{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:49:33Z","timestamp":1793897373416,"version":"4.8.0"},"reference-count":198,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Cardiometabolic risk factors (impaired fasting glucose, abdominal obesity, high blood pressure, dyslipidemia) cluster in children, may predict adult disease burden, and are inadequately characterized in South American children.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>To quantify the burden of cardiometabolic risk factors in South American children (0\u201321 years) and identify knowledge gaps.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We systematically searched PubMed, Google Scholar, and the Latin American and Caribbean Health Sciences Literature via Virtual Health Library from 2000\u20132021 in any language. Two independent reviewers screened and extracted all data.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>179 studies of 2,181 screened were included representing 10 countries (n = 2,975,261). 12.2% of South American children experienced obesity, 21.9% elevated waist circumference, 3.0% elevated fasting glucose, 18.1% high triglycerides, 29.6% low HDL cholesterol, and 8.6% high blood pressure. Cardiometabolic risk factor definitions varied widely. Chile exhibited the highest prevalence of obesity\/overweight, low HDL, and impaired fasting glucose. Ecuador exhibited the highest prevalence of elevated blood pressure. Rural setting (vs. urban or mixed) and indigenous origin protected against most cardiometabolic risk factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>South American children experience high rates of obesity, overweight, and dyslipidemia. International consensus on cardiometabolic risk factor definitions for children will lead to improved diagnosis of cardiometabolic risk factors in this population, and future research should ensure inclusion of unreported countries and increased representation of indigenous populations.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0293865","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:39:00Z","timestamp":1700678340000},"page":"e0293865","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cardiometabolic risk factors in South American children: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-9025","authenticated-orcid":true,"given":"Carolyn M. 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Omer","year":"2020","journal-title":"Advances in Obesity, Weight Management & Control"},{"key":"pone.0293865.ref004","first-page":"140","article-title":"The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering","author":"SN Magge","year":"2017","journal-title":"PEDIATRICS"},{"key":"pone.0293865.ref005","article-title":"Prevalence of a Metabolic Syndrome Phenotype in Adolescents Findings From the Third National Health and Nutrition Examination Survey, 1988\u20131994.","author":"S Cook","year":"2003","journal-title":"Arch Pediatric Adolescent Med"},{"issue":"16","key":"pone.0293865.ref006","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/01.CIR.0000145117.40114.C7","article-title":"Prevalence of the metabolic syndrome in American adolescents: Findings from the Third National Health and Nutrition Examination Survey","volume":"110","author":"SD De Ferranti","year":"2004","journal-title":"Circulation"},{"issue":"2","key":"pone.0293865.ref007","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jpeds.2007.07.056","article-title":"Defining the Metabolic Syndrome in Children and Adolescents: Will the Real Definition Please Stand Up","volume":"152","author":"ES Ford","year":"2008","journal-title":"Journal of Pediatrics"},{"issue":"1","key":"pone.0293865.ref008","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1016\/S2214-109X(19)30484-X","article-title":"Trends in cardiometabolic risk factors in the Americas between 1980 and 2014: A pooled analysis of population-based surveys.","volume":"8","author":"JJ Miranda","year":"2020","journal-title":"The Lancet Global Health"},{"issue":"2","key":"pone.0293865.ref009","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1467-789x.2001.00029.x","article-title":"Obesity prevalence and trends in Latin-American countries.","volume":"2","author":"C Filozof","year":"2001","journal-title":"Obesity Reviews"},{"key":"pone.0293865.ref010","unstructured":"PRISMA [Internet]. [cited 2020 May 5]. Available from: http:\/\/www.prisma-statement.org\/PRISMAStatement\/FlowDiagram"},{"issue":"3","key":"pone.0293865.ref011","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1524-475X.2004.04006.x","article-title":"A process for systematically reviewing the literature: Providing the research evidence for public health nursing interventions","volume":"1","author":"BH Thomas","year":"2004","journal-title":"Worldviews on Evidence-Based Nursing"},{"issue":"4","key":"pone.0293865.ref012","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1177\/156482651303400404","article-title":"Prevalence of overweight and obesity among 6- to 9-year-old schoolchildren in cuenca, ecuador: Relationship with physical activity, poverty, and eating habits.","volume":"34","author":"V Abril","year":"2013","journal-title":"Food and Nutrition Bulletin"},{"issue":"1","key":"pone.0293865.ref013","first-page":"39","article-title":"Blood pressure and family history of hypertension in children from Santiago, Chile.","volume":"137","author":"MI Aglony","year":"2009","journal-title":"Revista m\u00e9dica de Chile [Internet]."},{"key":"pone.0293865.ref014","article-title":"Deterimaci\u00f3n de la Prevalencia del Riesgo Cardiovascular Utilizando La Clasificaci\u00f3n Internacional De La Circunferencia De La Cintura Por Percentiles, En Adolescentes De 13 a 18 A\u00f1os De La Sierra Del Ecuador","author":"FE Aguilar Salinas","year":"2016"},{"issue":"1","key":"pone.0293865.ref015","first-page":"1","article-title":"U. Association between serum zinc level and hypercholesterolemia and insulin resistance in Brazilian children.","volume":"34","author":"F Albuquerque","year":"2018","journal-title":"Cadernos de Saude Publica [Internet]"},{"issue":"2","key":"pone.0293865.ref016","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1740-8709.2010.00267.x","article-title":"The association between self perceptions of psychological well-being and overweight in Brazilian children.","volume":"8","author":"SL Alexius","year":"2012","journal-title":"Maternal and Child Nutrition"},{"issue":"1","key":"pone.0293865.ref017","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2223\/JPED.1862","article-title":"U. Overweight and physical inactivity in children living in favelas in the metropolitan region of Recife, Brazil","volume":"85","author":"J Alves","year":"2009","journal-title":"Journal of Pediatrics [Internet]."},{"issue":"9","key":"pone.0293865.ref018","first-page":"1","article-title":"\u2026U. Waist circumference percentile curves as a screening tool to predict cardiovascular risk factors and metabolic syndrome risk in Brazilian children.","volume":"34","author":"A Andaki","year":"2018","journal-title":"Cadernos de Sa\u00fade P\u00fablica [Internet]."},{"issue":"106","key":"pone.0293865.ref019","article-title":"Physical fitness among urban and rural Ecuadorian adolescents and its association with blood lipids: A cross sectional study","volume":"14","author":"S Andrade","year":"2014","journal-title":"BMC Pediatrics"},{"issue":"188","key":"pone.0293865.ref020","article-title":"Multilevel analysis of factors that influence overweight in children: research in schools enrolled in northern Brazil School Health Program","volume":"20","author":"R Andrade De Medeiros Moreira","year":"2020","journal-title":"BMC Pediatrics [Internet]."