{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:30:53Z","timestamp":1783571453970,"version":"3.55.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"crossref","award":["17\/0005712; ISRCTN number 90795724"],"award-info":[{"award-number":["17\/0005712; ISRCTN number 90795724"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EFSD Novo Nordisk Foundation","award":["NNF19SA058974"],"award-info":[{"award-number":["NNF19SA058974"]}]},{"DOI":"10.13039\/100015769","name":"Dexcom","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Undiagnosed diabetes in pregnancy is associated with stillbirth and perinatal complications, but standard testing for gestational diabetes using the oral glucose tolerance test (OGTT) is impractical and exacerbates healthcare inequalities. There is an urgent need to improve the accuracy, acceptability and accessibility of glucose testing in pregnancy. We qualitatively assessed the feasibility and acceptability of two alternative home-based methods of glucose testing in pregnant women, using continuous glucose monitoring (CGM), with or without a home-based OGTT.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We recruited women with a singleton pregnancy at 28 weeks\u2019 gestation with \u22651 risk factor for gestational diabetes attending antenatal glucose testing. A Dexcom G6 CGM device was sited and women were asked to take a 75g OGTT solution (Rapilose) on day 4 after an overnight fast. Qualitative interviews were performed with 20 participants using video conferencing according to a semi-structured interview schedule and thematically analysed using NVIVO software.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>92 women were recruited; 73 also underwent a home OGTT. Women had an average of 6.9 days of glucose monitoring and found the CGM painless, easy to use with few or no adverse events. During the qualitative study, the main themes identified were reassurance and convenience. All women interviewed would recommend CGM and a home OGTT for diagnosis of gestational diabetes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>CGM with or without a home OGTT is feasible and acceptable to pregnant women for diagnosis of gestational diabetes and offered advantages of convenience and reassurance. Further work is needed to clarify diagnostic thresholds for gestational diabetes using CGM metrics.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0292094","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T17:30:27Z","timestamp":1695835827000},"page":"e0292094","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Feasibility and acceptability of continuous glucose monitoring in pregnancy for the diagnosis of gestational diabetes: A single-centre prospective mixed methods study"],"prefix":"10.1371","volume":"18","author":[{"given":"Laura C.","family":"Kusinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-8329","authenticated-orcid":true,"given":"Claire L.","family":"Meek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"pone.0292094.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabres.2018.02.031","article-title":"FIGO-IDF joint statement and declaration on hyperglycemia in pregnancy","volume":"145","author":"S Sadikot","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"pone.0292094.ref002","author":"Organisation WH","year":"2013","journal-title":"Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy"},{"issue":"8","key":"pone.0292094.ref003","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/1471-0528.15659","article-title":"Gestational diabetes and the risk of late stillbirth: a case-control study from England, UK","volume":"126","author":"T Stacey","year":"2019","journal-title":"Bjog"},{"issue":"3","key":"pone.0292094.ref004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11892-015-0580-y","article-title":"Stillbirth in the pregnancy complicated by diabetes","volume":"15","author":"R Starikov","year":"2015","journal-title":"Curr Diab Rep"},{"issue":"9","key":"pone.0292094.ref005","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1007\/s00125-017-4314-3","article-title":"Improved pregnancy outcomes in women with type 1 and type 2 diabetes but substantial clinic-to-clinic variations: a prospective nationwide study","volume":"60","author":"HR Murphy","year":"2017","journal-title":"Diabetologia"},{"key":"pone.0292094.ref006","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications","author":"World Health Organization","year":"1999"},{"issue":"9","key":"pone.0292094.ref007","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1111\/dme.14292","article-title":"Barriers to completing oral glucose tolerance testing in women at risk of gestational diabetes","volume":"37","author":"EH Lachmann","year":"2020","journal-title":"Diabet Med"},{"issue":"5","key":"pone.0292094.ref008","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2337\/diab.23.5.449","article-title":"Insulin and Glucose Responses to Identical Oral Glucose Tolerance Tests Performed Forty-eight Hours Apart","volume":"23","author":"JM Olefsky","year":"1974","journal-title":"Diabetes"},{"issue":"12","key":"pone.0292094.ref009","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2337\/diab.15.12.901","article-title":"Reproducibility of the Oral Glucose Tolerance Test and the Rice-Meal Test in Mild Diabetics","volume":"15","author":"K Kosaka","year":"1966","journal-title":"Diabetes"},{"key":"pone.0292094.ref010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcjd.2019.02.004","article-title":"Self-Monitoring of Blood Glucose: A Complementary Method Beyond the Oral Glucose Tolerance Test to Identify Hyperglycemia During Pregnancy","author":"A Ardilouze","year":"2019","journal-title":"Can J Diabetes"},{"issue":"5","key":"pone.0292094.ref011","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/ajcn\/19.5.345","article-title":"Glucose tolerance test. 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