{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:48:04Z","timestamp":1787060884526,"version":"build-2736575974"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood drawings is a common hospital procedure involving laboratory and clinical disciplines that is important for the diagnosis and management of illnesses in children. Blood drawings with pre-analytical error (PAE) can lead to increased costs for hospitals and healthcare organisations. The direct cost of blood drawings after a PAE is not fully understood in paediatric hospital care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to estimate the average direct cost of PAE per year and per 10,000 blood drawings in tertiary paediatric care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cost analysis using a bottom-up approach was conducted on the basis of combined information from the hospital\u2019s laboratory register for the period 2013\u20132014 and clinical in-ward observations at a tertiary children\u2019s referral hospital in Sweden, the Astrid Lindgren Children\u2019s Hospital. For the analysis, we hypothesised the re-collection of all blood drawings with PAE and included the average costs of the sampling materials, the time of the healthcare personnel, the laboratory analyses, and in-ward premises based on the time spent on the blood sampling procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The annual cost of PAE was estimated to be 74,267 euros per 54,040 blood drawings, which corresponds to 13,756 euros per 10,000 blood drawings or 1.5 euros per draw. The personnel cost represented 60.1% (45,261 euros per year) of the cost due to PAE, followed by costs for hospitalisation (25.2%), laboratory analyses (8.1%), and materials (5.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PAEs lead to substantial increases in the costs in tertiary paediatric hospital care. If these PAEs can be avoided, costs related to the re-collection of blood drawings with PAE may be re-allocated to other health-promoting activities for children visiting hospital institutions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0290636","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T13:21:45Z","timestamp":1692969705000},"page":"e0290636","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Direct costs of blood drawings with pre-analytical errors in tertiary paediatric hospital care"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6168-2215","authenticated-orcid":true,"given":"Henrik","family":"Hjelmgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelie","family":"Heintz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt-Marie","family":"Ygge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Nordlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"issue":"1","key":"pone.0290636.ref001","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1515\/cclm-2017-0853","article-title":"Role of laboratory medicine in collaborative healthcare","volume":"57","author":"ID Watson","year":"2018","journal-title":"Clin Chem Lab Med"},{"issue":"8","key":"pone.0290636.ref002","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.5858\/arpa.2013-0331-CP","article-title":"Clinical consequences of specimen rejection a College of American Pathologists Q-Probes analysis of 78 clinical laboratories","volume":"138","author":"DS Karcher","year":"2014","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"pone.0290636.ref003","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1515\/CCLM.2006.073","article-title":"Preanalytical variability: the dark side of the moon in laboratory testing","volume":"44","author":"G Lippi","year":"2006","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"pone.0290636.ref004","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1515\/dx-2018-0018","article-title":"Blood sample quality","volume":"6","author":"G Lippi","year":"2019","journal-title":"Diagnosis"},{"issue":"6","key":"pone.0290636.ref005","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1515\/cclm-2014-1124","article-title":"Performance criteria and quality indicators for the pre-analytical phase","volume":"53","author":"M Plebani","year":"2015","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"pone.0290636.ref006","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cca.2009.03.024","article-title":"Pre-analytical workstations: a tool for reducing laboratory errors","volume":"404","author":"G. 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