{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:06:27Z","timestamp":1778259987872,"version":"3.51.4"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Allergic rhinitis (AR) is a common atopic disease worldwide, and it was found that babies with constipation in their early life might have an increased risk of atopic diseases, including AR. Furthermore, recent studies also indicate that the maternal gut microbiota may influence babies. Thus, we extended the definition of early life in utero and evaluated the association between maternal constipation and the risk of AR in their babies. Using the Longitudinal Health Insurance Database, a subset of Taiwan\u2019s National Health Insurance Research Database, we identified 102,820 constipated mothers and 102,820 matched controls between 2005 and 2015. Propensity score analysis was used to match birth year, child sex, birth weight, gestational age, mode of delivery, maternal comorbidities, and children antibiotics taken. Multiple Cox regression and subgroup analyzes were conducted to estimate the adjusted hazard ratio of childhood AR. The incidence of childhood AR was 83.47 per 1,000 person-years in constipated mothers. Adjusting children\u2019s sex, birth weight, gestational age, mode of delivery, maternal comorbidities, and children antibiotic use, the results showed that the children whose mothers had constipation had a 1.20-fold risk of AR compared to children of mothers without constipation. Maternal constipation was associated with an increased risk of AR. Therefore, it is important to pay close attention to pregnant mothers with constipation.<\/jats:p>","DOI":"10.1371\/journal.pone.0292594","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T18:02:05Z","timestamp":1696528925000},"page":"e0292594","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maternal constipation is associated with allergic rhinitis in the offspring: A nationwide retrospective cohort study"],"prefix":"10.1371","volume":"18","author":[{"given":"Ming-Hung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Che","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hsun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-0679","authenticated-orcid":true,"given":"James Cheng-Chung","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"issue":"9","key":"pone.0292594.ref001","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1046\/j.1365-2222.2000.00853.x","article-title":"Preliminary criteria for the definition of allergic rhinitis: a systematic evaluation of clinical parameters in a disease cohort (I).","volume":"30","author":"ML Ng","year":"2000","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"pone.0292594.ref002","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jaci.2020.07.007","article-title":"Rhinitis 2020: A practice parameter update","volume":"146","author":"MS Dykewicz","year":"2020","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"pone.0292594.ref003","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2500\/aap.2009.30.3244","article-title":"The impact of allergic rhinitis on sexual activity, sleep, and fatigue","volume":"30","author":"MS Benninger","year":"2009","journal-title":"Allergy Asthma Proc"},{"issue":"Suppl 1:","key":"pone.0292594.ref004","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.2500\/aap.2012.33.3603","article-title":"Burden of allergic rhinitis: allergies in America, Latin America, and Asia-Pacific adult surveys","volume":"33","author":"EO Meltzer","year":"2012","journal-title":"Allergy Asthma Proc"},{"issue":"1","key":"pone.0292594.ref005","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1067\/mai.2001.115569","article-title":"Allergic rhinitis: Definition, epidemiology, pathophysiology, detection, and diagnosis","volume":"108","author":"DP Skoner","year":"2001","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"6","key":"pone.0292594.ref006","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jaci.2003.09.015","article-title":"Allergic rhinitis: systemic inflammation and implications for management","volume":"112","author":"L. 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