{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:01:45Z","timestamp":1773176505809,"version":"3.50.1"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Arch McNamara Foundation"},{"name":"Macula Society Young Investigator Award"},{"name":"Retina Society Research Award"},{"name":"Alcon Research Institute Young Investigator Award"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To assess public awareness, interest, and concerns regarding Vuity (1.25% pilocarpine hydrochloride ophthalmic solution), an eye drop for the treatment of presbyopia, based on Google Trends.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We used Google Trends that provides a relative search volume for queried terms, to evaluate searches for Vuity from June 30, 2021, to June 30, 2022, in the United States. The data for this study were downloaded on June 30, 2022. Main outcome measures were changes in relative search volumes for the terms \u201cVuity,\u201d \u201cEye drops for reading,\u201d \u201cEye drops for near vision,\u201d \u201cPresbyopia,\u201d \u201cPilocarpine,\u201d and related popular search terms, such as \u201cVuity side effects,\u201d and \u201cVuity retinal detachment\u201d.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Since the approval of Vuity on October 29, 2021, notable increases in the relative search volumes occurred for Vuity in October 2021, December 2021, and from March to April 2022, which coincided with its approval, availability, and subsequent direct-to-consumer advertising based on positive results of clinical trials. The direct-to-consumer advertising had the greatest impact on the search volume for Vuity. Specific interests included Vuity cost, where to buy it, and its side effects. Retinal detachment was the most highly searched Vuity side effect. Geographic variation was evident, with the relative search volumes highest for \u201cVuity\u201d in Wyoming, followed by North Dakota.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Google Trends is a useful tool for monitoring increases in public interest in Vuity for presbyopia. Public concerns regarding side effects warrant further real-world investigations of the causal relationship between Vuity and retinal detachment.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0293066","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T17:26:01Z","timestamp":1698341161000},"page":"e0293066","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Google Search Trends to assess public interest in and concern about Vuity for treating presbyopia"],"prefix":"10.1371","volume":"18","author":[{"given":"Taku","family":"Wakabayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana A.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Abishek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayanth","family":"Sridhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3649-4746","authenticated-orcid":true,"given":"David","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Deaner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Yonekawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-3245","authenticated-orcid":true,"given":"Ajay E.","family":"Kuriyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"pone.0293066.ref001","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.ophtha.2018.04.013","article-title":"Global Prevalence of Presbyopia and Vision Impairment from Uncorrected Presbyopia Systematic Review, Meta-analysis, and Modelling","volume":"125","author":"TR Fricke","year":"2018","journal-title":"Ophthalmology"},{"key":"pone.0293066.ref002","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1001\/jamaophthalmol.2022.0059","article-title":"Safety and Efficacy of AGN-190584 in Individuals With Presbyopia","volume":"140","author":"GO Waring","year":"2022","journal-title":"Jama Ophthalmol"},{"key":"pone.0293066.ref003","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.3390\/jcm11051385","article-title":"Pharmacological Treatment in Presbyopia","volume":"11","author":"A Grzybowski","year":"2022","journal-title":"J Clin Medicine"},{"key":"pone.0293066.ref004","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0002-9394(14)75255-9","article-title":"Retinal Detachment and Miotic Therapy","volume":"85","author":"LG Pape","year":"1978","journal-title":"Am J Ophthalmol"},{"key":"pone.0293066.ref005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0161-6420(79)35529-4","article-title":"Retinal Detachments and Topical Ocular Miotics","volume":"86","author":"H Beasley","year":"1979","journal-title":"Ophthalmology"},{"key":"pone.0293066.ref006","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0161-6420(82)34866-6","article-title":"Side Effects and Ways to Avoid Them","volume":"89","author":"TJ Zimmerman","year":"1982","journal-title":"Ophthalmology"},{"key":"pone.0293066.ref007","article-title":"Retinal Detachments Associated with Topical Pilocarpine Use for Presbyopia Pilocarpine-Associated Retinal Detachments","author":"H Al-khersan","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"pone.0293066.ref008","doi-asserted-by":"crossref","DOI":"10.1097\/ICB.0000000000001309","article-title":"Rhegmatogenous Retinal Detachment Following Initiation of Pilocarpine Hydrochloride Ophthalmic Solution 1.25% for Treatment of Presbyopia","author":"EA Eton","year":"2022","journal-title":"Retin Cases Brief Reports"},{"key":"pone.0293066.ref009","unstructured":"Search Engine Market Share in United State of America. 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