{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:45:11Z","timestamp":1787899511852,"version":"build-2784847793"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>A complete blood count (CBC) is a routinely performed blood examination. Only a few studies assess the relationship between CBC and oxidative stress (OS) in schizophrenia (SZ). The aim of the study was to assess the utility of CBC in the prediction of SZ diagnosis, and the relationship between CBC and OS. The study included: 47 individuals with the first episode of psychosis (26 drug-naive: FEP-nt; 21 patients under antipsychotic treatment: FEP-t) and 30 healthy persons (control group, HC). CBC and oxidative stress-related parameters were assessed in blood samples. The FEP group had higher levels of WBC, MCHC, NEU, MONO, EOZ, BASO, and %EOZ compared to HC (p&lt;0.05). Various relationships between OS and CBC were found, and this connection was significantly different between healthy individuals and patients. The most promising C&amp;RT model for discriminating FEP from HC was combining monocytes, eosinophils, and neutrophils (accuracy: 77%, <jats:bold>95%CI = 0.67\u20130.87<\/jats:bold>). The analysis singled out WBC and HT (accuracy: 74%, <jats:bold>95%CI = 0.64\u20130.90<\/jats:bold>) as the most promising to distinguish FEP-nt from HC; WBC and %Neu to allocate to FEP-t or HC group (accuracy: 87%, <jats:bold>95%CI = 0.64\u20130.90<\/jats:bold>); RDW-SD and LYMPH (accuracy: 86%, <jats:bold>95% CI = 0.75\u201397<\/jats:bold>) for distinguishing FEP-nt from FEP-t. CBC could be a promising, cheap tool to determine abnormalities related to schizophrenia. However, more studies with larger sample sizes are required.<\/jats:p>","DOI":"10.1371\/journal.pone.0292756","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T17:32:53Z","timestamp":1697131973000},"page":"e0292756","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["The usefulness of a complete blood count in the prediction of the first episode of schizophrenia diagnosis and its relationship with oxidative stress"],"prefix":"10.1371","volume":"18","author":[{"given":"Dariusz","family":"Juchnowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Dzikowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Rog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napoleon","family":"Waszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-8502","authenticated-orcid":true,"given":"Kaja Hanna","family":"Karaku\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zalewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5609-3187","authenticated-orcid":true,"given":"Mateusz","family":"Maciejczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Karakula-Juchnowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"pone.0292756.ref001","doi-asserted-by":"crossref","first-page":"E2348","DOI":"10.3390\/cancers12092348","article-title":"The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal","volume":"12","author":"PS Virdee","year":"2020","journal-title":"Cancers (Basel)"},{"key":"pone.0292756.ref002","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/0003319715615252","article-title":"The Neutrophil-Lymphocyte Ratio and Inflammation","volume":"67","author":"S Balta","year":"2016","journal-title":"Angiology"},{"key":"pone.0292756.ref003","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41598-020-79431-7","article-title":"Neutrophil-to-Lymphocyte Ratio and Mortality in the United States General Population","volume":"11","author":"M Song","year":"2021","journal-title":"Sci Rep"},{"key":"pone.0292756.ref004","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.hgmx.2016.06.011","article-title":"Low-Grade Inflammation and Its Relation to Obesity and Chronic Degenerative Diseases","volume":"80","author":"AM Castro","year":"2017","journal-title":"Revista M\u00e9dica del Hospital General de M\u00e9xico"},{"key":"pone.0292756.ref005","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/schbul\/sby125","article-title":"Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-Analysis","volume":"45","author":"D Fraguas","year":"2019","journal-title":"Schizophr