{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:23:07Z","timestamp":1784755387130,"version":"3.55.0"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Extremadura Regional Government through the Plan Regional de Investigation de Extremadura, Spain","award":["PRI09A161"],"award-info":[{"award-number":["PRI09A161"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Intra-abdominal hypertension and abdominal compartment syndrome are common with clinically significant consequences. We investigated the pathophysiological effects of raised IAP as part of a more extensive exploratory animal study. The study design included both pneumoperitoneum and mechanical intestinal obstruction models.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>Forty-nine female swine were divided into six groups: a control group (Cr; n = 5), three pneumoperitoneum groups with IAPs of 20mmHg (Pn20; n = 10), 30mmHg (Pn30; n = 10), 40mmHg (Pn40; n = 10), and two mechanical intestinal occlusion groups with IAPs of 20mmHg (MIO20; n = 9) and 30mmHg (MIO30; n = 5).<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>There were significant changes (p&lt;0.05) noted in all organ systems, most notably systolic blood pressure (SBP) (p&lt;0.001), cardiac index (CI) (p = 0.003), stroke volume index (SVI) (p&lt;0.001), mean pulmonary airway pressure (MPP) (p&lt;0.001), compliance (p&lt;0.001), pO2 (p = 0.003), bicarbonate (p = 0.041), hemoglobin (p = 0.012), lipase (p = 0.041), total bilirubin (p = 0.041), gastric pH (p&lt;0.001), calculated glomerular filtration rate (GFR) (p&lt;0.001), and urine output (p&lt;0.001). SVV increased progressively as the IAP increased with no obvious changes in intravascular volume status. There were no significant differences between the models regarding their impact on cardiovascular, respiratory, renal and gastrointestinal systems. However, significant differences were noted between the two models at 30mmHg, with MIO30 showing worse metabolic and hematological parameters, and Pn30 and Pn40 showing a more rapid rise in creatinine.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>This study identified and quantified the impact of intra-abdominal hypertension at different pressures on several organ systems and highlighted the significance of even short-lived elevations. Two models of intra-abdominal pressure were used, with a mechanical obstruction model showing more rapid changes in metabolic and haematological changes. These may represent different underlying cellular and vascular pathophysiological processes, but this remains unclear.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0290451","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T17:25:42Z","timestamp":1693243542000},"page":"e0290451","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["The pathophysiological impact of intra-abdominal hypertension in pigs"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5237-5582","authenticated-orcid":true,"given":"Robert","family":"Wise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reitze","family":"Rodseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"P\u00e1rraga-Ros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Latorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"L\u00f3pez Albors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Correa-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-988X","authenticated-orcid":true,"given":"Francisco","family":"M. S\u00e1nchez-Margallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Eugenia Candanosa-Aranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-2899","authenticated-orcid":true,"given":"Jan","family":"Poelaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Castellanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"L. N. G. Malbrain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"issue":"2","key":"pone.0290451.ref001","first-page":"188","article-title":"Intra-abdominal hypertension in the ICU\u2013a prospective epidemiological study","volume":"88","author":"G Arabadzhiev","year":"2015","journal-title":"Clujul Med"},{"key":"pone.0290451.ref002","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13613-020-00746-9","article-title":"Intra-abdominal hypertension and abdominal compartment syndrome in patients admitted to the ICU","volume":"10","author":"M Smit","year":"2020","journal-title":"Ann. Intensive Care"},{"issue":"5","key":"pone.0290451.ref003","doi-asserted-by":"crossref","first-page":"R249","DOI":"10.1186\/cc13075","article-title":"Risk factors for intra-abdominal hypertension and abdominal compartment syndrome among