},{"issue":"4","key":"pone.0293865.ref021","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1111\/idh.12248","article-title":"Assessment of quality of life, anxiety, socio-economic factors and caries experience in Brazilian children with overweight and obesity","volume":"15","author":"DS Araujo","year":"2017","journal-title":"International Journal of Dental Hygiene"},{"issue":"5","key":"pone.0293865.ref022","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1249\/01.mss.0000488115.80374.95","article-title":"U. Overweight\/obesity In Brazilian Children: Prevalence And Correlates.","volume":"48","author":"T Araujo","year":"2016","journal-title":"Med Sci Sports Exerc [Internet]."},{"issue":"1","key":"pone.0293865.ref023","first-page":"44","article-title":"Condici\u00f3n f\u00edsica, riesgo cardiometab\u00f3lico y frecuencia cardiaca de recuperaci\u00f3n en escolares chilenos","volume":"35","author":"MJ Arias T\u00e9llez","year":"2018","journal-title":"Nutricion Hospitalaria"},{"issue":"1","key":"pone.0293865.ref024","first-page":"96","article-title":"Waist-to-height ratio may be an alternative tool to the body mass index for identifying Colombian adolescents with cardiometabolic risk factors.","volume":"36","author":"JC Aristiz\u00e1bal","year":"2019","journal-title":"Nutricion Hospitalaria"},{"issue":"3","key":"pone.0293865.ref025","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1590\/S1415-52732006000300001","article-title":"Overweight and thinness in 7\u20139 year old children from Florian\u00f3polis, Southern Brazil: a comparison with a French study using a similar protocol.","volume":"19","author":"M Assis","year":"2006","journal-title":"Revista de Nutri\u00e7\u00e1o [Internet]"},{"issue":"1","key":"pone.0293865.ref026","first-page":"85","article-title":"Protective effect of breastfeeding against overweight can be detected as early as the second year of life: a study of children from one of the most socially-deprived areas of Brazil","volume":"33","author":"M Assun\u00e7\u00e3o","year":"2015","journal-title":"Journal of Health Population Nutrition [Internet]."},{"key":"pone.0293865.ref027","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.dsx.2017.03.024","article-title":"Metabolic syndrome and atherogenic indices in school children: A worrying panorama in Brazil.","volume":"11","author":"SM Barbalho","year":"2017","journal-title":"Diabetes and Metabolic Syndrome: Clinical Research and Reviews"},{"key":"pone.0293865.ref028","first-page":"1435","article-title":"Normal plasma insulin and HOMA values among Chilean children and adolescents.","volume":"139","author":"S Barja","year":"2011","journal-title":"Rev Med Chile [Internet]"},{"issue":"6","key":"pone.0293865.ref029","first-page":"278","article-title":"Prevalencia de obesidad en ni\u00f1os de Juiz de Fora, Brasil [Internet].","volume":"7070","author":"M Barros Costa","year":"2003","journal-title":"Revista Mexicana de Pediatr\u00eda"},{"issue":"2","key":"pone.0293865.ref030","first-page":"58","article-title":"Obesity in children and adolescents, as measured by BMI and ideal weight: case educational institutions in Caracas, Venezuela.","volume":"3","author":"G. Bauce","year":"2018","journal-title":"MOJ Biology and Medicine [Internet]."},{"issue":"1","key":"pone.0293865.ref031","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ajhb.20580","article-title":"Fatness and overweight in Amerindian women and children from riverine Amerindian communities of the Beni River (Bolivian Amazon).","volume":"19","author":"E B\u00e9n\u00e9fice","year":"2007","journal-title":"American Journal of Human Biology [Internet]."},{"issue":"2","key":"pone.0293865.ref032","doi-asserted-by":"crossref","first-page":"49","DOI":"10.9790\/1959-0602014954","article-title":"Relationship of Waist Circumference with Lipid and Glucose Metabolism among Southern Brazilian Children","volume":"6","author":"D Benini","year":"2017","journal-title":"IOSR Journal of Nursing and Health Science"},{"issue":"6","key":"pone.0293865.ref033","first-page":"557","article-title":"Obesity and sedentary lifestyles in four-years old children attending two pre-schools in the city of Rio Grande, Tierra del Fuego, Argentina.","volume":"112","author":"IR Berghtein","year":"2014","journal-title":"Arch Argent Pediatr [Internet]."},{"issue":"2","key":"pone.0293865.ref034","first-page":"269","article-title":"PREVAL\u00caNCIA DE OBESIDADE ABDOMINAL E FATORES ASSOCIADOS EM CRIAN\u00c7AS E ADOLESCENTES DE CASCAVEL-PR, BRASIL ABDOMINAL OBESITY PREVALENCE AND ASSOCIATED FACTORS IN CHILDREN AND ADOLESCENTS IN CASCAVEL-PR STATE, BRAZIL.","volume":"24","author":"J Berria","year":"2013","journal-title":"Revista Educativa Fisica [Internet]."},{"issue":"3","key":"pone.0293865.ref035","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.rchipe.2015.03.001","article-title":"Deficiencia severa de vitamina D en ni\u00f1os de Punta Arenas, Chile: influencia de estado nutricional en la respuesta a suplementaci\u00f3n.","volume":"86","author":"K Brinkmann","year":"2015","journal-title":"Revista Chilena de Pediatr\u00eda [Internet]."},{"key":"pone.0293865.ref036","first-page":"42","article-title":"Dyslipidemia in children with feeding difficulties-a cross-sectional study in a Brazilian reference center.","volume":"46","author":"A Bozzini","year":"2019","journal-title":"Revista Chilena de Nutrici\u00f3n [Internet]"},{"issue":"6","key":"pone.0293865.ref037","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/jech-2014-204992","article-title":"Socioeconomic status is positively associated with measures of adiposity and insulin resistance, but inversely associated with dyslipidaemia in Colombian children.","volume":"69","author":"A Buitrago-Lopez","year":"2015","journal-title":"J Epidemiol Community Health [Internet]."},{"issue":"2","key":"pone.0293865.ref038","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1590\/1984-0462\/;2019;37;2;00007","article-title":"Cardiometabolic risk factors associated with active commuting to school.","volume":"37","author":"MS Burgos","year":"2019","journal-title":"Revista Paulista de Pediatria"},{"issue":"3","key":"pone.0293865.ref039","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1017\/S1368980015001585","article-title":"High cardiometabolic risk in healthy Chilean adolescents: Associations with anthropometric, biological and lifestyle factors.","volume":"19","author":"R Burrows","year":"2015","journal-title":"Public Health Nutrition"},{"issue":"3","key":"pone.0293865.ref040","first-page":"399","article-title":"Estatus ponderal y aptitud cardiorrespiratoria en escolares de la regi\u00f3n central del Per\u00fa.","volume":"30","author":"A Bustamante","year":"2013","journal-title":"Revista Peruana de Medicina Experimental y Salud P\u00fablica [Internet]."},{"issue":"6","key":"pone.0293865.ref041","first-page":"2576","article-title":"La malnutrici\u00f3n por exceso en ni\u00f1os-adolescentes y su impacto en el desarrollo de riesgo cardiometab\u00f3lico y bajos niveles de rendimiento f\u00edsico","volume":"32","author":"F Caama\u00f1o Navarrete","year":"2015","journal-title":"Nutricion Hospitalaria"},{"issue":"4","key":"pone.0293865.ref042","first-page":"445","article-title":"Factors associated with overweight and abdominal obesity in Brazilian school-aged children: a comprehensive approach.","volume":"64","author":"H Caixeta","year":"2020","journal-title":"Archives of Endocrinology and Metabolism [Internet]."},{"issue":"1","key":"pone.0293865.ref043","article-title":"PC81 BREAST FEEDING AND OBESITY IN BRAZILIAN CHILDREN 7\u20139-Y-OLD.","volume":"39","author":"M Calvo","year":"2004","journal-title":"Journal of Pediatric Gastroenterology and Nutrition [Internet]."