Bull"},{"key":"pone.0292756.ref006","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/eip.12859","article-title":"Role of Inflammation in the Pathogenesis of Schizophrenia: A Review of the Evidence, Proposed Mechanisms and Implications for Treatment","volume":"14","author":"D Mongan","year":"2020","journal-title":"Early Interv Psychiatry"},{"key":"pone.0292756.ref007","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/HRP.0000000000000321","article-title":"Inflammation Subtypes and Translating Inflammation-Related Genetic Findings in Schizophrenia and Related Psychoses: A Perspective on Pathways for Treatment Stratification and Novel Therapies","volume":"30","author":"JR Bishop","year":"2022","journal-title":"Harv Rev Psychiatry"},{"key":"pone.0292756.ref008","doi-asserted-by":"crossref","first-page":"105200","DOI":"10.1016\/j.psyneuen.2021.105200","article-title":"Immune-Inflammatory Markers and Psychosis Risk: A Systematic Review and Meta-Analysis","volume":"127","author":"B Misiak","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"pone.0292756.ref009","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1245\/s10434-015-4781-z","article-title":"The Prognostic Significance of Inflammation-Associated Blood Cell Markers in Patients with Upper Tract Urothelial Carcinoma","volume":"23","author":"Y-C Cheng","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"pone.0292756.ref010","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.12659\/MSM.906709","article-title":"Clinical Significance of Routine Blood Test-Associated Inflammatory Index in Breast Cancer Patients","volume":"23","author":"H Sun","year":"2017","journal-title":"Med Sci Monit"},{"key":"pone.0292756.ref011","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.psychres.2018.11.043","article-title":"Neutrophil\/Lymphocyte, Platelet\/Lymphocyte and Monocyte\/Lymphocyte Ratios in Different Stages of Schizophrenia","volume":"271","author":"S \u00d6zdin","year":"2019","journal-title":"Psychiatry Res"},{"key":"pone.0292756.ref012","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4306\/pi.2016.13.1.121","article-title":"Increased Neutrophil\/Lymphocyte Ratio in Patients with Depression Is Correlated with the Severity of Depression and Cardiovascular Risk Factors","volume":"13","author":"E Aydin Sunbul","year":"2016","journal-title":"Psychiatry Investig"},{"key":"pone.0292756.ref013","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/brainsci11010058","article-title":"Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder","volume":"11","author":"L Fusar-Poli","year":"2021","journal-title":"Brain Sci"},{"key":"pone.0292756.ref014","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.comppsych.2016.01.005","article-title":"Neutrophil-to-Lymphocyte Ratio Predicting Suicide Risk in Euthymic Patients with Bipolar Disorder: Moderatory Effect of Family History","volume":"66","author":"M Ivkovi\u0107","year":"2016","journal-title":"Compr Psychiatry"},{"key":"pone.0292756.ref015","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3390\/jcm11010232","article-title":"Effect of Antipsychotic Treatment on Neutrophil-to-Lymphocyte Ratio during Hospitalization for Acute Psychosis in the Course of Schizophrenia-A Cross-Sectional Retrospective Study","volume":"11","author":"B Dawidowski","year":"2021","journal-title":"J Clin Med"},{"key":"pone.0292756.ref016","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.2147\/NDT.S110484","article-title":"Relationship between Neutrophil\/Lymphocyte Ratio with Oxidative Stress and Psychopathology in Patients with Schizophrenia","volume":"12","author":"B Kulaksizoglu","year":"2016","journal-title":"Neuropsychiatr Dis Treat"},{"key":"pone.0292756.ref017","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/15622975.2019.1583371","article-title":"Neutrophil-Lymphocyte Ratio, Monocyte-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Non-Affective Psychosis: A Meta-Analysis and Systematic Review","volume":"21","author":"MG Mazza","year":"2020","journal-title":"World J Biol Psychiatry"},{"key":"pone.0292756.ref018","doi-asserted-by":"crossref","first-page":"100453","DOI":"10.1016\/j.bbih.2022.100453","article-title":"Is