adult intensive care unit patients: a systematic review and meta-analysis","volume":"17","author":"JK Holodinsky","year":"2013","journal-title":"Critical care"},{"issue":"4","key":"pone.0290451.ref004","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/CCM.0000000000003623","article-title":"Incidence, Risk Factors, and Outcomes of Intra-Abdominal Hypertension in Critically Ill Patients\u2014A Prospective Multicenter Study (IROI Study)","volume":"47","author":"The Incidence, Risk Factors, and Outcomes of Intra-Abdominal (IROI) Study Investigators","year":"2019","journal-title":"Critical Care Medicine"},{"issue":"3","key":"pone.0290451.ref005","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jcrc.2015.01.021","article-title":"The prevalence of and factors associated with intra-abdominal hypertension on admission day in critically ill pediatric patients: A multicenter study","volume":"30","author":"O Horoz","year":"2015","journal-title":"J Crit Care"},{"issue":"1","key":"pone.0290451.ref006","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/0310057X1204000107","article-title":"Incidence, risk factors and outcome associations of intra-abdominal hypertension in critically ill patients","volume":"40","author":"I Kim","year":"2012","journal-title":"Anaesth Intensive Care"},{"key":"pone.0290451.ref007","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12873-017-0120-y","article-title":"Prevalence and predictors of intra-abdominal hypertension and compartment syndrome in surgical patients in critical care units at Kenyatta National Hospital","volume":"17","author":"A Muturi","year":"2016","journal-title":"BMC Emerg Med"},{"issue":"19","key":"pone.0290451.ref008","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijsu.2015.05.014","article-title":"Intra-abdominal hypertension; incidence, prevalence and outcomes in a mixed intensive care unit: Prospective cohort study","author":"G Murtaza","year":"2015","journal-title":"Int J Surg"},{"issue":"Suppl 1","key":"pone.0290451.ref009","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/2110-5820-2-S1-S3","article-title":"Incidence and prognosis of intra-abdominal hypertension in critically ill medical patients: a prospective epidemiological study","volume":"2","author":"P Santa-Teresa","year":"2012","journal-title":"Annals of intensive care"},{"issue":"6","key":"pone.0290451.ref010","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.cjtee.2015.11.015","article-title":"Prevalence and diagnosis rate of intra-abdominal hypertension in critically ill adult patients: A single-center cross-sectional study","volume":"18","author":"H Zhang","year":"2015","journal-title":"Chin J Traumatol"},{"issue":"6","key":"pone.0290451.ref011","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1097\/CCM.0b013e31817c7a4d","article-title":"Incidence and clinical effects of intra-abdominal hypertension in critically ill patients","volume":"36","author":"MG Vidal","year":"2008","journal-title":"Critical care medicine"},{"issue":"4","key":"pone.0290451.ref012","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S1441-2772(23)02019-7","article-title":"Recognition and management of intra-abdominal hypertension and abdominal compartment syndrome","volume":"7","author":"R Nagappan","year":"2005","journal-title":"Critical care and resuscitation: journal of the Australasian Academy of Critical Care Medicine"},{"issue":"3","key":"pone.0290451.ref013","first-page":"713","article-title":"Pathophysiology of renal hemodynamics and renal cortical microcirculation in a porcine model of elevated intra-abdominal pressure","volume":"66","author":"J Wauters","year":"2009","journal-title":"The Journal of trauma"},{"issue":"5","key":"pone.0290451.ref014","doi-asserted-by":"crossref","first-page":"433","DOI":"10.5603\/AIT.2014.0064","article-title":"The polycompartment syndrome: A concise state-of-the-art review","volume":"46","author":"M Malbrain","year":"2014","journal-title":"Anaesthesiology intensive therapy"},{"issue":"67","key":"pone.0290451.ref015","first-page":"1","article-title":"The neglected role of abdominal compliance in organ-organ interactions","volume":"20","author":"M Malbrain","year":"2016","journal-title":"Critical care"},{"issue":"2","key":"pone.0290451.ref016","doi-asserted-by":"crossref","first-page":"e0148058","DOI":"10.1371\/journal.pone.0148058","article-title":"Mechanical Intestinal Obstruction in a Porcine Model: Effects of Intra-Abdominal Hypertension. A Preliminary Study","volume":"11","author":"L Correa-Martin","year":"2016","journal-title":"PloS