{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:34:52Z","timestamp":1789565692675,"version":"build-2803163510"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K21003"],"award-info":[{"award-number":["22K21003"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K10305"],"award-info":[{"award-number":["20K10305"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K10304"],"award-info":[{"award-number":["20K10304"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K17171"],"award-info":[{"award-number":["21K17171"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K24109"],"award-info":[{"award-number":["19K24109"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K10255"],"award-info":[{"award-number":["22K10255"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K10242"],"award-info":[{"award-number":["21K10242"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Although angiotensin converting enzyme (ACE) inhibitors are considered useful for the treatment of human heart failure, some experimental failing-heart models have shown little beneficial effect of ACE inhibitors in animals with poor oral health, particularly periodontitis. In this study, we examined the effects of the ACE inhibitor captopril (Cap; 0.1 mg\/mL in drinking water) on cardiac dysfunction in mice treated with <jats:italic>Porphyromonas gingivalis<\/jats:italic> lipopolysaccharide (PG-LPS) at a dose (0.8 mg\/kg\/day) equivalent to the circulating level in patients with periodontal disease. Mice were divided into four groups: 1) Control, 2) PG-LPS, 3) Cap, and 4) PG-LPS + Cap. After1 week, we evaluated cardiac function by echocardiography. The left ventricular ejection fraction was significantly decreased in PG-LPS-treated mice compared to the control (from 66 \u00b1 1.8 to 59 \u00b1 2.5%), while Cap ameliorated the dysfunction (63 \u00b1 1.1%). The area of cardiac fibrosis was significantly increased (approximately 2.9-fold) and the number of apoptotic myocytes was significantly increased (approximately 5.6-fold) in the heart of PG-LPS-treated group versus the control, and these changes were suppressed by Cap. The impairment of cardiac function in PG-LPS-treated mice was associated with protein kinase C \u03b4 phosphorylation (Tyr-311), leading to upregulation of NADPH oxidase 4 and xanthine oxidase, and calmodulin kinase II phosphorylation (Thr-286) with increased phospholamban phosphorylation (Thr-17). These changes were also suppressed by Cap. Our results suggest that the renin-angiotensin system might play an important role in the development of cardiac diseases induced by PG-LPS.<\/jats:p>","DOI":"10.1371\/journal.pone.0292624","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T18:25:23Z","timestamp":1700504723000},"page":"e0292624","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral angiotensin-converting enzyme inhibitor captopril protects the heart from Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice"],"prefix":"10.1371","volume":"18","author":[{"given":"Kenichi","family":"Kiyomoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Ohnuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misao","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Mototani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinori","family":"Tsunoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinaka","family":"Morii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Nariyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Amitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Gomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8747-7941","authenticated-orcid":true,"given":"Satoshi","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"issue":"5","key":"pone.0292624.ref001","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/07853890.2020.1758341","article-title":"Local ocular renin-angiotensin-aldosterone system: any connection with intraocular pressure? A comprehensive review","volume":"52","author":"M Holappa","year":"2020","journal-title":"Ann Med"},{"issue":"4","key":"pone.0292624.ref002","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1161\/HYPERTENSIONAHA.110.155895","article-title":"Aging and the renin-angiotensin system","volume":"60","author":"S Conti","year":"2012","journal-title":"Hypertension"},{"issue":"4","key":"pone.0292624.ref003","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.job.2021.10.001","article-title":"Effects of chronic Porphylomonas gingivalis lipopolysaccharide infusion on cardiac dysfunction in mice.","volume":"63","author":"I Matsuo","year":"2021","journal-title":"J Oral Biosci"},{"issue":"4","key":"pone.0292624.ref004","doi-asserted-by":"crossref","first-page":"e0215539","DOI":"10.1371\/journal.pone.0215539","article-title":"Role of \u03b2-adrenergic signaling in masseter muscle.","volume":"14","author":"A Ito","year":"2019","journal-title":"PLoS One."