There an Association between Inflammatory\/Anti-Oxidant Markers and the Presence of Psychotic Symptoms or Severity of Illness in Mood and Psychotic Disorders? A Multi-Centric Study on a Drug-Free Sample","volume":"22","author":"A Caldiroli","year":"2022","journal-title":"Brain Behav Immun Health"},{"key":"pone.0292756.ref019","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.3390\/jcm10184156","article-title":"Pro\/Antioxidant State as a Potential Biomarker of Schizophrenia","volume":"10","author":"D Juchnowicz","year":"2021","journal-title":"J Clin Med"},{"key":"pone.0292756.ref020","doi-asserted-by":"crossref","first-page":"104473","DOI":"10.1016\/j.psyneuen.2019.104473","article-title":"Interaction of Oxidative Stress and BDNF on Executive Dysfunction in Patients with Chronic Schizophrenia","volume":"111","author":"C Wei","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"pone.0292756.ref021","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pnpbp.2012.07.016","article-title":"Schizophrenia Is Primed for an Increased Expression of Depression through Activation of Immuno-Inflammatory, Oxidative and Nitrosative Stress, and Tryptophan Catabolite Pathways","volume":"42","author":"G Anderson","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"pone.0292756.ref022","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1177\/1039856220908172","article-title":"Neutrophil-Lymphocyte Ratio\u2014a Simple, Accessible Measure of Inflammation, Morbidity and Prognosis in Psychiatric Disorders?","volume":"28","author":"Z Zulfic","year":"2020","journal-title":"Australas Psychiatry"},{"key":"pone.0292756.ref023","doi-asserted-by":"crossref","first-page":"112","DOI":"10.9758\/cpn.2021.19.1.112","article-title":"Elevated Monocyte to High-Density Lipoprotein Ratios as an Inflammation Markers for Schizophrenia Patients","volume":"19","author":"M Sahpolat","year":"2021","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"pone.0292756.ref024","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.3389\/fimmu.2018.02230","article-title":"C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls","volume":"9","author":"I Jacomb","year":"2018","journal-title":"Front Immunol"},{"key":"pone.0292756.ref025","unstructured":"Diagnostic and Statistical Manual of Mental Disorders: DSM-5; American Psychiatric Association, American Psychiatric Association, Eds.; 5th ed.; American Psychiatric Association: Washington, D.C. 2013. ISBN 978-0-89042-554-1."},{"key":"pone.0292756.ref026","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"key":"pone.0292756.ref027","doi-asserted-by":"crossref","first-page":"728986","DOI":"10.3389\/fpsyt.2021.728986","article-title":"Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia","volume":"12","author":"D Juchnowicz","year":"2021","journal-title":"Front Psychiatry"},{"issue":"Suppl 1","key":"pone.0292756.ref028","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1093\/schbul\/sbv167","article-title":"Dose Equivalents for Antipsychotic Drugs: The DDD Method","volume":"42","author":"S Leucht","year":"2016","journal-title":"Schizophr Bull"},{"key":"pone.0292756.ref029","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia","volume":"13","author":"SR Kay","year":"1987","journal-title":"Schizophr Bull"},{"key":"pone.0292756.ref030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2008.04.007","article-title":"Logistic Regression and CART in the Analysis of Multimarker Studies","volume":"394","author":"R Muller","year":"2008","journal-title":"Clin Chim Acta"},{"key":"pone.0292756.ref031","unstructured":"Lewis RJ. An Introduction to Classification and Regression Tree (CART) Analysis. 14."