{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:38:51Z","timestamp":1789605531536,"version":"build-2803163510"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["INCT\/FAPERG 17\/2551-0000519-8"],"award-info":[{"award-number":["INCT\/FAPERG 17\/2551-0000519-8"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundo de apoio \u00e0 pesquisa Hospital de Clinicas de Porto Alegre","award":["FIPE 100243"],"award-info":[{"award-number":["FIPE 100243"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["INCT\/CNPq 465482\/2014-7"],"award-info":[{"award-number":["INCT\/CNPq 465482\/2014-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Although current evidence suggests increased risk of obesity, insulin resistance, and metabolic alterations in patients with polycystic ovary syndrome (PCOS), especially of a hyperandrogenic phenotype, the impact of each one of these variables on muscle mass remains uncertain. In this case-control study, we evaluated clinical and hormonal characteristics related to lean body mass according to the different PCOS phenotypes. We performed clinical, metabolic, and hormonal assessments and evaluated body compartments by dual-energy X-ray absorptiometry in 133 women of reproductive age. Creatinine served as an indirect marker of lean mass. Median age was 28 (range, 17\u201337) years. Women with phenotypes A and B (n = 59) had higher body mass index (BMI) and metabolic syndrome prevalence than those with phenotype C (n = 23) and controls (n = 51) (p<jats:bold>&lt;<\/jats:bold>0.005). Women with phenotypes A and B also had higher Ferriman-Gallwey score (p&lt;0.001), insulin levels (p = 0.006), HOMA-IR (p = 0.008), testosterone (p = 0.008), free androgen index (FAI) (p&lt;0.001), fat mass index (FMI) (p = 0.015), android-to-gynoid fat ratio (p = 0.036), and bone mineral density (BMD) at lumbar spine (p = 0.027) and total femur (p = 0.013) than controls. Median appendicular lean mass index (ALMI) was higher in phenotypes A and B than in controls (7.01 [IQR, 6.33\u20138.02] vs. 6.69 [IQR, 5.94\u20137.09], p = 0.024), but it did not differ significantly from that in phenotype C (6.60 [IQR, 6.16\u20137.22], p = 0.222). Even after adjusting for BMI, ALMI correlated positively with creatinine in women with phenotypes A and B (rho = 0.319, p = 0.023) but not in those with phenotype C (p = 0.238) or controls (p = 0.097). In multivariate linear regression analyses, ALMI was positively associated with insulin, FAI, FMI, and total femur BMD. The present results suggest that fasting insulin, FAI, fat mass, and total femur BMD were positively associated with increased lean mass in women with PCOS phenotypes A and B.<\/jats:p>","DOI":"10.1371\/journal.pone.0292623","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T17:51:03Z","timestamp":1696528263000},"page":"e0292623","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lean mass and associated factors in women with PCOS with different phenotypes"],"prefix":"10.1371","volume":"18","author":[{"given":"Tayane Muniz","family":"Fighera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00e2nia Rodrigues","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-7688","authenticated-orcid":true,"given":"Poli Mara","family":"Spritzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"issue":"9","key":"pone.0292623.ref001","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"33","author":"HJ Teede","year":"2018","journal-title":"Hum Reprod"},{"issue":"1","key":"pone.0292623.ref002","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertil Steril"},{"issue":"1","key":"pone.0292623.ref003","doi-asserted-by":"crossref","first-page":"e3464","DOI":"10.1002\/dmrr.3464","article-title":"Metabolic syndrome and its components in different phenotypes of polycystic ovary syndrome","volume":"38","author":"A Krentowska","year":"2022","journal-title":"Diabetes Metab Res Rev"},{"issue":"6","key":"pone.0292623.ref004","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.fertnstert.2010.02.015","article-title":"Variation in metabolic and cardiovascular risk in women with different polycystic ovary syndrome phenotypes","volume":"94","author":"D Wiltgen","year":"2010","journal-title":"Fertil Steril"},{"issue":"4","key":"pone.0292623.ref005","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3390\/jcm10040829","article-title":"Risk of Insulin Resistance and Metabolic Syndrome in Women with Hyperandrogenemia: A Comparison between PCOS Phenotypes and Beyond.","volume":"10","author":"V Borzan","year":"2021","journal-title":"J Clin Med."},{"key":"pone.0292623.ref006","volume-title":"Polycystic Ovary Syndrome. Challenging Issues in the Modern Era of Individualized Medicine.","author":"P. Moghetti","year":"2022"},{"key":"pone.0292623.ref007","volume-title":"Polycystic Ovary Syndrome. Challenging Issues in the Modern Era of Individualized Medicine.","author":"PM Spritzer","year":"2022"},{"key":"pone.0292623.ref008","doi-asserted-by":"crossref","first-page":"1085656","DOI":"10.3389\/fendo.2022.1085656","article-title":"Relationship between body composition, insulin resistance, and hormonal profiles in women with polycystic ovary syndrome","volume":"13","author":"H Zhang","year":"2023","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"3","key":"pone.0292623.ref009","doi-asserted-by":"crossref","first-page":"e22699","DOI":"10.1002\/jcla.22699","article-title":"Close correlation between hyperandrogenism and insulin resistance in women with polycystic ovary syndrome-Based on liquid chromatography with tandem mass spectrometry measurements.","volume":"33","author":"Y Yang","year":"2019","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"pone.0292623.ref010","first-page":"146","article-title":"Prevalence of metabolic syndrome in patients of south of Brazil with 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Alberti","year":"2009","journal-title":"Circulation"},{"issue":"6","key":"pone.0292623.ref025","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","article-title":"Use