},{"issue":"5","key":"pone.0293865.ref044","first-page":"531","article-title":"Socioeconomic status and its influence on the prevalence of overweight and obesity among adolescent school children in the city of Fortaleza, Brazil.","volume":"19","author":"L Campos","year":"2006","journal-title":"Revista de Nutri\u00e7\u00e1o [Internet]"},{"key":"pone.0293865.ref045","article-title":"FACTORES RELACIONADOS CON LA PRESENCIA DE RESISTENCIA A LA INSULINA EN ADOLESCENTES URBANOS DE LA CIUDAD DE QUITO.","author":"LA Campoverde R\u00edos","year":"2016","journal-title":"Pontificia Universidad Cat\u00f3lica del Ecuador"},{"issue":"5","key":"pone.0293865.ref046","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.endonu.2012.02.007","article-title":"Waist circumference percentiles in children and adolescents between 6 and 14 years from Santiago, Chile.","volume":"59","author":"F Carolina Avalos","year":"2012","journal-title":"Endocrinologia y Nutricion"},{"issue":"7","key":"pone.0293865.ref047","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.2105\/AJPH.2016.303191","article-title":"Impact of food assistance programs on obesity in mothers and children: A prospective cohort study in Peru.","volume":"106106","author":"RM Carrillo-Larco","year":"2016","journal-title":"American Journal of Public Health. American Public Health Association Inc."},{"key":"pone.0293865.ref048","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijpam.2017.10.002","article-title":"Increase in the prevalence of abdominal obesity in Brazilian school children (2000\u20132015).","volume":"4","author":"D Casagrande","year":"2017","journal-title":"International Journal of Pediatrics and Adolescent Medicine [Internet]."},{"issue":"24","key":"pone.0293865.ref049","article-title":"Cardiometabolic risk factors, metabolic syndrome and pre-diabetes in adolescents in the Sierra region of Ecuador.","volume":"9","author":"SL Casapulla","year":"2017","journal-title":"Diabetology and Metabolic Syndrome"},{"key":"pone.0293865.ref050","first-page":"58","article-title":"Relationship between dietary calcium intake and adiposity in female adolescents [Internet].","volume":"63","author":"J Castro Burbano","year":"2016","journal-title":"Endocrinologia y Nutricion"},{"key":"pone.0293865.ref051","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/ijo.2015.148","article-title":"Serum 25-Hydroxyvitamin D associated with indicators of body fat and insulin resistance in prepubertal chilean children","volume":"40","author":"G Cediel","year":"2016","journal-title":"International Journal of Obesity [Internet]."},{"issue":"1","key":"pone.0293865.ref052","first-page":"62","article-title":"High blood pressure in children and adolescents from urban peripheral areas of la plata, argentina.","volume":"36","author":"MF Cesani","year":"2020","journal-title":"Salud Uninorte"},{"issue":"2","key":"pone.0293865.ref053","first-page":"114","article-title":"Sodium content of meals provided by the national public schools feeding program and its relationship with nutritional status and blood pressure in children from first grade, quillota, chile.","volume":"42","author":"G. B Cobo","year":"2015","journal-title":"Revista chilena de nutrici\u00f3n"},{"issue":"3","key":"pone.0293865.ref054","first-page":"49","article-title":"Body mass index, blood pressure and electrocardiogram for screening in healthy children at Pilar City, Buenos Aires, Argentina, 2012","volume":"29","author":"H Cohen Arazi","year":"2016","journal-title":"Pediatr\u00eda [Internet]."},{"issue":"4","key":"pone.0293865.ref055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093150","article-title":"Low muscle strength is associated with metabolic risk factors in Colombian children: The ACFIES study","volume":"9","author":"DD Cohen","year":"2014","journal-title":"PLoS ONE"},{"issue":"4","key":"pone.0293865.ref056","first-page":"628","article-title":"Neonatal feeding associated with overweight and obesity in children and adolescents of Cuenca, Ecuador.","volume":"17","author":"C Collazo","year":"2018","journal-title":"Revista Habanera de Ciencias M\u00e9dicas [Internet]."