},{"issue":"12a","key":"pone.0292624.ref005","doi-asserted-by":"crossref","first-page":"80H","DOI":"10.1016\/S0002-9149(99)00266-0","article-title":"\u03b2-adrenergic receptor-G protein-adenylyl cyclase signal transduction in the failing heart","volume":"83","author":"DE Vatner","year":"1999","journal-title":"Am J Cardiol"},{"issue":"6","key":"pone.0292624.ref006","doi-asserted-by":"crossref","first-page":"e0258823","DOI":"10.1371\/journal.pone.0258823","article-title":"Role of TLR4 signaling on Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice.","volume":"17","author":"I Matsuo","year":"2022","journal-title":"PLoS One."},{"issue":"1","key":"pone.0292624.ref007","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12576-022-00826-4","article-title":"Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in mice","volume":"72","author":"Y Hayakawa","year":"2022","journal-title":"J Physiol Sci"},{"issue":"1","key":"pone.0292624.ref008","doi-asserted-by":"crossref","first-page":"13765","DOI":"10.1038\/s41598-020-70791-8","article-title":"Effects of occlusal disharmony on susceptibility to atrial fibrillation in mice.","volume":"10","author":"K Suita","year":"2020","journal-title":"Sci Rep."},{"issue":"5","key":"pone.0292624.ref009","first-page":"e00079","article-title":"Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism.","volume":"1","author":"KY Deleon-Pennell","year":"2013","journal-title":"Physiol Rep."},{"issue":"1","key":"pone.0292624.ref010","doi-asserted-by":"crossref","first-page":"346","DOI":"10.4049\/jimmunol.171.1.346","article-title":"Captopril prevents experimental autoimmune myocarditis","volume":"171","author":"LM Godsel","year":"2003","journal-title":"J Immunol"},{"issue":"1","key":"pone.0292624.ref011","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijcard.2007.04.062","article-title":"Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis","volume":"125","author":"TJ Bahk","year":"2008","journal-title":"Int J Cardiol"},{"issue":"Pt 22","key":"pone.0292624.ref012","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1113\/jphysiol.2011.218255","article-title":"The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth","volume":"589","author":"CA Goodman","year":"2011","journal-title":"J Physiol"},{"issue":"11","key":"pone.0292624.ref013","doi-asserted-by":"crossref","first-page":"e7824","DOI":"10.1371\/journal.pone.0007824","article-title":"Survey of the quality of experimental design, statistical analysis and reporting of research using animals.","volume":"4","author":"C Kilkenny","year":"2009","journal-title":"PLoS One."},{"key":"pone.0292624.ref014","volume-title":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals","author":"National Research Council (US)","year":"2011","edition":"18"},{"issue":"6","key":"pone.0292624.ref015","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1172\/JCI64784","article-title":"Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses","volume":"124","author":"S Okumura","year":"2014","journal-title":"J Clin Invest"},{"issue":"1","key":"pone.0292624.ref016","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0002-9149(76)90491-4","article-title":"Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy.","volume":"37","author":"LE Teichholz","year":"1976","journal-title":"Am J Cardiol"},{"key":"pone.0292624.ref017","doi-asserted-by":"crossref","first-page":"963762","DOI":"10.3389\/fphys.2022.963762","article-title":"Caloric restriction prevents obesity- and intermittent hypoxia-induced cardiac remodeling in leptin-deficient mice.","volume":"13","author":"AA Jones","year":"2022","journal-title":"Front Physiol"},{"issue":"8","key":"pone.0292624.ref018","doi-asserted-by":"crossref","first-page":"e104357","DOI":"10.1371\/journal.pone.0104357","article-title":"Novel methods of automated quantification of gap junction distribution and interstitial collagen quantity from animal and human atrial tissue sections.","volume":"9","author":"J Yan","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"pone.0292624.ref019","doi-asserted-by":"crossref","first-page":"16972","DOI":"10.1038\/s41598-018-35394-4","article-title":"Quantitative gadolinium-free cardiac fibrosis imaging in end stage renal disease patients