one"},{"issue":"3","key":"pone.0290451.ref017","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00134-003-2107-2","article-title":"Different techniques to measure intra-abdominal pressure (IAP): time for a critical re-appraisal","volume":"30","author":"ML Malbrain","year":"2004","journal-title":"Intensive care medicine"},{"issue":"7","key":"pone.0290451.ref018","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1007\/s00134-013-2906-z","article-title":"Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome","volume":"39","author":"AW Kirkpatrick","year":"2013","journal-title":"Intensive care medicine"},{"issue":"1","key":"pone.0290451.ref019","first-page":"15","article-title":"Correlation between different methods of intra-abdominal pressure monitoring in varying intra-abdominal hypertension models","volume":"33","author":"RD Wise","year":"2017","journal-title":"South. Afr. j. crit. care (Online)"},{"issue":"2","key":"pone.0290451.ref020","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/CCM.0b013e3181959864","article-title":"Influence of increased intra-abdominal pressure on fluid responsiveness predicted by pulse pressure variation and stroke volume variation in a porcine model","volume":"37","author":"J Renner","year":"2009","journal-title":"Crit Care Med"},{"issue":"1","key":"pone.0290451.ref021","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1186\/cc9980","article-title":"Pulse pressure variation and stroke volume variation during increased intra-abdominal pressure: an experimental study","volume":"15","author":"D Jacques","year":"2011","journal-title":"Crit Care"},{"issue":"2","key":"pone.0290451.ref022","doi-asserted-by":"crossref","first-page":"129","DOI":"10.5582\/bst.2015.01029","article-title":"The impact of intra-abdominal pressure on the stroke volume variation and plethysmographic variability index in patients undergoing laparoscopic cholecystectomy","volume":"9","author":"F Liu","year":"2015","journal-title":"Biosci Trends"},{"issue":"1","key":"pone.0290451.ref023","first-page":"25","article-title":"Modification of stroke volume variation with increased intra-abdominal pressure in normovolemic porcine model","volume":"27","author":"TE Deloya","year":"2013","journal-title":"Med Crit"},{"issue":"4","key":"pone.0290451.ref024","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1164\/rccm.200209-1060OC","article-title":"An increase of abdominal pressure increases pulmonary edema in oleic acid-induced lung injury","volume":"169","author":"M Quintel","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"4 Pt 1","key":"pone.0290451.ref025","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1164\/ajrccm.156.4.97-01052","article-title":"Impairment of lung and chest wall mechanics in patients with acute respiratory distress syndrome: role of abdominal distension","volume":"156","author":"VM Ranieri","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"pone.0290451.ref026","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1152\/jappl.1991.70.6.2611","article-title":"Abdominal distension alters regional pleural pressures and chest wall mechanics in pigs in vivo","volume":"70","author":"T Mutoh","year":"1991","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"pone.0290451.ref027","doi-asserted-by":"crossref","first-page":"R128","DOI":"10.1186\/cc9095","article-title":"Commonly applied positive end-expiratory pressures do not prevent functional residual capacity decline in the setting of intra-abdominal hypertension: a pig model","volume":"14","author":"A Regli","year":"2010","journal-title":"Crit Care"},{"issue":"6","key":"pone.0290451.ref028","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1097\/CCM.0b013e31824e0e80","article-title":"Matching positive end-expiratory pressure to intra-abdominal pressure prevents end-expiratory lung volume decline in a pig model of intra-abdominal hypertension","volume":"40","author":"A Regli","year":"2012","journal-title":"Crit Care Med"},{"issue":"2","key":"pone.0290451.ref029","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1152\/jappl.1992.72.2.575","article-title":"Volume infusion produces abdominal distension, lung compression, and chest wall stiffening in pigs","volume":"72","author":"T Mutoh","year":"1992","journal-title":"J Appl Physiol (1985)"},{"key":"pone.0290451.ref030","first-page":"763181","article-title":"Relationship between Abdominal Pressure, Pulmonary Compliance, and Cardiac Preload in a Porcine Model","volume":"2012","author":"J Wauters","year":"2012","journal-title":"Crit Care Res Pract"},{"issue":"5","key":"pone.0290451.ref031","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/bja\/aeq211","article-title":"Ventilation-perfusion