},{"issue":"2","key":"pone.0293865.ref057","first-page":"201","article-title":"Prevalence of overweight and its association with the area of residence among 6-year-old children enrolled in public childcare centers in Florian\u00f3polis, Brazil.","volume":"7","author":"A Corso","year":"2004","journal-title":"Revista Brasileira de Epidemiologia [Internet]."},{"key":"pone.0293865.ref058","first-page":"318","article-title":"Obesity is positively associated with dehydroepiandrosterone sulfate concentrations at 7 y in Chilean children of normal birth weight","volume":"97","author":"C Corval\u00e1n","year":"2013","journal-title":"American Journal of Clinic [Internet]."},{"issue":"1","key":"pone.0293865.ref059","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3945\/ajcn.2009.27547","article-title":"Obesity indicators and cardiometabolic status in 4-y-old children","volume":"91","author":"C Corval\u00e1n","year":"2010","journal-title":"American Journal of Clinical Nutrition"},{"key":"pone.0293865.ref060","first-page":"60","article-title":"Prevalence of overweight and obesity in school children of Santos city, Brazil.","volume":"50","author":"R Costa","year":"2006","journal-title":"Arquivos Brasileiros de Endocrinologia & Metabologia [Internet]"},{"issue":"3","key":"pone.0293865.ref061","first-page":"309","article-title":"Nutritional status, knowledge and nutritional behaviour in school children from kindergarten and first grade from three schools identified for child obesity in the zone of valparaiso, Chile","volume":"37","author":"M. M Crovetto","year":"2010","journal-title":"Rev chil nutr [Internet]."},{"issue":"1","key":"pone.0293865.ref062","first-page":"29","article-title":"Behavior problems and overweight in preschool children in southern Brazil.","volume":"66","author":"S Cruz","year":"2017","journal-title":"Jornal Brasileiro de Psiquiatria [Internet]."},{"issue":"4","key":"pone.0293865.ref063","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1590\/S0102-311X2013000800016","article-title":"Time trends (1992\u20132005) in undernutrition and obesity among children under five years of age in Alagoas State, Brazil [Internet].","volume":"29","author":"H da Silva Ferreira","year":"2013","journal-title":"Cadernos de Saude Publica. abr"},{"issue":"6","key":"pone.0293865.ref064","first-page":"1056","article-title":"Factors associated with overweight in children living in the neighbourhoods of an urban area of Brazil. 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Association of body mass index and insulin resistance with metabolic syndrome in Brazilian children.","volume":"93","author":"A Ferreira","year":"2009","journal-title":"Arquivos Brasileiros de Cardiologia [Internet]"},{"key":"pone.0293865.ref076","first-page":"103","article-title":"Cardio-metabolic risk factors in Argentine children. A comparative study. 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EVALUACI\u00d3N NUTRICIONAL DE ESCOLARES RURALES DE LA COMUNA DE TEMUCO, REGI\u00d3N DE LA ARAUCAN\u00cdA.","author":"J Game","year":"2015","journal-title":"Archivos Latinoamericanos de Nutricion [Internet]"},{"key":"pone.0293865.ref081","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.nut.2018.08.019","article-title":"Independent and combined effects of handgrip strength and adherence to a Mediterranean diet on blood pressure in Chilean children.","volume":"60","author":"A Garcia-Hermoso","year":"2019","journal-title":"Nutrition [Internet]."},{"issue":"2","key":"pone.0293865.ref082","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jped.2017.04.006","article-title":"Aggregation of risk indicators to cardiometabolic and musculoskeletal health in Brazilian adolescents in the periods 2008\/09 and 2013\/14","volume":"94","author":"AR Gaya","year":"2017","journal-title":"Jornal de Pediatria."},{"key":"pone.0293865.ref083","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.numecd.2010.06.001","article-title":"Chronic inflammation is associated with overweight in Colombian school children.","volume":"22","author":"D Gilbert-Diamond","year":"2012","journal-title":"Nutrition, Metabolism and Cardiovascular Disease [Internet]."