{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:24:23Z","timestamp":1793730263677,"version":"4.6.1"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Malaria in pregnancy is a global public health problem with the majority of its impact seen in sub-Saharan Africa. Pregnant women with malaria infection are at risk of adverse maternal outcomes. In Ghana, malaria in pregnancy accounts for about 17.6% of outpatient department attendance. Ashanti region is among the three regions with the highest malaria prevalence in pregnancy, particularly in the Ejisu Municipality. The study, therefore, assessed the prevalence and determinants of malaria infection among pregnant women seeking antenatal care at the Ejisu Government Hospital in Ghana.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A cross-sectional study design with a convenience sampling technique was used to select 140 respondents for the study. Primary data such as age and residence of respondents were collected using a questionnaire and secondary data such as gestational age and Sulphadoxine Pyrimethamine (SP) administration were collected from clients\u2019 maternal health record booklet. Bivariate and multivariate logistic regression analysis were used to assess the association between the malaria infection and the independent variables, and a p-value of &lt; 0.05 was considered statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The overall prevalence of malaria in pregnancy was 24 (17.1%). Most of the respondents had received counselling and health education 126 (90%), two or more doses of SP 95 (87.2%), Insecticide Treated Net (ITN) 99 (70.7%) and were sleeping under ITN 104 (74.3%). Multivariate logistic regression analysis showed a statistically significant association between malaria infection and sleeping under ITN (AOR = 0.05; 95% CI = 0.01\u20130.28, p&lt; .001), the use of insecticide mosquito spray (AOR = 0.27; 95% CI = 0.09\u20130.84, p = .045) and reason for not using ITN due to the use of other preventive measures (AOR = 0.06; 95% CI = 0.01\u20130.61, p = .017).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>There was a high prevalence of malaria infection among study respondents despite the high usage of preventive measures for malaria in this study. It is therefore crucial that stakeholders in malaria control identify effective strategies to curb malaria transmission globally.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0293420","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T17:56:09Z","timestamp":1698688569000},"page":"e0293420","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence and determinants of malaria infection among pregnant women attending antenatal clinic in Ejisu government hospital in Ghana: A cross-sectional study"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-0256","authenticated-orcid":true,"given":"Catherine Kroamah","family":"Dwumfour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria Bubunyo","family":"Bam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-2749","authenticated-orcid":true,"given":"Lydia Boampong","family":"Owusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collins Atta","family":"Poku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhoda Dewe","family":"Kpabitey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Aboagye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amshariatu Suntaa","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"pone.0293420.ref001","unstructured":"World Health Organization. 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Ghana Health Service 2016 Annual Report, (June), 1\u2013129. https:\/\/www.ghanahealthservice.org\/downloads\/GHS_ANNUAL_REPORT_2016_n.pdf. 2017."},{"key":"pone.0293420.ref023","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1371\/journal.pmed.0040107","article-title":"Insecticide-Treated Nets for the Prevention of Malaria in Pregnancy: A Systematic Review of Randomised Controlled Trials","volume":"4","author":"C Gamble","year":"2007","journal-title":"PLoS Med"},{"key":"pone.0293420.ref024","article-title":"Effectiveness of intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) in Ghana","author":"DK Dosoo","year":"2021","journal-title":"BMJ Glob Heal"},{"key":"pone.0293420.ref025","article-title":"Intermittent Preventive Treatment of Malaria in Pregnancy: Assessment of the Sulfadoxine-Pyrimethamine Three-Dose Policy on Birth Outcomes in Rural Northern Ghana","author":"F Anto","year":"2019","journal-title":"J Trop Med"},{"key":"pone.0293420.ref026","unstructured":"World Health Organization. World malaria report 2014 [Internet]. World Heal. Organ. 