{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:20:24Z","timestamp":1747196424452,"version":"3.40.5"},"reference-count":13,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To identify how the inner retinal layer and microvasculature change with age by analyzing the relationships of ganglion cell-inner plexiform layer (GC-IPL) thickness, vessel density (VD), and the ratio of these measurements with age in healthy eyes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Participants were divided into five groups according to age. The GC-IPL thickness, VD, and GC-IPL\/VD ratio were compared among the groups. Linear regression analyses were performed to identify relationships of GC-IPL\/VD ratio with age.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The average GC-IPL thicknesses were 84.84 \u00b1 5.28, 84.22 \u00b1 5.30, 85.20 \u00b1 6.29, 83.29 \u00b1 7.06, and 82.26 \u00b1 5.62 \u03bcm in the 20s, 30s, 40s, 50s, and 60s age groups, respectively. The VDs were 20.94 \u00b1 1.50, 21.06 \u00b1 1.50, 20.99 \u00b1 1.03, 20.71 \u00b1 0.93, and 19.74 \u00b1 1.73 mm<jats:sup>-1<\/jats:sup> in the 20s, 30s, 40s, 50s, and 60s age groups, respectively. The GC-IPL\/VD ratio was 4.05, 4.00, 4.06, 4.02, and 4.17 in each group, respectively, and the ratio of the 60s age group was significantly higher than that of other groups. In linear regression analyses, the GC-IPL\/VD ratio was significantly associated with age in the participants aged \u2265 50 years (B = 0.014, P = 0.013), whereas it was not in the participants aged &lt; 50 years (B = 0.003, P = 0.434).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>GC-IPL thickness and macular VD showed a tendency to decrease beginning in the 50s age group and the GC-IPL\/VD ratio was significantly increased in the 60s age group. Additionally, the GC-IPL\/VD ratio was positively associated with age in subjects aged \u2265 50 years, which implies a more pronounced decline over time in VD rather than GC-IPL thickness.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0292942","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T17:33:22Z","timestamp":1697650402000},"page":"e0292942","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analyses of the ratio of ganglion cell-inner plexiform layer thickness to vessel density according to age in healthy 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differs according to the location of visual field loss","volume":"121","author":"H-Y Shin","year":"2014","journal-title":"Ophthalmology"},{"issue":"1","key":"pone.0292942.ref013","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/brain\/113.1.27","article-title":"Cerebral blood flow, blood volume and oxygen utilization: normal values and effect of age","volume":"113","author":"K Leenders","year":"1990","journal-title":"Brain"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0292942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T17:33:30Z","timestamp":1697650410000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0292942"}},"subtitle":[],"editor":[{"given":"Osamudiamen 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