reveals a longitudinal correlation with structural and functional decline.","volume":"8","author":"TA Stromp","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"pone.0292624.ref020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2016.04.123","article-title":"Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction","volume":"475","author":"W Cai","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"17","key":"pone.0292624.ref021","doi-asserted-by":"crossref","first-page":"9986","DOI":"10.1073\/pnas.1733772100","article-title":"Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload","volume":"100","author":"S Okumura","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"pone.0292624.ref022","doi-asserted-by":"crossref","first-page":"e20334","DOI":"10.1371\/journal.pone.0020334","article-title":"The rat IgGFc\u03b3BP and Muc2 C-terminal domains and TFF3 in two intestinal mucus layers bind together by covalent interaction.","volume":"6","author":"H Yu","year":"2011","journal-title":"PLoS One."},{"issue":"4","key":"pone.0292624.ref023","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/01.RES.0000086986.35568.63","article-title":"Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation","volume":"93","author":"S Okumura","year":"2003","journal-title":"Circ Res"},{"issue":"6","key":"pone.0292624.ref024","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/ajh.2011.42","article-title":"Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion","volume":"24","author":"J Ren","year":"2011","journal-title":"Am J Hypertens"},{"issue":"7","key":"pone.0292624.ref025","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1161\/ATVBAHA.112.249706","article-title":"Interleukin-12p35 deletion promotes CD4 T-cell-dependent macrophage differentiation and enhances angiotensin II-Induced cardiac fibrosis","volume":"32","author":"Y Li","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"pone.0292624.ref026","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"J. Cohen","year":"1992","journal-title":"Psychol Bull"},{"issue":"4","key":"pone.0292624.ref027","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses.","volume":"41","author":"F Faul","year":"2009","journal-title":"Behav Res Methods"},{"issue":"20","key":"pone.0292624.ref028","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1161\/CIRCULATIONAHA.117.028752","article-title":"Fibroblast primary cilia are required for cardiac fibrosis","volume":"139","author":"E Villalobos","year":"2019","journal-title":"Circulation"},{"issue":"4","key":"pone.0292624.ref029","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.bbrc.2009.06.076","article-title":"Role of protein kinase C-\u03b4 in angiotensin II induced cardiac fibrosis","volume":"386","author":"V Chintalgattu","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0292624.ref030","doi-asserted-by":"crossref","first-page":"816369","DOI":"10.3389\/fcvm.2022.816369","article-title":"Role and mechanism of PKC-\u03b4 for cardiovascular disease: current status and perspective.","volume":"9","author":"LN Miao","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"5","key":"pone.0292624.ref031","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/jcp.25210","article-title":"The Nox1\/4 dual inhibitor GKT137831 or Nox4 knockdown inhibits angiotensin-II-induced adult mouse cardiac fibroblast proliferation and migration. AT1 physically associates with Nox4","volume":"231","author":"NK Somanna","year":"2016","journal-title":"J Cell Physiol"},{"issue":"4","key":"pone.0292624.ref032","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12265-010-9184-8","article-title":"NADPH oxidase and cardiac failure","volume":"3","author":"J Kuroda","year":"2010","journal-title":"J Cardiovasc Transl Res"},{"issue":"Pt 1","key":"pone.0292624.ref033","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1042\/bj3060225","article-title":"Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide","volume":"306","author":"M Kurosaki","year":"1995","journal-title":"Biochem J"},{"issue":"2","key":"pone.0292624.ref034","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1365-201X.1996.492235000.x","article-title":"Increased expression of xanthine oxidase and insulin-like growth factor I (IGF-I) immunoreactivity in skeletal muscle after strenuous exercise in humans.","volume":"157","author":"Y Hellsten","year":"1996","journal-title":"Acta Physiol Scand"},{"key":"pone.0292624.ref035","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.yjmcc.2014.02.004","article-title":"CaMKII oxidative activation