2014 [cited 2023 Aug 29]. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789241564830."},{"key":"pone.0293420.ref027","article-title":"Intermittent preventive treatment of pregnant women in Kintampo area of Ghana with sulphadoxine-pyrimethamine (SP): Trends spanning 2011 and 2015","author":"FB Oppong","year":"2019","journal-title":"BMJ Open. BMJ Publishing Group"},{"key":"pone.0293420.ref028","doi-asserted-by":"crossref","first-page":"e00222","DOI":"10.1016\/j.parepi.2021.e00222","article-title":"Uptake challenges of intermittent preventive malaria therapy among pregnant women and their health care providers in the Upper West Region of Ghana: A mixed-methods study","volume":"15","author":"F Dun-Dery","year":"2021","journal-title":"Parasite Epidemiol Control"},{"key":"pone.0293420.ref029","unstructured":"Ghana Statistical Service (GSS), ICF. Ghana Demographic and Health Survey 2022: Key Indicators Report. Accra, Ghana, and Rockville, Maryland, USA:; 2023."},{"key":"pone.0293420.ref030","unstructured":"Ministry of Local Government, Development D and rural. Ejisu Municipal Assembly Composite Annual Action Plan for 2023. Kumasi; 2022."},{"key":"pone.0293420.ref031","unstructured":"Ejisu MA. Composite Budget for 2023\u20132026: Programme Based Budget Estimates for 2023. Kumasi; 2022."},{"key":"pone.0293420.ref032","unstructured":"Ejisu Juaben District Assembly. Ejisu Juaben District Assembly, 2017 Annual Progress Report. Kumasi; 2017."},{"key":"pone.0293420.ref033","first-page":"14","article-title":"Calculating the Sample Size in Quantitative Studies","author":"GP Adhikari","year":"2021","journal-title":"Sch J"},{"key":"pone.0293420.ref034","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s12874-019-0881-y","article-title":"Why do participants drop-out: findings from a prospective pediatric cohort for fever surveillance established at Vellore, southern India","volume":"19","author":"KN Sindhu","year":"2019","journal-title":"BMC Med Res Methodol"},{"key":"pone.0293420.ref035","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1086\/268253","article-title":"Nonresponse, Sample Size, and the Allocation of Resources","volume":"39","author":"I Wayne","year":"1975","journal-title":"Public Opin Q"},{"key":"pone.0293420.ref036","first-page":"1109","article-title":"Prevalence of Malaria and Frequency of Severe Symptoms among Pregnant Women in Pawe Hospital, North Western Ethiopia","volume":"5","author":"GH Geleta","year":"2017","journal-title":"Ann Clin Pathol"},{"key":"pone.0293420.ref037","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-014-0631-z","article-title":"Prevalence and risk factors for Plasmodium falciparum malaria in pregnant women attending antenatal clinic in Bobo-Dioulasso (Burkina Faso)","volume":"14","author":"M Cisse","year":"2014","journal-title":"BMC Infect Dis"},{"key":"pone.0293420.ref038","first-page":"67","article-title":"Prevalence and Possible Risk Factors of Malaria among Pregnant Women Attending To Antenatal Care at Umtalha Health Centre in Gezira State -Sudan","volume":"12","author":"EAM Abdalla","year":"2017","journal-title":"IOSR J Pharm Biol Sci"},{"key":"pone.0293420.ref039","first-page":"21","article-title":"Prevalenceof malaria and anaemiaamong pregnant women attending Antenatal Care Clinic in the Hohoe Municipality of Ghana","volume":"7","author":"M Kweku","year":"2017","journal-title":"Int J Nurs Didact"},{"key":"pone.0293420.ref040","unstructured":"Ministry of Health (MOH), Ghana Health Service (GHS), National Malaria Control Programme (NMCP). Guidelines for Case Management of Malaria in Ghana. 4th ed. Accra: Accra: MOH, GHS and NMCP.; 2020."},{"key":"pone.0293420.ref041","doi-asserted-by":"crossref","DOI":"10.30875\/7e6f8c91-en","volume-title":"World Malaria Report 2019","author":"World Health Organization","year":"2019"},{"key":"pone.0293420.ref042","doi-asserted-by":"crossref","first-page":"27","DOI":"10.12688\/aasopenres.12979.1","article-title":"Impact of malaria on haematological parameters of urban, peri-urban and rural patients in the Ashanti region of Ghana: a cross-sectional study","volume":"2","author":"A-H Mutala","year":"2019","journal-title":"AAS Open Res"},{"key":"pone.0293420.ref043","doi-asserted-by":"crossref","first-page":"879","DOI":"10.4269\/ajtmh.20-1533","article-title":"Importance of Community-Level Interventions During the COVID-19 Pandemic: Lessons from Sub-Saharan Africa","volume":"105","author":"A Owoyemi","year":"2021","journal-title":"Am J Trop Med 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