},{"key":"pone.0292756.ref032","doi-asserted-by":"crossref","first-page":"114382","DOI":"10.1016\/j.psychres.2021.114382","article-title":"Complete Blood Count Inflammatory Markers in Treatment-Resistant Schizophrenia: Evidence of Association between Treatment Responsiveness and Levels of Inflammation","volume":"308","author":"C Labont\u00e9","year":"2022","journal-title":"Psychiatry Res"},{"key":"pone.0292756.ref033","doi-asserted-by":"crossref","first-page":"703452","DOI":"10.3389\/fpsyt.2021.703452","article-title":"Oxidative Stress and the Pathophysiology and Symptom Profile of Schizophrenia Spectrum Disorders","volume":"12","author":"AJ Murray","year":"2021","journal-title":"Front Psychiatry"},{"key":"pone.0292756.ref034","doi-asserted-by":"crossref","first-page":"627","DOI":"10.14202\/vetworld.2018.627-635","article-title":"The Crucial Roles of Inflammatory Mediators in Inflammation: A Review","volume":"11","author":"LA Abdulkhaleq","year":"2018","journal-title":"Vet World"},{"key":"pone.0292756.ref035","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.psychres.2017.11.086","article-title":"Total and Differential White Blood Cell Counts and Hemodynamic Parameters in First-Episode Psychosis","volume":"260","author":"G Moody","year":"2018","journal-title":"Psychiatry Res"},{"key":"pone.0292756.ref036","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/acps.13140","article-title":"Meta-Analysis of Total and Differential White Blood Cell Counts in Schizophrenia","volume":"142","author":"AJ Jackson","year":"2020","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"pone.0292756.ref037","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.schres.2010.02.1028","article-title":"Higher White Blood Cell Counts Are Associated with an Increased Risk for Metabolic Syndrome and More Severe Psychopathology in Non-Diabetic Patients with Schizophrenia","volume":"118","author":"X Fan","year":"2010","journal-title":"Schizophr Res"},{"key":"pone.0292756.ref038","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.plefa.2012.05.005","article-title":"Clinical and Biochemical Validation of Two Endophenotypes of Schizophrenia Defined by Levels of Polyunsaturated Fatty Acids in Red Blood Cells","volume":"87","author":"H Bentsen","year":"2012","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"pone.0292756.ref039","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/0269881120981392","article-title":"Effects of Omega-3 Polyunsaturated Fatty Acids Supplements on Psychopathology and Metabolic Parameters in Schizophrenia: A Meta-Analysis of Randomized Controlled Trials","volume":"35","author":"KK Goh","year":"2021","journal-title":"J Psychopharmacol"},{"key":"pone.0292756.ref040","first-page":"1","article-title":"Reduced Erythrocyte Membrane Polyunsaturated Fatty Acid Levels Indicate Diminished Treatment Response in Patients with Multi- versus First-Episode Schizophrenia","volume":"8","author":"N Li","year":"2022","journal-title":"Schizophr"},{"key":"pone.0292756.ref041","doi-asserted-by":"crossref","first-page":"728990","DOI":"10.3389\/fpsyt.2021.728990","article-title":"Is Elevated Neutrophil Count and Neutrophil-to-Lymphocyte Ratio a Cause or Consequence of Schizophrenia?\u2014A Scoping Review","volume":"12","author":"AA Sandberg","year":"2021","journal-title":"Front Psychiatry"},{"key":"pone.0292756.ref042","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/schbul\/sby113","article-title":"Neutrophil Count Is Associated With Reduced Gray Matter and Enlarged Ventricles in First-Episode Psychosis","volume":"45","author":"C N\u00fa\u00f1ez","year":"2019","journal-title":"Schizophrenia Bulletin"},{"key":"pone.0292756.ref043","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1046\/j.1523-1755.2003.00044.x","article-title":"AOPP-Induced Activation of Human Neutrophil and Monocyte Oxidative Metabolism: A Potential Target for N-Acetylcysteine Treatment in Dialysis Patients","volume":"64","author":"V Witko-Sarsat","year":"2003","journal-title":"Kidney Int"},{"key":"pone.0292756.ref044","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1017\/S1461145710001653","article-title":"An Activated Set Point of T-Cell and Monocyte Inflammatory Networks in Recent-Onset Schizophrenia Patients Involves Both pro- and Anti-Inflammatory Forces","volume":"14","author":"RC Drexhage","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"pone.0292756.ref045","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/pu.30740","article-title":"Eosinophilia Associated with Clozapine