{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T19:06:15Z","timestamp":1784315175049,"version":"3.55.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Science and Technological Development of Republic of Serbia","award":["451-03-68"],"award-info":[{"award-number":["451-03-68"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The present systematic review and meta-analysis aimed to evaluate the periodontal health of systemic sclerosis patients compared with non-systemic sclerosis controls.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>Online databases were searched for eligible studies on February 24, 2023. The primary outcomes of interest in systemic sclerosis patients and controls included the clinical attachment level, periodontal probing depth, recession depth, plaque index, bleeding on probing score, gingival index, number of teeth with periodontitis, prevalence of periodontitis and gingivitis, and extent and severity of periodontitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Fourteen studies met inclusion criteria and were incorporated in the qualitative and quantitative analysis. In comparison with the controls, systemic sclerosis patients had a higher prevalence of periodontitis (OR = 7.63 (1.74\u201333.50), p = 0.04, I<jats:sup>2<\/jats:sup> = 69%), including more severe forms of periodontitis (OR = 6.68 (3.39\u201313.15), p = 0.85, I<jats:sup>2<\/jats:sup> = 0%), as well as higher periodontal probing depth ((0.88 (0.45\u20131.31), p = 0.02, I<jats:sup>2<\/jats:sup> = 99%)), clinical attachment level (1.22 (0.8\u20131.64), p = 0.003, I<jats:sup>2<\/jats:sup> = 98%), and plaque presence (0.83 (0.13\u20131.53), p = 0.03, I<jats:sup>2<\/jats:sup> = 96%). There was no statistically significant difference in gingival inflammation (1.14 (0.07\u20132.21), p = 0.04, I<jats:sup>2<\/jats:sup> = 98%).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The systematic review and the meta-analysis showed that systemic sclerosis patients suffer from worse periodontal health than non-systemic sclerosis individuals.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0291078","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T18:24:00Z","timestamp":1706898240000},"page":"e0291078","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Periodontal health status in systemic sclerosis patients: Systematic review and meta-analysis"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-7088","authenticated-orcid":true,"given":"Stefan","family":"Sredojevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejana","family":"Colak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3765-7378","authenticated-orcid":true,"given":"Rok","family":"Gaspersic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavica","family":"Pavlov Dolijanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-4934","authenticated-orcid":true,"given":"Aleksandar","family":"Jakovljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"Nikolic-Jakoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"pone.0291078.ref001","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.autrev.2015.07.012","article-title":"Quality of life in systemic sclerosis","volume":"14","author":"C Almeida","year":"2015","journal-title":"Autoimmun Rev"},{"key":"pone.0291078.ref002","doi-asserted-by":"crossref","first-page":"A311","DOI":"10.1016\/j.autrev.2009.11.003","article-title":"Geoepidemiology of systemic sclerosis.","volume":"9","author":"B Ranque","year":"2010","journal-title":"Autoimmun Rev"},{"key":"pone.0291078.ref003","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/qjmed\/hcp174","article-title":"Improved survival in systemic sclerosis is associated with better ascertainment of internal organ disease: a retrospective cohort study","volume":"103","author":"SI Nihtyanova","year":"2010","journal-title":"QJM"},{"key":"pone.0291078.ref004","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.berh.2012.01.011","article-title":"Scleroderma\u2013New aspects in pathogenesis and treatment.","volume":"26","author":"A Balbir-Gurman","year":"2012","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"6","key":"pone.0291078.ref005","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/ard.2008.091710","article-title":"Systemic sclerosis and its pulmonary complications in The Netherlands: An epidemiological study","volume":"68","author":"M. 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