and abuse of HOMA modeling","volume":"27","author":"TM Wallace","year":"2004","journal-title":"Diabetes Care"},{"issue":"1","key":"pone.0292623.ref026","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s42358-022-00240-9","article-title":"Official Position of the Brazilian Association of Bone Assessment and Metabolism (ABRASSO) on the evaluation of body composition by densitometry-part II (clinical aspects): interpretation, reporting, and special situations.","volume":"62","author":"SS Maeda","year":"2022","journal-title":"Adv Rheumatol"},{"issue":"1","key":"pone.0292623.ref027","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1186\/s12891-022-06076-0","article-title":"The impact of obesity on the accuracy of DXA BMD for DXA-equivalent BMD 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intraperitoneal and mesenteric adipose tissue depots are increased in women with polycystic ovary syndrome (PCOS).","volume":"98","author":"S Borruel","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"pone.0292623.ref031","doi-asserted-by":"crossref","first-page":"R219","DOI":"10.1530\/REP-14-0435","article-title":"Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome","volume":"149","author":"PM Spritzer","year":"2015","journal-title":"Reproduction"},{"issue":"6","key":"pone.0292623.ref032","doi-asserted-by":"crossref","first-page":"375","DOI":"10.29252\/ijrm.15.6.375","article-title":"Polycystic ovary syndrome and circulating inflammatory markers","volume":"15","author":"F Zafari Zangeneh","year":"2017","journal-title":"Int J Reprod Biomed"},{"issue":"1","key":"pone.0292623.ref033","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.fertnstert.2011.11.023","article-title":"Is PCOS an inflammatory 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Pellegrino","year":"2022","journal-title":"Sports Med."},{"key":"pone.0292623.ref037","doi-asserted-by":"crossref","first-page":"569904","DOI":"10.3389\/fnut.2020.569904","article-title":"Exploring the Impact of Obesity on Skeletal Muscle Function in Older Age.","volume":"7","author":"PT Morgan","year":"2020","journal-title":"Front Nutr"},{"issue":"2","key":"pone.0292623.ref038","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/jcsm.12901","article-title":"Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review.","volume":"13","author":"CW Li","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"5","key":"pone.0292623.ref039","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1210\/er.2018-00020","article-title":"Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance","volume":"39","author":"DJ Handelsman","year":"2018","journal-title":"Endocr Rev"},{"issue":"10","key":"pone.0292623.ref040","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1136\/bjsports-2018-100525","article-title":"Effects of moderately increased testosterone concentration on physical performance in young women: a double blind, randomised, placebo controlled study","volume":"54","author":"AL Hirschberg","year":"2020","journal-title":"Br J Sports Med"},{"issue":"3","key":"pone.0292623.ref041","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/humrep\/des463","article-title":"Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp","volume":"28","author":"NK Stepto","year":"2013","journal-title":"Hum Reprod"},{"issue":"2","key":"pone.0292623.ref042","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1172\/JCI118126","article-title":"Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome","volume":"96","author":"A Dunaif","year":"1995","journal-title":"J Clin Invest"},{"issue":"5","key":"pone.0292623.ref043","doi-asserted-by":"crossref","first-page":"E1047","DOI":"10.1152\/ajpendo.00361.2004","article-title":"Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling","volume":"288","author":"A Corbould","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"pone.0292623.ref044","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications","volume":"33","author":"E Diamanti-Kandarakis","year":"2012","journal-title":"Endocr 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Densitom"},{"issue":"4","key":"pone.0292623.ref048","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/cbf.1668","article-title":"Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells","volume":"28","author":"J Yang","year":"2010","journal-title":"Cell Biochem Funct"},{"issue":"4","key":"pone.0292623.ref049","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1210\/jc.2016-3282","article-title":"Bone Turnover Is Suppressed in Insulin Resistance, Independent of Adiposity","volume":"102","author":"KT Tonks","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"pone.0292623.ref050","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00198-016-3710-8","article-title":"Discordance between fat mass index and body mass index is associated with reduced bone mineral density in women but not in men: the Busselton Healthy Ageing Study","volume":"28","author":"K Zhu","year":"2017","journal-title":"Osteoporos Int"},{"issue":"2","key":"pone.0292623.ref051","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1530\/JOE-16-0405","article-title":"Hormonal alterations in PCOS and its influence on bone metabolism","volume":"232","author":"A Krishnan","year":"2017","journal-title":"J Endocrinol"},{"issue":"5","key":"pone.0292623.ref052","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/jcb.25040","article-title":"Interactions between muscle tissues and bone metabolism","volume":"116","author":"N Kawao","year":"2015","journal-title":"J Cell Biochem"},{"key":"pone.0292623.ref053","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejim.2019.10.025","article-title":"Creatinine: From physiology to clinical application","volume":"72","author":"K Kashani","year":"2020","journal-title":"Eur J Intern 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