{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:28:20Z","timestamp":1780597700572,"version":"3.54.1"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"national cancer center research and development fund","award":["29-A-12"],"award-info":[{"award-number":["29-A-12"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>While the Pringle maneuver reduces intraoperative blood loss in hepatectomies, this technique can also be hepatotoxic. Hepatectomies require general anesthesia with propofol or volatile anesthetics like sevoflurane, agents known to offer multi-organ protection. However, their clinical effect after liver resection is unclear. We aimed to assess the effect of the two anesthetics on post-hepatectomy liver damage via measuring liver function tests. Fifty-six patients who underwent elective hepatectomies with the Pringle maneuver due to metastatic hepatic masses were preoperatively randomized to be anesthetized by sevoflurane or propofol. The primary and secondary outcomes were the postoperative peak levels of aspartate transaminase (AST) and alanine transaminase (ALT), respectively. Patients anesthetized by propofol exhibited significantly lower transaminases than those given sevoflurane (AST, p = 0.005; ALT, p = 0.006). The former agent significantly affected postoperative transaminases (AST hazard ratio -192.2, 95% confidence interval [-332.1 to -52.4], p = 0.00; ALT hazard ratio -140.2, 95% confidence interval [-240.0 to -40.7], p = 0.007). In conclusion, propofol had a greater hepatoprotective effect than sevoflurane as assessed by postoperative transaminases after hepatectomy with Pringle maneuver for metastatic liver tumors.<\/jats:p>","DOI":"10.1371\/journal.pone.0290327","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T17:47:56Z","timestamp":1692899276000},"page":"e0290327","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Protective effect of propofol compared with\u00a0sevoflurane\u00a0on liver function after\u00a0hepatectomy with Pringle maneuver: A randomized clinical trial"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-195X","authenticated-orcid":true,"given":"Junya","family":"Matsumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsufumi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"issue":"7","key":"pone.0290327.ref001","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/bjs.9492","article-title":"Failure to rescue as a source of variation in hospital mortality after hepatic surgery","volume":"101","author":"G Spolverato","year":"2014","journal-title":"Br J Surg"},{"issue":"10","key":"pone.0290327.ref002","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/hpb.12469","article-title":"National trends with a laparoscopic liver resection: results from a population based 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