{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:20:48Z","timestamp":1791332448118,"version":"4.3.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Histone deacetylase HDAC4 promotes retinal pigment epithelium inflammation and mitochondrial dysfunction in high glucose induced diabetes retinopathy","award":["YNKT202207"],"award-info":[{"award-number":["YNKT202207"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To comprehensively investigate risk factors for proliferative vitreoretinopathy (PVR) after retinal detachment (RD) surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, Cochrane Library, and Web of Science were systematically searched until May 22, 2023. Risk factors included demographic and disease-related risk factors. Odds ratios (ORs) and weighted mean differences (WMDs) were used as the effect sizes, and shown with 95% confidence intervals (CIs). Sensitivity analysis was conducted. The protocol was registered with PROSPERO (CRD42022378652).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-two studies of 13,875 subjects were included in this systematic review and meta-analysis. Increased age was associated with a higher risk of postoperative PVR (pooled WMD = 3.98, 95%CI: 0.21, 7.75,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.038). Smokers had a higher risk of postoperative PVR than non-smokers (pooled OR = 5.07, 95%CI: 2.21\u201311.61,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Presence of preoperative PVR was associated with a greater risk of postoperative PVR (pooled OR = 22.28, 95%CI: 2.54, 195.31,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005). Presence of vitreous hemorrhage was associated with a greater risk of postoperative PVR (pooled OR = 4.12, 95%CI: 1.62, 10.50,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003). Individuals with aphakia or pseudophakia had an increased risk of postoperative PVR in contrast to those without (pooled OR = 1.41, 95%CI: 1.02, 1.95,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.040). The risk of postoperative PVR was higher among patients with macula off versus those with macula on (pooled OR = 1.85, 95%CI: 1.24, 2.74,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002). Extent of RD in patients with postoperative PVR was larger than that in patients without (pooled WMD = 0.31, 95%CI: 0.02, 0.59,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.036). Patients with postoperative PVR had longer duration of RD symptoms than those without (pooled WMD = 10.36, 95%CI: 2.29, 18.43,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Age, smoking, preoperative PVR, vitreous hemorrhage, aphakia or pseudophakia, macula off, extent of RD, and duration of RD symptoms were risk factors for postoperative PVR in patients undergoing RD surgery, which may help better identify high-risk patients, and provide timely interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0292698","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T13:56:47Z","timestamp":1698674207000},"page":"e0292698","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Risk factors for proliferative vitreoretinopathy after retinal detachment surgery: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3180-7012","authenticated-orcid":true,"given":"Jinjin","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"issue":"4","key":"pone.0292698.ref001","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.survophthal.2012.12.004","article-title":"Pathophysiology of proliferative vitreoretinopathy in retinal detachment","volume":"58","author":"JG Garweg","year":"2013","journal-title":"Survey of ophthalmology"},{"key":"pone.0292698.ref002","first-page":"1325","article-title":"Proliferative vitreoretinopathy: current and emerging treatments","volume":"6","author":"A Sadaka","year":"2012","journal-title":"Clinical ophthalmology (Auckland, NZ)"},{"issue":"1","key":"pone.0292698.ref003","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00347-020-01173-8","article-title":"[Proliferative vitreoretinopathy prophylaxis: Mission (im)possible]","volume":"118","author":"F Schaub","year":"2021","journal-title":"Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft"},{"issue":"8","key":"pone.0292698.ref004","first-page":"653","article-title":"Proliferative vitreoretinopathy: curative treatment","volume":"37","author":"C Chiquet","year":"2014","journal-title":"Journal francais d\u2019ophtalmologie"},{"issue":"8","key":"pone.0292698.ref005","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1097\/IAE.0000000000002184","article-title":"PREDICTIVE FACTORS FOR PROLIFERATIVE VITREORETINOPATHY FORMATION AFTER UNCOMPLICATED PRIMARY RETINAL DETACHMENT REPAIR","volume":"39","author":"K Xu","year":"2019","journal-title":"Retina (Philadelphia, Pa)"},{"issue":"3","key":"pone.0292698.ref006","first-page":"201","article-title":"The development of severe proliferative vitreoretinopathy after retinal detachment surgery","volume":"226","author":"M. 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