{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:46:20Z","timestamp":1793321180054,"version":"4.5.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Excision of intracranial meningioma has been associated with major intraoperative blood loss (IBL). The objective of the study was to identify factors affecting IBL during removal of meningioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively studied medical records of 530 adult patients who underwent surgery for intracranial meningioma at Sichuan Provincial People\u2019s Hospital between September 2018 and May 2022. We obtained the following data from each patient\u2019s medical chart: age, sex, height, weight, comorbidities, blood pressure, history of smoking and alcohol, imaging examination findings, pathologic diagnosis, albumin, creatinine, calcium, magnesium, hemoglobin (Hb), hematocrit, platelet count, activated partial thromboplastin time, international normalized ratio, fibrinogen concentration and blood transfusion. Univariate and multivariate analyses were performed to identify risk factors for greater IBL during removal of intracranial meningioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 530 patients were included in our study. Univariate analysis revealed that sex (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004), two-dimensional (2D) tumor area (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), sinus involvement (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.014), World Health Organization grade (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.015), preoperative albumin level (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.032), preoperative Hb level (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001) and preoperative platelet count (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) were significantly associated with greater IBL. Multivariate analysis revealed that greater 2D tumor area (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), higher preoperative albumin concentration (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.029) and higher preoperative platelet count (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03) were independent risk factors for greater IBL in resection of intracranial meningioma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Larger tumor size, higher preoperative albumin concentration and higher preoperative platelet count were identified as independent risk factors for greater IBL in resection of intracranial meningioma.<\/jats:p>\n                  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