distributions and gas exchange during carbon dioxide-pneumoperitoneum in a porcine model","volume":"105","author":"CM Strang","year":"2010","journal-title":"Br J Anaesth"},{"issue":"5","key":"pone.0290451.ref032","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1034\/j.1399-6576.2002.460513.x","article-title":"Effect of CO2 pneumoperitoneum on ventilation-perfusion relationships during laparoscopic cholecystectomy","volume":"46","author":"L Andersson","year":"2002","journal-title":"Acta Anaesthesiol Scand"},{"key":"pone.0290451.ref033","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13613-019-0522-y","article-title":"Ventilation in patients with intra-abdominal hypertension: what every critical care physician needs to know","volume":"9","author":"A. Regli","year":"2019","journal-title":"Ann. Intensive Care"},{"issue":"5","key":"pone.0290451.ref034","doi-asserted-by":"crossref","first-page":"R208","DOI":"10.1186\/cc11840","article-title":"Matching positive end-expiratory pressure to intra-abdominal pressure improves oxygenation in a porcine sick lung model of intra-abdominal hypertension","volume":"16","author":"A Regli","year":"2012","journal-title":"Crit Care"},{"issue":"3","key":"pone.0290451.ref035","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3906\/sag-1304-23","article-title":"Effects of intraabdominal pressure on mean platelet volume during laparoscopic cholecystectomy","volume":"44","author":"RB Celep","year":"2014","journal-title":"Turk J Med Sci"},{"issue":"3","key":"pone.0290451.ref036","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jbspin.2007.06.016","article-title":"Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis","volume":"75","author":"B Kisacik","year":"2008","journal-title":"Joint Bone Spine"},{"issue":"4","key":"pone.0290451.ref037","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/09537100902856781","article-title":"An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume","volume":"20","author":"O Y\u00fcksel","year":"2009","journal-title":"Platelets"},{"key":"pone.0290451.ref038","first-page":"245","article-title":"Mean platelet volume as a marker of future cardiovascular disease risk in pregnant women with impaired fasting glucose and impaired glucose tolerance","volume":"42","author":"N K\u00f6\u015f\u00fc\u015f","year":"2012","journal-title":"Turk J Med Sci"},{"key":"pone.0290451.ref039","first-page":"39","article-title":"Mean platelet volume as a fibrosis marker in patients with chronic hepatitis C","volume":"43","author":"H Karaman","year":"2013","journal-title":"Turk J Med Sci"},{"issue":"4","key":"pone.0290451.ref040","first-page":"243","article-title":"Association between mean platelet volume and autonomic nervous system functions: Increased mean platelet volume reflects sympathetic overactivity","volume":"9","author":"O Ozdemir","year":"2004","journal-title":"Exp Clin Cardiol"},{"issue":"3","key":"pone.0290451.ref041","first-page":"427","article-title":"Mean platelet volume in diagnosis of acute appendicitis in children","volume":"11","author":"S Bilici","year":"2011","journal-title":"Afr Health Sci"},{"issue":"6","key":"pone.0290451.ref042","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1016\/j.ejim.2011.04.005","article-title":"The predictive value of mean platelet volume in differential diagnosis of non-functional pancreatic neuroendocrine tumors from pancreatic adenocarcinomas","volume":"22","author":"K Karaman","year":"2011","journal-title":"Eur J Intern Med"},{"issue":"5","key":"pone.0290451.ref043","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1161\/ATVBAHA.110.221788","article-title":"Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease","volume":"31","author":"G Slavka","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"pone.0290451.ref044","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/jcp.36.6.693","article-title":"Increased mean platelet volume in septicaemia","volume":"36","author":"J Van der Lelie","year":"1983","journal-title":"J Clin Pathol"},{"issue":"3","key":"pone.0290451.ref045","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2141.1982.tb01947.x","article-title":"Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function","volume":"50","author":"CB Thompson","year":"1982","journal-title":"Br J Haematol"},{"issue":"1","key":"pone.0290451.ref046","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.thromres.2006.09.002","article-title":"Assessment of mean platelet volume in coronary artery disease\u2014what does it mean?","volume":"120","author":"CJ Boos","year":"2007","journal-title":"Thromb Res"},{"issue":"8780","key":"pone.0290451.ref047","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/0140-6736(91)92719-I","article-title":"Influence of platelet size on outcome after myocardial infarction","volume":"338","author":"JF Martin","year":"1991","journal-title":"Lancet"},{"issue":"8787","key":"pone.0290451.ref048","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0140-6736(92)90060-G","article-title":"Platelet size and venous disease","volume":"339","author":"PR Thomas","year":"1992","journal-title":"Lancet"},{"issue":"7","key":"pone.0290451.ref049","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/EJA.0000000000000064","article-title":"Central venous-to-arterial carbon dioxide partial pressure difference in early resuscitation from septic shock: a prospective observational study","volume":"31","author":"J Mallat","year":"2014","journal-title":"Eur J Anaesthesiol"},{"issue":"1","key":"pone.0290451.ref050","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13054-015-0858-0","article-title":"Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference is associated with lactate evolution in the hemodynamic resuscitation process in early septic shock","volume":"19","author":"J Mesquida","year":"2015","journal-title":"Crit Care"},{"issue":"12","key":"pone.0290451.ref051","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1007\/s00134-008-1199-0","article-title":"Central venous-to-arterial carbon dioxide difference: an additional target for goal-directed therapy in septic shock?","volume":"34","author":"F Vall\u00e9e","year":"2008","journal-title":"Intensive Care Med"},{"issue":"9","key":"pone.0290451.ref052","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s00134-013-2998-5","article-title":"Resuscitation of patients with septic shock: please \"mind the gap\"!","volume":"39","author":"B Vallet","year":"2013","journal-title":"Intensive Care Med"},{"issue":"4","key":"pone.0290451.ref053","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1152\/jappl.2000.89.4.1317","article-title":"Venoarterial CO2 difference during regional ischemic or hypoxic hypoxia","volume":"89","author":"B Vallet","year":"2000","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"pone.0290451.ref054","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1053\/j.ajkd.2010.08.034","article-title":"Intra-abdominal Hypertension and Abdominal Compartment Syndrome","volume":"57","author":"JJ De Waele","year":"2011","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"pone.0290451.ref055","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13613-020-00746-9","article-title":"Intra-abdominal hypertension and abdominal compartment syndrome in patients admitted to the ICU","volume":"10","author":"M Smit","year":"2020","journal-title":"Ann Intensive Care"},{"issue":"4","key":"pone.0290451.ref056","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1681\/ASN.2010121222","article-title":"Renal dysfunction associated with intra-abdominal hypertension and the abdominal compartment syndrome","volume":"22","author":"H Mohmand","year":"2011","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"pone.0290451.ref057","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.ackd.2016.03.002","article-title":"Intra-Abdominal Hypertension and Abdominal Compartment Syndrome: An Underappreciated Cause of Acute Kidney Injury","volume":"23","author":"DM Patel","year":"2016","journal-title":"Adv Chronic Kidney Dis"},{"key":"pone.0290451.ref058","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13613-021-00851-3","article-title":"Fluid-induced harm in the hospital: look beyond volume and start considering sodium. From physiology towards recommendations for daily practice in hospitalized adults","volume":"11","author":"N. Van Regenmortel","year":"2021","journal-title":"Ann. Intensive Care"},{"key":"pone.0290451.ref059","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13613-020-00679-3","article-title":"Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA)","volume":"10","author":"M.L.N.G. Malbrain","year":"2020","journal-title":"Ann. Intensive Care"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0290451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T05:32:52Z","timestamp":1703050372000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0290451"}},"subtitle":[],"editor":[{"given":"Nata\u0161a","family":"Kova\u010d","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":59,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0290451","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,28]]}}}