and the pathogenesis of cardiac disease","volume":"73","author":"ED Luczak","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"pone.0292624.ref036","doi-asserted-by":"crossref","first-page":"734210","DOI":"10.3389\/fphys.2021.734210","article-title":"RyR2 and calcium release in heart failure","volume":"12","author":"JP Benitah","year":"2021","journal-title":"Front Physiol"},{"key":"pone.0292624.ref037","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.yjmcc.2019.08.006","article-title":"Tachycardia-induced CD44\/NOX4 signaling is involved in the development of atrial remodeling","volume":"135","author":"WJ Chen","year":"2019","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"pone.0292624.ref038","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/00365520510015430","article-title":"Tnon-cardia adenocarcinoma in a cohort of Finnish smokers","volume":"40","author":"CC Abnet","year":"2005","journal-title":"Scand J Gastroenterol"},{"issue":"4","key":"pone.0292624.ref039","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/MAJ.0b013e31828bdedf","article-title":"Oral health and type 2 diabetes","volume":"345","author":"RS Leite","year":"2013","journal-title":"Am J Med Sci"},{"issue":"1","key":"pone.0292624.ref040","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/prd.12294","article-title":"Periodontal disease and adverse pregnancy outcomes.","volume":"83","author":"YA Bobetsis","year":"2020","journal-title":"Periodontol. 2000"},{"issue":"1","key":"pone.0292624.ref041","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/prd.12422","article-title":"Osteoporosis and periodontal diseases\u2014An update on their association and mechanistic links.","volume":"89","author":"B Yu","year":"2022","journal-title":"Periodontol. 2000."},{"issue":"1","key":"pone.0292624.ref042","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1741-2358.2012.00637.x","article-title":"Oral health care and aspiration pneumonia in frail older people: a systematic literature review.","volume":"30","author":"CD van der Maarel-Wierink","year":"2013","journal-title":"Gerodontology"},{"key":"pone.0292624.ref043","article-title":"The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment","author":"Q Feng","journal-title":"Nat Med."},{"issue":"9","key":"pone.0292624.ref044","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/CIRCRESAHA.110.226936","article-title":"The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls","volume":"108","author":"DL Mann","year":"2011","journal-title":"Circ Res"},{"issue":"9","key":"pone.0292624.ref045","doi-asserted-by":"crossref","first-page":"e107556","DOI":"10.1371\/journal.pone.0107556","article-title":"Myocardial fibrosis induced by exposure to subclinical lipopolysaccharide is associated with decreased miR-29c and enhanced NOX2 expression in mice.","volume":"9","author":"WY Lew","year":"2014","journal-title":"PLoS One"},{"key":"pone.0292624.ref046","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biochi.2019.04.013","article-title":"TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid","volume":"162","author":"J Zhang","year":"2019","journal-title":"Biochimie"},{"key":"pone.0292624.ref047","doi-asserted-by":"crossref","first-page":"6193407","DOI":"10.1155\/2020\/6193407","article-title":"The interplay of renin-angiotensin system and Toll-like receptor 4 in the inflammation of diabetic nephropathy","volume":"2020","author":"Q Feng","year":"2020","journal-title":"J Immunol Res"},{"key":"pone.0292624.ref048","doi-asserted-by":"crossref","first-page":"101186","DOI":"10.1016\/j.redox.2019.101186","article-title":"TLR4 participates in sympathetic hyperactivity Post-MI in the PVN by regulating NF-\u03baB pathway and ROS production.","volume":"24","author":"Y Wang","year":"2019","journal-title":"Redox Biol"},{"issue":"9b","key":"pone.0292624.ref049","doi-asserted-by":"crossref","first-page":"9J","DOI":"10.1016\/S0002-9149(97)00832-1","article-title":"The sympathetic nervous system and the renin-angiotensin-aldosterone system in cardiovascular disease","volume":"80","author":"RJ Cody","year":"1997","journal-title":"Am J Cardiol"},{"issue":"19","key":"pone.0292624.ref050","doi-asserted-by":"crossref","first-page":"13553","DOI":"10.1016\/S0021-9258(18)42247-8","article-title":"Isolation and characterization of a novel cardiac adenylylcyclase cDNA","volume":"267","author":"Y Ishikawa","year":"1992","journal-title":"J Biol Chem"},{"issue":"1","key":"pone.0292624.ref051","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/01.HYP.0000250708.04205.d4","article-title":"Decreased