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More than half (23\/40) of the participating TB laboratories reported having performed COVID-19 diagnostics in the early phase of the pandemic, in part with negative impact on the mycobacterial service activities. All participating laboratories reported shortages of consumables and laboratory equipment due to supply chain issues. Average monthly sample numbers decreased by 24% between January 2020 and October 2020 compared to pre-pandemic averages. At the end of the study period, most participating laboratories had not returned to pre-pandemic average MTBC PCR throughput.<\/jats:p>","DOI":"10.1371\/journal.pone.0291404","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T18:00:28Z","timestamp":1713290428000},"page":"e0291404","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of the COVID-19 pandemic on the real-world diagnostic infrastructure for tuberculosis\u2014An ESGMYC collaborative study"],"prefix":"10.1371","volume":"19","author":[{"given":"Laura","family":"Paulowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Filip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateja","family":"Jankovic Makek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Guglielmetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-4376","authenticated-orcid":true,"given":"Delia","family":"Goletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakko","family":"van Ingen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Kranzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8353-5964","authenticated-orcid":true,"given":"Florian P.","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of ESGMYC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"issue":"6","key":"pone.0291404.ref001","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/s41591-022-01750-1","article-title":"COVID-19 and resilience of healthcare systems in ten countries","volume":"28","author":"C Arsenault","year":"2022","journal-title":"Nat Med"},{"key":"pone.0291404.ref002","volume-title":"Global tuberculosis report 2021.","author":"World Health Organization","year":"2021"},{"key":"pone.0291404.ref003","unstructured":"World Health Organization. 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