{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:14:23Z","timestamp":1784265263485,"version":"3.55.0"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Acne vulgaris affects a significant number of females into adulthood. Juvenile acne and adult acne have different presentations and potentially distinctive pathogeneses. However, patterns in treatments specifically related to the adult female population have previously not been studied.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Retrospective database analysis of healthcare utilization and medications prescribed for acne using the National Ambulatory Medical Care Survey (NAMCS) data from 2002\u20132016 was performed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>After age 20, acne accounted for an almost 2.5-fold higher proportion of dermatology visits among females compared to males (10.1% vs. 4.1%, P &lt; 0.001). Tetracycline-class antibiotics were the most prescribed therapy within all age groups of females between 2002\u20132016. However, there was also a substantial rise in prescriptions of spironolactone beginning in 2012.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>A significantly greater proportion of dermatology visits by adult females are for acne in comparison to adult males. Tetracycline-class antibiotics remain the most prescribed therapy in adult age groups despite a potentially different pathogenesis of adult acne. Therefore, there is a need for further studies comparing the effectiveness of therapies specifically for adult female acne.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0290763","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T17:47:30Z","timestamp":1695318450000},"page":"e0290763","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Acne accounts for an almost 2.5-fold higher proportion of dermatology visits among adult females compared to adult males in the United States: A study of the national ambulatory medical care survey from 2002\u20132016"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-6929","authenticated-orcid":true,"given":"Jungsoo","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Nock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-8308","authenticated-orcid":true,"given":"Christopher G.","family":"Bunick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"issue":"1","key":"pone.0290763.ref001","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jaad.2007.06.045","article-title":"The prevalence of acne in adults 20 years and older","volume":"58","author":"C.N. Collier","year":"2008","journal-title":"J Am Acad Dermatol"},{"issue":"9","key":"pone.0290763.ref002","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1001\/jamadermatol.2021.2185","article-title":"Patient Perspectives on the Lived Experience of Acne and Its Treatment Among Adult Women With Acne: A Qualitative Study","volume":"157","author":"J.S. Barbieri","year":"2021","journal-title":"JAMA Dermatol"},{"issue":"4","key":"pone.0290763.ref003","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/1203475415573775","article-title":"Trends in Ambulatory Health Care Usage for Adult Acne","volume":"19","author":"S.A. Davis","year":"2015","journal-title":"J Cutan Med Surg"},{"issue":"2","key":"pone.0290763.ref004","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijwd.2017.10.006","article-title":"A review of diagnosis and treatment of acne in adult female patients","volume":"4","author":"A.U. 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Zaenglein","year":"2016","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"pone.0290763.ref023","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jaad.2020.06.044","article-title":"Comparative analysis of prescribing patterns of tetracycline class antibiotics and spironolactone between advanced practice providers and physicians in the treatment of acne vulgaris","volume":"84","author":"A.K. Guzman","year":"2021","journal-title":"J Am Acad Dermatol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0290763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T17:47:57Z","timestamp":1695318477000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0290763"}},"subtitle":[],"editor":[{"given":"Nourtan F.","family":"Abdeltawab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":23,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0290763","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]}}}