{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T09:02:46Z","timestamp":1775984566958,"version":"3.50.1"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DEB2032632"],"award-info":[{"award-number":["DEB2032632"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DEB2032632"],"award-info":[{"award-number":["DEB2032632"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DEB203263"],"award-info":[{"award-number":["DEB203263"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Materials Application Research Center"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    PAX6 is well known as a transcription factor that drives eye development in animals as widely divergent as flies and mammals. In addition to its localization in eyes, PAX6 expression has been reported in the central nervous system, the pancreas, testes, Merkel cells, nasal epithelium, developing cells of the inner ear, and embryonic submandibular salivary gland. Here we show that PAX6 also appears to be present in the mechanosensory neuromasts of the lateral line system in paedomorphic salamanders of the genus\n                    <jats:italic>Eurycea<\/jats:italic>\n                    . Using immunohistochemistry and confocal microscopy to examine a limited number of larvae of two species, listed by the United States of America\u2019s federal government as threatened (\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>nana<\/jats:italic>\n                    ) or endangered (\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>rathbuni<\/jats:italic>\n                    ), we found that anti-PAX6 antibody labeled structures that were extranuclear, and labeling was most intense in the apical appendages of the hair cells of the neuromast. This extranuclear localization raises the possibility of an as yet undescribed function for PAX6 as a cytoskeleton-associated protein.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0293163","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T13:40:46Z","timestamp":1725025246000},"page":"e0293163","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["PAX6 protein in neuromasts of the lateral line system of salamanders (Eurycea)"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8258-8646","authenticated-orcid":true,"given":"Brittany A.","family":"Dobbins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben U.","family":"Tovar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Braden J.","family":"Oddo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian G.","family":"Teague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7721-5083","authenticated-orcid":true,"given":"Nisa A.","family":"Sindhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0123-2247","authenticated-orcid":true,"given":"Thomas J.","family":"Devitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Hillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9551-9184","authenticated-orcid":true,"given":"Dana M.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"issue":"3","key":"pone.0293163.ref001","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3390\/cells12030400","article-title":"PAX6 expression patterns in the adult human limbal stem cell niche","volume":"12","author":"N Polisetti","year":"2023","journal-title":"Cells"},{"key":"pone.0293163.ref002","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00439-020-02212-9","article-title":"Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease","volume":"140","author":"B Thompson","year":"2021","journal-title":"Hum Genet"},{"issue":"5","key":"pone.0293163.ref003","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1387\/ijdb.113406ip","article-title":"Regulation of Merkel cell development by Pax6","volume":"56","author":"I Parisi","year":"2012","journal-title":"Int. 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