{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:25:52Z","timestamp":1774459552869,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Academic Schools of Traditional Chinese Medicine","award":["XSLP-2013-35"],"award-info":[{"award-number":["XSLP-2013-35"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To systematically evaluate the efficacy and safety of Sodium tanshinone \u2161A sulfonate injection (STS) in the treatment of unstable angina pectoris (UAP).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, Web of Science, Embase were searched by computer. The research covers the clinical randomized controlled trials of STS in the treatment of unstable angina pectoris published from the establishment of the library to January 31, 2023. Two researchers independently screened the literature, extracted data and evaluated the risk of research bias, and then conducted meta-analysis with RevMan5.3 software.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 37 randomized controlled trials were included, involving 3926 patients in total. Meta analysis results showed that, compared with conventional western medicine alone, STS combined with conventional western medicine could reduce the frequency (SMD = -2.61, 95%CI[-4.27, -0.96], <jats:italic>P<\/jats:italic> = 0.002) and duration (SMD = -4.01, 95%CI[-6.18, -1.84], <jats:italic>P<\/jats:italic> = 0.0003) of angina pectoris, improve ECG efficacy (OR = 3.61, 95%CI[2.79, 4.68], <jats:italic>P&lt;<\/jats:italic>0.00001) and clinical symptom efficacy (OR = 4.02, 95%CI[3.32, 4.87], <jats:italic>P&lt;<\/jats:italic>0.00001), reduce TG(SMD = -0.60, 95%CI[-1.04, -0.16], <jats:italic>P<\/jats:italic> = 0.008), TC(SMD = -3.86, 95%CI[-6.37, -1.34], <jats:italic>P<\/jats:italic> = 0.003), and LDL-C(SMD = -1.54, 95%CI[-2.67, -0.42], <jats:italic>P<\/jats:italic> = 0.007), decrease plasma viscosity(SMD = -1.02, 95%CI[-1.58, -0.47], <jats:italic>P&lt;<\/jats:italic>0.0003), whole blood low shear viscosity(SMD = -0.85, 95%CI[-1.21, -0.49], <jats:italic>P&lt;<\/jats:italic>0.00001), whole blood high shear viscosity(SMD = -0.82, 95%CI[-1.44, -0.20], <jats:italic>P<\/jats:italic> = 0.009), and erythrocyte aggregation index(SMD = -1.00, 95%CI[-1.75, -0.25], <jats:italic>P<\/jats:italic> = 0.009), and bring down CRP(SMD = -1.39, 95%CI[-1.91, -0.86], <jats:italic>P<\/jats:italic>&lt;0.00001). The incidence of adverse reactions in the treatment group was higher than that in the control group (OR = 2.26, 95%CI[1.06, 4.85], <jats:italic>P<\/jats:italic> = 0.04). Neither of the two groups suffered from abnormal liver and kidney function during the study process.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>STS combined with routine treatment has a definite clinical efficacy and certain safety in the treatment of UAP, but it needs to be further confirmed by high-quality and low-bias randomized controlled trials in the future.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0290841","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T17:34:40Z","timestamp":1693503280000},"page":"e0290841","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["The efficacy and safety of sodium tanshinone \u2161A sulfonate injection in the treatment of unstable angina pectoris: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6855-1800","authenticated-orcid":true,"given":"Xiaoqi","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maoxia","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sining","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6228-0349","authenticated-orcid":true,"given":"Dong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"issue":"2","key":"pone.0290841.ref001","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0254-6272(16)30020-6","article-title":"Danshenchuanxiongqin injection in the treatment of unstable angina pectoris: a systematic review and Meta-analysis[J]","volume":"36","author":"X Zhang","year":"2016","journal-title":"J Tradit Chin Med"},{"issue":"2","key":"pone.0290841.ref002","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1056\/NEJM200001133420207","article-title":"Unstable angina pectoris[J]","volume":"342","author":"Y Yeghiazarians","year":"2000","journal-title":"N Engl J Med"},{"issue":"3","key":"pone.0290841.ref003","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ajem.2016.12.070","article-title":"Anticoagulants in ischemia-guided management of non-ST-elevation acute coronary syndromes[J]","volume":"35","author":"M. 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