{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:57:37Z","timestamp":1793275057941,"version":"4.5.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Asian Regional Special Cooperation Fund of National Health Commission of the People\u2019s Republic of China","award":["BLXM01"],"award-info":[{"award-number":["BLXM01"]}]},{"name":"the Innovative Engineering Program sponsored by Chinese Academy of Medical Sciences","award":["2020-I2M-2-015"],"award-info":[{"award-number":["2020-I2M-2-015"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Men who have sex with men (MSM) are at high risk of HIV acquisition. Long-acting injectable-pre-exposure prophylaxis (LAI-PrEP), requiring less frequent dosing, is being studied as an alternative method to daily oral HIV PrEP. With the addition of this potential new prevention method, it expands the scope for a wider user choice and is expected to increase the acceptability and uptake of HIV prevention measures. The aim of our study was to explore the willingness to use LAI-PrEP and associated influential factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Participants were recruited from December 2020 to March 2021 through banner advertisements on web- and mobile app-based platforms on Blued, a large gay Chinese social media platform. MSM in our cross-sectional study was HIV-negative and currently lived in mainland China. Participants were asked about their willingness to use LAI-PrEP and reasons why they might be or not be willing to use LAI-PrEP. Multivariable logistic regression was used to analyze the factors associated with the willingness to use LAI-PrEP.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>In total, 969 participants met the inclusion criteria and finished the survey. Nearly twenty percent (19.5%) of participants had never tested for HIV; 66.8% of MSM had multiple male partners; and 51.6% of MSM engaged in condomless sex with their partner. About three-fifths (66.3%) of MSM were aware of PrEP, and only 3.9% of MSM had used PrEP before. The willingness to use LAI-PrEP among MSM was 74.0% (95% CI: 71.4%-76.6%). MSM with higher education levels were less likely to show a willingness to use LAI-PrEP (AOR = 0.56, 95%CI: 0.38\u20130.84). Participants who had a history of HIV test (AOR = 1.68, 95%CI: 1.11\u20132.55), were willing to use daily oral PrEP (AOR = 10.64, 95%CI:7.43\u201315.21), had multiple male sexual partners (AOR = 1.33, 95%CI:0.93\u20131.90), who used rush popper(AOR = 1.49, 95%CI:1.05\u20132.13), and who were aware of PEP (AOR = 1.66, 95%CI: 1.02\u20132.70) were more likely to show willingness to use LAI-PrEP.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In our study, MSM had quite high awareness but low uptake of PrEP. As LAI-PrEP is expected to be approved for use in China in the future, our study of MSM highlights the need for key population-focused education programs about PrEP and healthy sexual behavior. This study also provides some evidence for LAI-PrEP use among the Chinese MSM population in the future.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0293297","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T17:48:48Z","timestamp":1697737728000},"page":"e0293297","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Willingness to use long-acting injectable PrEP among HIV-negative\/unknown men who have sex with men in mainland China: A cross-sectional online survey"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5348-3776","authenticated-orcid":true,"given":"Jiaqi","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiman","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4216-2142","authenticated-orcid":true,"given":"Xiaoyou","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"pone.0293297.ref001","first-page":"6682932","article-title":"Awareness of and preferences for preexposure prophylaxis (PrEP) among MSM at high risk of HIV infection in southern China: findings from the T2T study.","volume":"2021","author":"W Chen","year":"2021","journal-title":"Biomed Res Int"},{"issue":"3","key":"pone.0293297.ref002","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10461-020-03023-9","article-title":"Interest in long-acting injectable pre-exposure prophylaxis (LAI PrEP) among women in the women\u2019s interagency HIV study (WIHS): a qualitative study across six cities in the United States.","volume":"25","author":"MM Philbin","year":"2021","journal-title":"AIDS Behav"},{"issue":"48","key":"pone.0293297.ref003","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.46234\/ccdcw2021.249","article-title":"Research progress in the epidemiology of HIV\/AIDS","volume":"3","author":"N. 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