intracellular calcium stimulates renin release via calcium-inhibitable adenylyl cyclase","volume":"49","author":"MC Ortiz-Capisano","year":"2007","journal-title":"Hypertension"},{"issue":"1","key":"pone.0292624.ref052","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1083\/jcb.117.1.121","article-title":"Tissue and cellular distribution of the extended family of protein kinase C isoenzymes","volume":"117","author":"WC Wetsel","year":"1992","journal-title":"J Cell Biol"},{"issue":"1\u20133","key":"pone.0292624.ref053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-0115(99)00123-8","article-title":"The cardiac renin-angiotensin system: novel signaling mechanisms related to cardiac growth and function","volume":"91","author":"DE Dostal","year":"2000","journal-title":"Regul Pept"},{"issue":"5","key":"pone.0292624.ref054","doi-asserted-by":"crossref","first-page":"H2062","DOI":"10.1152\/ajpheart.2001.281.5.H2062","article-title":"Protein kinase C isoform expression and activity in the mouse heart","volume":"281","author":"KL Schreiber","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"pone.0292624.ref055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.apsb.2020.09.006","article-title":"Activated PKB\/GSK-3\u03b2 synergizes with PKC-\u03b4 signaling in attenuating myocardial ischemia\/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I.","volume":"11","author":"H Zeng","year":"2021","journal-title":"Acta Pharm Sin B"},{"issue":"12","key":"pone.0292624.ref056","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1073\/pnas.111158798","article-title":"Phosphorylation sites of protein kinase C \u03b4 in H2O2-treated cells and its activation by tyrosine kinase in vitro","volume":"98","author":"H Konishi","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"pone.0292624.ref057","first-page":"130","article-title":"Cardiac actions of protein kinase C isoforms.","volume":"27","author":"SF Steinberg","year":"2012","journal-title":"Physiology (Bethesda)."},{"issue":"1\u20132","key":"pone.0292624.ref058","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/B:MCBI.0000038231.68078.4b","article-title":"Diabetic cardiomyocyte dysfunction and myocyte insulin resistance: role of glucose-induced PKC activity","volume":"262","author":"AJ Davidoff","year":"2004","journal-title":"Mol Cell Biochem"},{"issue":"6","key":"pone.0292624.ref059","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.RES.67.6.1355","article-title":"Remodeling of the rat right and left ventricles in experimental hypertension","volume":"67","author":"CG Brilla","year":"1990","journal-title":"Circ Res"},{"issue":"3","key":"pone.0292624.ref060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/cvr\/27.3.341","article-title":"Myocardial fibrosis: functional significance and regulatory factors","volume":"27","author":"KT Weber","year":"1993","journal-title":"Cardiovasc Res"},{"issue":"9","key":"pone.0292624.ref061","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/0022-2828(95)90013-6","article-title":"Inhibition by angiotensin II type 1 receptor antagonist of cardiac phenotypic modulation after myocardial infarction","volume":"27","author":"A Hanatani","year":"1995","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"pone.0292624.ref062","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s11606-008-0787-6","article-title":"Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis","volume":"23","author":"LL Humphrey","year":"2008","journal-title":"J Gen Intern Med"},{"issue":"3","key":"pone.0292624.ref063","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: Consensus report.","volume":"47","author":"M Sanz","year":"2020","journal-title":"J Clin Periodontol"},{"key":"pone.0292624.ref064","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2018.09.026","article-title":"Associations between self-reported periodontal disease, assessed using a very short questionnaire, cardiovascular disease events and all-cause mortality in a contemporary multi-ethnic population: The Multi-Ethnic Study of Atherosclerosis (MESA).","volume":"278","author":"B Gonzalez-Navarro","year":"2018","journal-title":"Atherosclerosis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0292624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T18:26:05Z","timestamp":1700504765000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0292624"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":64,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0292624","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]}}}