},{"key":"pone.0293865.ref084","first-page":"33","article-title":"Distribution of HDL\u2013cholesterol and non-HDL\u2013cholesterol in Brazilian children and adolescents\u2013The Floripa study.","volume":"21","author":"I Giuliano","year":"2011"},{"key":"pone.0293865.ref085","doi-asserted-by":"crossref","DOI":"10.5935\/abc.20190209","article-title":"Evaluation of Lipid Profiles of Children and Youth from Basic Health Units in Campinas, SP, Brazil: A Cross-Sectional Laboratory Study.","author":"\u00c9 Gomes","year":"2019","journal-title":"Arquivos Brasileiros de Cardiologia [Internet]."},{"key":"pone.0293865.ref086","article-title":"Food consumption pattern and obesity in preschool children in Feira de Santana, Bahia, Brazil\/Padrao de consumo alimentar e obesidade em pre-escolares, Feira de Santana, Bahia.","author":"S Gomes K de","year":"2017","journal-title":"Revista de Nutri\u00e7\u00e1o [Internet]"},{"key":"pone.0293865.ref087","article-title":"Television viewing and its association with overweight in Colombian children: Results from the 2005 National Nutrition Survey: A cross sectional study.","author":"LF Gomez","year":"2007","journal-title":"International Journal of Behavioral Nutrition and Physical Activity"},{"issue":"5","key":"pone.0293865.ref088","first-page":"788","article-title":"Obesity and dental caries among preschool children in Brazil.","volume":"10","author":"A Granville-Garcia","year":"2008","journal-title":"Revista salud p\u00fablica [Internet]"},{"issue":"4","key":"pone.0293865.ref089","article-title":"Maia M de F de M, Tolentino TM. Low body weight\/thinness, overweight and obesity of children and adolescents from a Brazilian region of low economic status.","volume":"31","author":"D Guedes","year":"2013","journal-title":"Revista Paulista de Pediatria [Internet]."},{"key":"pone.0293865.ref090","first-page":"18","article-title":"Correlation of the assessment of total body fat by bioimpedance with formula of anthropometric prediction in school age children","author":"M Guevara Castillo","year":"2018","journal-title":"In: XVI Seminario Internacional de Salud Alimentaci\u00f3n y Nutrici\u00f3n HUmana"},{"issue":"1","key":"pone.0293865.ref091","article-title":"Estado nutricional de preescolares asistentes a la Junta Nacional de Jardines Infantiles de Chile: evaluaci\u00f3n de la concordancia entre indicadores antopom\u00e9tricos de obesidad y obesidad central.","volume":"59","author":"Y Guti\u00e9rez-G\u00f3mez","year":"2009","journal-title":"Archivos Latinoamericanos de Nutrici\u00f3n [Internet]."},{"issue":"6","key":"pone.0293865.ref092","article-title":"The influence of socioeconomic status and age on the prevalence of overweight and obesity among 5 to 10\u2010year\u2010old children in Curitiba, Brazil.","volume":"32","author":"E H\u00e9rcules","year":"2020","journal-title":"American Journal of Human Biology [Internet]."},{"issue":"1","key":"pone.0293865.ref093","article-title":"Excess protein in poverty settings: The paradox of overweight in colombian children.","volume":"44","author":"OF Herr\u00e1n","year":"2017","journal-title":"Excess protein in poverty settings: The paradox of overweight in colombian children"},{"key":"pone.0293865.ref094","article-title":"FACTORES QUE INFLUYEN SOBRE LA CAPACIDAD DE RESISTENCIA AER\u00d3BICA, DETERMINADO POR EL CONSUMO M\u00c1XIMO DE OX\u00cdGENO EN LOS ADOLESCENTES QUE CURSAN LOS TRES NIVELES DE BACHILLERATO EN EL COLEGIO NACIONAL CUMBAY\u00c1 DURANTE EL PER\u00cdODO JUNIO- JULIO DEL A\u00d1O 2015. [T\u00edtulo de M\u00e9dico Cirujano].","author":"CV Herrera Sevilla","year":"2015","journal-title":"Pontificia Universidad Cat\u00f3lica del Ecuador"},{"issue":"1","key":"pone.0293865.ref095","first-page":"42","article-title":"Improvement in lipid profile after vitamin D supplementation in indigenous argentine school children","volume":"12","author":"V Hirschler","year":"2014","journal-title":"Cardiovascular & Hematological Agents in Medicinal Chemistry [Internet]."