{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:53:39Z","timestamp":1784055219507,"version":"3.55.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health and Welfare (MOHW) and Korea Health Industry Development Institute","award":["Supporting Project to evaluate New Domestic Medical Devices in Hospitals"],"award-info":[{"award-number":["Supporting Project to evaluate New Domestic Medical Devices in Hospitals"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This study aimed to assess the performance of a tongue-positioning device in interfractional tongue position reproducibility by cone-beam computed tomography (CBCT). Fifty-two patients treated with radiation therapy (RT) while using a tongue positioning device were included in the study. All patients were treated with 28 or 30 fractions using the volumetric modulated arc therapy technique. CBCT images were acquired at the 1<jats:sup>st<\/jats:sup>, 7<jats:sup>th<\/jats:sup>, 11<jats:sup>th<\/jats:sup>, 15<jats:sup>th<\/jats:sup>, 19<jats:sup>th<\/jats:sup>, 23<jats:sup>th<\/jats:sup>, and 27<jats:sup>th<\/jats:sup> fractions. Tongues on planning computed tomography (pCT) and CBCT images were contoured in the treatment planning system. Geometric differences in the tongue between pCT and CBCT were assessed by the Dice similarity coefficient (DSC) and averaged Hausdorff distance (AHD). Two-dimensional <jats:italic>in vivo<\/jats:italic> measurements using radiochromic films were performed in 13 patients once a week during sessions. The planned dose distributions were compared with the measured dose distributions using gamma analysis with criteria of 3%\/3 mm. In all patients, the mean DSC at the 1<jats:sup>st<\/jats:sup> fraction (pCT versus 1<jats:sup>st<\/jats:sup> CBCT) was 0.80 while the mean DSC at the 27<jats:sup>th<\/jats:sup> fraction (pCT versus 27<jats:sup>th<\/jats:sup> CBCT) was 0.77 with statistical significance (<jats:italic>p<\/jats:italic>-value = 0.015). There was no statistically significant difference in DSC between the 1<jats:sup>st<\/jats:sup> fraction and any other fraction, except for the 27<jats:sup>th<\/jats:sup> fraction. There was statistically significant difference in AHD between the 1<jats:sup>st<\/jats:sup> fraction and the 19<jats:sup>th<\/jats:sup>, 23<jats:sup>th<\/jats:sup>, and 27<jats:sup>th<\/jats:sup> fractions (<jats:italic>p<\/jats:italic>-value &lt; 0.05). <jats:italic>In vivo<\/jats:italic> measurements showed an average gamma passing rate of 90.54%. There was no significant difference between measurements at the 1<jats:sup>st<\/jats:sup> week and those at other weeks. The tongue geometry during RT was compared between pCT and CBCT. In conclusion, the novel tongue-positioning device was found to minimize interfractional variations in position and shape of the tongue.<\/jats:p>","DOI":"10.1371\/journal.pone.0291712","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T17:31:55Z","timestamp":1695317515000},"page":"e0291712","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Novel tongue-positioning device to reduce tongue motions during radiation therapy for head and neck cancer: Geometric and dosimetric evaluation"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9483-158X","authenticated-orcid":true,"given":"Seongmoon","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bitbyeol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung 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