Therapy","volume":"32","author":"YWF Lam","year":"2021","journal-title":"The Brown University Psychopharmacology Update"},{"key":"pone.0292756.ref046","doi-asserted-by":"crossref","first-page":"101026","DOI":"10.1016\/j.mam.2021.101026","article-title":"Molecular Mechanisms of Oxidative Stress in Asthma","volume":"85","author":"C Michaeloudes","year":"2022","journal-title":"Mol Aspects Med"},{"key":"pone.0292756.ref047","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbi.2020.09.011","article-title":"Inflammatory and Cardiometabolic Markers at Presentation with First-episode Psychosis and Long-Term Clinical Outcomes: A Longitudinal Study Using Electronic Health Records","volume":"91","author":"EF Osimo","year":"2021","journal-title":"Brain Behav Immun"},{"key":"pone.0292756.ref048","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cell.2016.10.042","article-title":"The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease","volume":"167","author":"WJ Astle","year":"2016","journal-title":"Cell"},{"key":"pone.0292756.ref049","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0920-9964(99)00218-2","article-title":"Increased Frequency of Activated Lymphocytes in the Cerebrospinal Fluid of Patients with Acute Schizophrenia","volume":"49","author":"HV Nikkil\u00e4","year":"2001","journal-title":"Schizophr Res"},{"key":"pone.0292756.ref050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/15622975.2020.1761033","article-title":"High-Lethality of Suicide Attempts Associated with Platelet to Lymphocyte Ratio and Mean Platelet Volume in Psychiatric Inpatient Setting","volume":"22","author":"A Aguglia","year":"2021","journal-title":"World J Biol Psychiatry"},{"key":"pone.0292756.ref051","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/08039488.2018.1441906","article-title":"Thiol\/Disulphide Homeostasis in Schizophrenia Patients with Positive Symptoms","volume":"72","author":"K \u00dcnal","year":"2018","journal-title":"Nordic Journal of Psychiatry"},{"key":"pone.0292756.ref052","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.clinbiochem.2014.09.026","article-title":"A Novel and Automated Assay for Thiol\/Disulphide Homeostasis","volume":"47","author":"O Erel","year":"2014","journal-title":"Clinical Biochemistry"},{"key":"pone.0292756.ref053","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1080\/13813455.2020.1773505","article-title":"Prognostic Value of Thiol\/Disulfide Homeostasis in Symptomatic Patients with Heart Failure","volume":"127","author":"HM Caliskan","year":"2021","journal-title":"Arch Physiol Biochem"},{"key":"pone.0292756.ref054","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s10072-021-05331-x","article-title":"Evaluation of IL-10, IFN-\u03b3, and Thiol\u2013Disulfide Homeostasis in Patients with Drug-Resistant Epilepsy","volume":"43","author":"M Kocat\u00fcrk","year":"2022","journal-title":"Neurol Sci"},{"key":"pone.0292756.ref055","doi-asserted-by":"crossref","first-page":"e8340450","DOI":"10.1155\/2022\/8340450","article-title":"Evaluation of Thiol\/Disulfide Homeostasis in Bronchiectasis","volume":"2022","author":"S Ozyurt","year":"2022","journal-title":"Canadian Respiratory Journal"},{"key":"pone.0292756.ref056","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.3390\/jcm11061507","article-title":"Thiol-Disulfide Homeostasis in Skin Diseases","volume":"11","author":"SR Georgescu","year":"2022","journal-title":"Journal of Clinical Medicine"},{"key":"pone.0292756.ref057","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.psychres.2017.02.016","article-title":"Thiol\/Disulfide Homeostasis in Untreated Schizophrenia Patients","volume":"251","author":"C Topcuoglu","year":"2017","journal-title":"Psychiatry Research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0292756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T17:33:22Z","timestamp":1697132002000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0292756"}},"subtitle":[],"editor":[{"given":"Colin","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":57,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0292756","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]}}}