{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T01:37:29Z","timestamp":1776044249206,"version":"3.50.1"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K16147"],"award-info":[{"award-number":["19K16147"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25251026"],"award-info":[{"award-number":["25251026"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02447"],"award-info":[{"award-number":["18H02447"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K15128"],"award-info":[{"award-number":["22K15128"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The <jats:italic>zinc finger and BTB domain-containing 11<\/jats:italic> gene (<jats:italic>zbtb11<\/jats:italic>) is expressed in the <jats:italic>Xenopus<\/jats:italic> anterior neuroectoderm, but the molecular nature of the Zbtb11 protein during embryonic development remains to be elucidated. Here, we show the role of Zbtb11 in anterior patterning of the neuroectoderm and the cooperative action with the transcription factor Otx2. Both overexpression and knockdown of <jats:italic>zbtb11<\/jats:italic> caused similar phenotypes: expanded expression of the posterior gene <jats:italic>gbx2<\/jats:italic> in the neural plate, and later microcephaly with reduced eyes, suggesting that a proper level of <jats:italic>zbtb11<\/jats:italic> expression is necessary for normal patterning of the neuroectoderm, including eye formation. Co-immunoprecipitation assays showed that Zbtb11 formed a complex with itself and with a phosphomimetic and repressive form of Otx2, suggesting that Zbtb11 forms a dimer or oligomer and interacts with Otx2 in a phosphorylation-dependent manner. Reporter analysis further showed that Zbtb11 enhanced the activity of the phosphomimetic Otx2 to repress a silencer element of the posterior gene <jats:italic>meis3<\/jats:italic>. These data suggest that Zbtb11 coordinates with phosphorylated Otx2 to specify the anterior neuroectoderm by repressing posterior genes.<\/jats:p>","DOI":"10.1371\/journal.pone.0293852","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T19:45:36Z","timestamp":1722455136000},"page":"e0293852","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Zbtb11 interacts with Otx2 and patterns the anterior neuroectoderm in Xenopus"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8666-9327","authenticated-orcid":true,"given":"Yumeko","family":"Satou-Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-0837","authenticated-orcid":true,"given":"Yoshikazu","family":"Haramoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Asashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Taira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"pone.0293852.ref001","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/35042039","article-title":"The establishment of spemann\u2019s organizer and patterning of the vertebrate embryo","volume":"1","author":"EM De Robertis","year":"2000","journal-title":"Nat Rev Genet"},{"key":"pone.0293852.ref002","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1440-169X.1998.t01-1-00001.x","article-title":"Neural induction in embryos","volume":"40","author":"H Tiedemann","year":"1998","journal-title":"Dev Growth Differ"},{"key":"pone.0293852.ref003","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/dgd.12293","article-title":"Fgf8 signaling for development of the midbrain and hindbrain","volume":"58","author":"H Harada","year":"2016","journal-title":"Dev Growth Differ"},{"key":"pone.0293852.ref004","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1387\/ijdb.092853cv","article-title":"Molecular mechanisms controlling brain development: An overview of neuroepithelial secondary organizers","volume":"54","author":"C Vieira","year":"2010","journal-title":"Int J Dev Biol"},{"key":"pone.0293852.ref005","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1387\/ijdb.052083nt","article-title":"Systematic screening for genes specifically expressed in the anterior neuroectoderm during early Xenopus development","volume":"49","author":"N Takahashi","year":"2005","journal-title":"Int J Dev Biol"},{"key":"pone.0293852.ref006","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-065X.2012.01116.x","article-title":"POK\/ZBTB proteins: An emerging family of proteins that regulate lymphoid development and function","volume":"247","author":"SU Lee","year":"2012","journal-title":"Immunol Rev"},{"key":"pone.0293852.ref007","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/nrc1752","article-title":"A role for kaiso-p120ctn complexes in cancer?","volume":"5","author":"M. 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