{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:37:27Z","timestamp":1792791447507,"version":"4.5.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Elanco Animal Health Ltd"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Osteoarthritis is the most common joint disease in companion animals. Several client-report outcome measures (CROMs) have been developed and validated to monitor patients and their response to treatment. However, estimates for minimal clinically-important differences for these CROMs in the context of osteoarthritis have not been published.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Data from the Cl\u00ednica Veterin\u00e1ria de C\u00e3es (Portuguese Gendarmerie Canine Clinic) clinical records were extracted. Baseline and 30-day post-treatment follow-up data from 296 dogs treated for hip osteoarthritis were categorized based on an anchor question, and estimates of minimal clinically-important differences (MCIDs) using distribution-based and anchor-based methods were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For the LOAD, the anchor-based methods provided a MCID estimate range of -2.5 to -9.1 and the distribution-based methods from 1.6 to 4.2. For the COI, the anchor-based methods provided a MCID estimate range of -4.5 to -16.6 and the distribution-based methods from 2.3 to 2.4. For the dimensions of COI, values varied from -0.5 to -4.9 with the anchor-based methods and from 0.6 to 2.7 with the distribution-based methods. Receiver operator characteristic curves provided areas under the curve &gt;0.7 for the COI, indicating an acceptable cut-off point, and &gt;0.8 for the LOAD, indicating an excellent cut-off point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our estimates of MCIDs for dogs with OA were consistent with previously proposed values of -4 for the LOAD and -14 for the COI in a post-surgical intervention context. ROC curve data suggest that LOAD may more reliably differentiate between anchor groups. We also presented estimates from COI of -4 for Stiffness, Function, and Gait and -3 for quality of life. These estimates can be used for research and patient monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0291881","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T13:34:00Z","timestamp":1695216840000},"page":"e0291881","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Minimal clinically-important differences for the \u201cLiverpool Osteoarthritis in Dogs\u201d (LOAD) and the \u201cCanine Orthopedic Index\u201d (COI) in dogs with osteoarthritis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-3709","authenticated-orcid":true,"given":"J. C.","family":"Alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Innes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"pone.0291881.ref001","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.00220","article-title":"Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review.","volume":"7","author":"KL Anderson","year":"2020","journal-title":"Front Vet Sci."},{"key":"pone.0291881.ref002","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1186\/s12917-020-02647-2","article-title":"Clinical and diagnostic imaging findings in police working dogs referred for hip osteoarthritis","volume":"16","author":"JC Alves","year":"2020","journal-title":"BMC Vet Res"},{"key":"pone.0291881.ref003","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1038\/s41598-018-23940-z","article-title":"Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care.","volume":"8","author":"KL Anderson","year":"2018","journal-title":"Sci Rep."},{"key":"pone.0291881.ref004","doi-asserted-by":"crossref","first-page":"100655","DOI":"10.1016\/j.tcam.2022.100655","article-title":"Characterization of Weight-bearing Compensation in Dogs With Bilateral Hip Osteoarthritis.","volume":"49","author":"JC Alves","year":"2022","journal-title":"Top Companion Anim Med."},{"key":"pone.0291881.ref005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-0038-1667063","article-title":"Sensitivity and specificity of a weight distribution platform for the detection of objective lameness and orthopaedic disease.","volume":"31","author":"W Clough","year":"2018","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0291881.ref006","article-title":"Spontaneous dog osteoarthritis\u2014a One Medicine vision.","author":"RL Meeson","year":"2019","journal-title":"Nat Rev Rheumatol."},{"key":"pone.0291881.ref007","doi-asserted-by":"crossref","first-page":"e0131839","DOI":"10.1371\/journal.pone.0131839","article-title":"Criterion Validation Testing of Clinical Metrology Instruments for Measuring Degenerative Joint Disease Associated Mobility Impairment in Cats.","volume":"10","author":"ME Gruen","year":"2015","journal-title":"PLoS One."},{"key":"pone.0291881.ref008","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tvjl.2018.04.013","article-title":"Measuring pain in dogs and cats using structured behavioural observation","volume":"236","author":"J Reid","year":"2018","journal-title":"Vet J"},{"key":"pone.0291881.ref009","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12917-022-03221-8","article-title":"A survey on the orthopedic and functional assessment in a Portuguese population of police working dogs","volume":"18","author":"JCA Alves","year":"2022","journal-title":"BMC Vet Res"},{"key":"pone.0291881.ref010","doi-asserted-by":"crossref","first-page":"20150883","DOI":"10.1098\/rsbl.2015.0883","article-title":"Dogs recognize dog and human emotions.","volume":"12","author":"N Albuquerque","year":"2016","journal-title":"Biol Lett"},{"key":"pone.0291881.ref011","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2460\/ajvr.2004.65.1077","article-title":"Development of a questionnaire to measure the effects of chronic pain on health-related quality of life in dogs","volume":"65","author":"ML Wiseman-Orr","year":"2004","journal-title":"Am J Vet Res"},{"key":"pone.0291881.ref012","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/inp.k647","article-title":"\u2018How do I know my animal got better?\u2019\u2013measuring outcomes in small animal orthopaedics.","volume":"40","author":"B Walton","year":"2018","journal-title":"In Pract"},{"key":"pone.0291881.ref013","doi-asserted-by":"crossref","first-page":"e58125","DOI":"10.1371\/journal.pone.0058125","article-title":"Evaluation of construct and criterion validity for the \u2018Liverpool Osteoarthritis in Dogs\u2019 (LOAD) clinical metrology instrument and comparison to two other instruments.","volume":"8","author":"MB Walton","year":"2013","journal-title":"PLoS One."},{"key":"pone.0291881.ref014","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1532-950X.2014.12141.x","article-title":"The Canine Orthopedic Index. 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A systematic review of trials randomizing patients to blind and nonblind sub-studies","volume":"43","author":"A Hr\u00f3bjartsson","year":"2014","journal-title":"Int J Epidemiol."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0291881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T09:51:35Z","timestamp":1730109095000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0291881"}},"subtitle":[],"editor":[{"given":"Wenguo","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0291881","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]}}}