{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:09:59Z","timestamp":1792289399540,"version":"4.4.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Nearly 23 million adults ages 50\u201375 are overdue for colorectal cancer (CRC) screening. In March 2020, the Centers for Medicare &amp; Medicaid issued guidance that all non-urgent procedures be delayed due to the COVID-19 pandemic. Screening delays may have effects on the presentation of rectal cancer and the natural history of the disease. The aim of this study was to determine if procedural suspension due to the COVID-19 pandemic was associated with an increased proportion of acute presentations or more advanced stage at diagnosis for patients with rectal cancer. We conducted a single-center, retrospective review of adult patients with new or recurrent rectal adenocarcinoma from 2016\u20132021. We compared patients presenting before (pre-COVID) to those diagnosed after (COVID) March 1, 2020. Of 208 patients diagnosed with rectal cancer, 163 were diagnosed pre-COVID and 45 patients in the COVID group. Cohorts did not differ among age, sex, race, insurance status, marital status, rurality, or BMI. There was no difference in stage at presentation with the majority diagnosed with stage III disease (40.0% vs 33.3%, p = 0.26). Similar proportions of patients presented acutely (67.5% vs 64.4%, p = 0.71). Presenting symptoms were also similar between cohorts. On adjusted analysis, male sex, white race, and uninsured status were found to have significant impact acuity of presentation, while diagnosis before or after the onset of the pandemic remained non-significant (OR 1.25, 95% CI0.57\u20132.72; p = 0.59). While screening rates have decreased during the COVID pandemic, patients with rectal cancer did not appear to have an increased level of acuity or stage at presentation. These findings could result from the indolent nature of the disease and may change as the pandemic progresses.<\/jats:p>","DOI":"10.1371\/journal.pone.0291447","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:38:33Z","timestamp":1694713113000},"page":"e0291447","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rectal cancer presentation during the COVID-19 pandemic: Are decreasing screening rates leading to an increase in acute presentations?"],"prefix":"10.1371","volume":"18","author":[{"given":"Tia S.","family":"Sutton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scarlett","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimei","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Lisa","family":"Ciarrocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-2094","authenticated-orcid":true,"given":"Michael D.","family":"Honaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"issue":"3","key":"pone.0291447.ref001","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3322\/caac.21601","article-title":"Colorectal cancer statistics, 2020.","volume":"70","author":"RL Siegel","year":"2020","journal-title":"CA Cancer J Clin."},{"issue":"2","key":"pone.0291447.ref002","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/gutjnl-2016-312712","article-title":"Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study","volume":"67","author":"CA Doubeni","year":"2018","journal-title":"Gut"},{"key":"pone.0291447.ref003","doi-asserted-by":"crossref","first-page":"100458","DOI":"10.1016\/j.lanepe.2022.100458","article-title":"Overall and stage-specific survival of patients with screen-detected colorectal cancer in european countries: A population-based study in 9 countries.","volume":"21","author":"R Cardoso","year":"2022","journal-title":"Lancet Reg Health Eur."},{"issue":"12","key":"pone.0291447.ref004","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1056\/NEJMoa1301969","article-title":"Long-term colorectal-cancer incidence and mortality after lower endoscopy","volume":"369","author":"R Nishihara","year":"2013","journal-title":"N Engl J Med"},{"issue":"5","key":"pone.0291447.ref005","doi-asserted-by":"crossref","first-page":"e200588","DOI":"10.1001\/jamahealthforum.2020.0588","article-title":"Colorectal Cancer Screening and Prevention in the COVID-19 Era.","volume":"1","author":"RB Issaka","year":"2020","journal-title":"JAMA Health Forum."},{"key":"pone.0291447.ref006","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1200\/EDBK_279901","article-title":"Colorectal Cancer in the Young: Epidemiology, Prevention, Management.","volume":"40","author":"RL Siegel","year":"2020","journal-title":"American Society of Clinical Oncology Educational Book."},{"key":"pone.0291447.ref007","year":"2020","journal-title":"CMS Releases Recommendations on Adult Elective Surgeries, Non-Essential Medical, Surgical, and Dental Procedures During COVID-19 Response. 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