{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:50:08Z","timestamp":1791607808627,"version":"4.3.4"},"reference-count":18,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Micropulse cyclophotocoagulation (MPCPC) has been shown in adults to offer a favorable post-operative safety profile compared to continuous wave transscleral cyclophotocoagulation (CWCPC) in the management of glaucoma. The purpose of this study is to evaluate the long term efficacy, safety, and effectiveness of MPCPC in the management of pediatric glaucoma when compared to CWCPC.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>IRB approved retrospective chart review of patients with pediatric glaucoma that underwent MPCPC and CWCPC at 2 separate institutions. Success was defined as intraocular pressure (IOP) between 5 and 21mmHg on any number of topical glaucoma medication without requiring additional surgical intervention or oral IOP lowering medication.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Of the 48 patients in the study, 22 (26 eyes) underwent MPCPC and 26 (30 eyes) underwent CWCPC. At 1 year, 7 out of 26 eyes (26.9%) achieved success in the MPCPC group compared to 13 out of 30 eyes (43.3%) in the CWCPC group. Survival analysis unveiled a statistically significant difference in success between the two groups (p = 0.03).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In pediatric glaucoma patients undergoing cyclophotocoagulation procedures, CWCPC outperformed MPCPC using default settings in terms of achieving long-term IOP control. Additional studies are required to evaluated augmented MPCPC settings in pediatric glaucoma patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0291247","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T18:59:15Z","timestamp":1704221955000},"page":"e0291247","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Micropulse cyclophotocoagulation compared to continuous wave cyclophotocoagulation for the management of refractory pediatric glaucoma"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4785-3361","authenticated-orcid":true,"given":"Bo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Musser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"Chaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney L.","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"issue":"3","key":"pone.0291247.ref001","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1442-9071.2006.01415.x","article-title":"Comparison of acute structural and histopathological changes of the porcine ciliary processes after endoscopic cyclophotocoagulation and transscleral cyclophotocoagulation","volume":"35","author":"M. B. Pantcheva","year":"2007","journal-title":"Clin. Experiment. Ophthalmol."},{"issue":"8","key":"pone.0291247.ref002","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0161-6420(96)30508-3","article-title":"Long-term Outcome of Initial Ciliary Ablation with Contact Diode Laser Transscleral Cyclophotocoagulation for Severe Glaucoma","volume":"103","author":"O. Kosoko","year":"1996","journal-title":"Ophthalmology"},{"issue":"8","key":"pone.0291247.ref003","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/IJG.0000000000000715","article-title":"Micropulse Cyclophotocoagulation: Initial Results in Refractory Glaucoma","volume":"26","author":"M. E. Emanuel","year":"2017","journal-title":"J. Glaucoma"},{"issue":"1","key":"pone.0291247.ref004","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/ceo.12360","article-title":"Micropulse versus continuous wave transscleral diode cyclophotocoagulation in refractory glaucoma: a randomized exploratory study","volume":"43","author":"M. C. D. Aquino","year":"2015","journal-title":"Clin. Experiment. Ophthalmol."},{"issue":"3","key":"pone.0291247.ref005","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1442-9071.2010.02238.x","article-title":"Micropulse transscleral diode laser cyclophotocoagulation in the treatment of refractory glaucoma","volume":"38","author":"A. M. Tan","year":"2010","journal-title":"Clin. Experiment. Ophthalmol."},{"issue":"4","key":"pone.0291247.ref006","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.survophthal.2019.01.001","article-title":"Micropulse laser for the treatment of glaucoma: A literature review","volume":"64","author":"A. Ma","year":"2019","journal-title":"Surv. Ophthalmol."},{"key":"pone.0291247.ref007","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.2147\/OPTH.S226554","article-title":"Outcome Of MicroPulse\u00ae Transscleral Photocoagulation In Different Types Of Glaucoma","volume":"13","author":"A. Al Habash","year":"2019","journal-title":"Clin. Ophthalmol. Auckl. NZ"},{"issue":"9","key":"pone.0291247.ref008","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1097\/IJG.0000000000001552","article-title":"Micropulse Trans-scleral Cyclophotocoagulation in Patients With Glaucoma: 1- and 2-Year Treatment Outcomes","volume":"29","author":"R. M. P. C. de Crom","year":"2020","journal-title":"J. Glaucoma"},{"issue":"4","key":"pone.0291247.ref009","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1177\/1120672119839303","article-title":"Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma","volume":"30","author":"A. T. Nguyen","year":"2020","journal-title":"Eur. J. Ophthalmol."},{"issue":"12","key":"pone.0291247.ref010","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1097\/IJG.0000000000001644","article-title":"Micropulse Cyclophotocoagulation: A Multicenter Study of Efficacy, Safety, and Factors Associated With Increased Risk of Complications","volume":"29","author":"S. Radhakrishnan","year":"2020","journal-title":"J. Glaucoma"},{"issue":"6","key":"pone.0291247.ref011","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jcjo.2021.01.015","article-title":"Micropulse trans-scleral laser therapy outcomes for uncontrolled glaucoma: a prospective 18-month study","volume":"56","author":"M. Marchand","year":"2021","journal-title":"Can. J. Ophthalmol."},{"issue":"3","key":"pone.0291247.ref012","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ogla.2019.02.002","article-title":"Micropulse Transscleral Cyclophotocoagulation: A Look at Long-Term Effectiveness and Outcomes","volume":"2","author":"S. Sarrafpour","year":"2019","journal-title":"Ophthalmol. Glaucoma"},{"issue":"3","key":"pone.0291247.ref013","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ogla.2020.04.004","article-title":"The Need for Rigor in Evaluating Micropulse and Other New Procedures","volume":"3","author":"H. A. Quigley","year":"2020","journal-title":"Ophthalmol. Glaucoma"},{"issue":"10","key":"pone.0291247.ref014","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1097\/IJG.0000000000000757","article-title":"Outcome of Micropulse Laser Transscleral Cyclophotocoagulation on Pediatric Versus Adult Glaucoma Patients","volume":"26","author":"J. H. Lee","year":"2017","journal-title":"J. Glaucoma"},{"key":"pone.0291247.ref015","first-page":"1120672119858226","article-title":"Micropulsed diode laser cyclophotocoagulation in recurrent pediatric glaucoma","author":"E. M. Elhefney","year":"2019","journal-title":"Eur. J. Ophthalmol."},{"issue":"10","key":"pone.0291247.ref016","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/IJG.0000000000001053","article-title":"Micropulse Versus Continuous Wave Transscleral Cyclophotocoagulation in Refractory Pediatric Glaucoma","volume":"27","author":"A. M. Abdelrahman","year":"2018","journal-title":"J. Glaucoma"},{"key":"pone.0291247.ref017","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.2147\/OPTH.S365647","article-title":"Evidence-Based Consensus Guidelines Series for MicroPulse Transscleral Laser Therapy: Dosimetry and Patient Selection","volume":"16","author":"T. M. Grippo","year":"2022","journal-title":"Clin. Ophthalmol. Auckl. NZ"},{"issue":"5","key":"pone.0291247.ref018","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s00417-021-05436-1","article-title":"Outcomes of a combination of augmented MicroPulse and limited Continuous Wave Cyclophotocoagulation in patients with refractory glaucoma","volume":"260","author":"S. Gupta","year":"2022","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0291247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T18:59:33Z","timestamp":1704221973000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0291247"}},"subtitle":[],"editor":[{"given":"Nader Hussien Lotfy","family":"Bayoumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1,2]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0291247","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,2]]}}}