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9833-3265","authenticated-orcid":true,"given":"Rakesh","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Jhacak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirti","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritambhara","family":"Nada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"pone.0290297.ref001","first-page":"1","article-title":"History of tropical medicine, and medicine in the tropics","volume":"22","author":"G. 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