},{"key":"pone.0293865.ref096","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.clinbiochem.2012.04.020","article-title":"Lifestyle behaviors and dyslipidemia in Argentinean native versus urban children","volume":"45","author":"V Hirschler","year":"2012","journal-title":"Clinical Biochemistry [Internet]."},{"key":"pone.0293865.ref097","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jpeds.2008.06.036","article-title":"Inverse association between insulin resistance and frequency of milk consumption in low-income Argentinean school children","volume":"154","author":"V Hirschler","year":"2009","journal-title":"The Journal of Pediatrics [Internet]."},{"key":"pone.0293865.ref098","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.clinbiochem.2009.11.003","article-title":"Relationship between obesity and metabolic syndrome among Argentinean elementary school children","volume":"43","author":"V Hirschler","year":"2010","journal-title":"Clinical Biochemistry [Internet]."},{"issue":"4","key":"pone.0293865.ref099","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/dia.2015.0357","article-title":"Comparison between HDL-C levels in argentine indigenous children living at high altitudes and US children","volume":"18","author":"V Hirschler","year":"2016","journal-title":"Diabetes Technol Ther"},{"issue":"4","key":"pone.0293865.ref100","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1399-5448.2006.00183.x","article-title":"Do mothers of overweight Argentinean preschool children perceive them as such","volume":"7","author":"V Hirschler","year":"2006","journal-title":"Pediatric Diabetes"},{"key":"pone.0293865.ref101","first-page":"13","article-title":"Status of Dyslipidemia in Vitamin D Supplemented Argentinean Indigenous Children Versus A Non-supplemented Mixed Population Group.","author":"V Hirschler","year":"2015","journal-title":"Cardiovascular & Hematological Agents in Medicinal Chemistry"},{"key":"pone.0293865.ref102","first-page":"203","article-title":"Low vitamin D concentrations among indigenous Argentinean children living at high altitudes","volume":"14","author":"V Hirschler","year":"2013","journal-title":"Pediatric Diabetes"},{"issue":"3","key":"pone.0293865.ref103","article-title":"U. Factors associated with obesity in Brazilian children enrolled in the School Health Program: a case-control study.","volume":"30","author":"R Hon\u00f3rio","year":"2014","journal-title":"Nutrici\u00f3n Hospitalaria [Internet]"},{"key":"pone.0293865.ref104","article-title":"Early Life Effects of a Dual Burden Environment: Childhood Intestinal Health and Immune Function in Gal\u00e1pagos, Ecuador.","author":"KM Houck","year":"2017","journal-title":"University of North Carolina- Chapel Hill."},{"key":"pone.0293865.ref105","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/ajhb.22404","article-title":"The effects of market integration on childhood growth and nutritional status: The dual burden of under- and over-nutrition in the northern Ecuadorian amazon","volume":"25","author":"K Houck","year":"2013","journal-title":"American Journal of Human Biology"},{"key":"pone.0293865.ref106","article-title":"CONDICI\u00d3N F\u00cdSICA DE LOS ADOLESCENTES WAY\u00daU.","author":"G. Iguar\u00e1n Kohen","year":"2015","journal-title":"Universidad Santo Tomas"},{"issue":"2","key":"pone.0293865.ref107","first-page":"29","article-title":"Factores de riesgo relacionados con la obesidad en estudiantes universitarios de reciente ingreso de la escuela de medicina de la Universidad del Zulia.","volume":"8","author":"P Inciarte","year":"2013","journal-title":"Revista Latinoamericana de Hipertensi\u00f3n [Internet]"},{"key":"pone.0293865.ref108","article-title":"Peri-Urban, but Not Urban, Residence in Bolivia Is Associated with Higher Odds of Co-Occurrence of Overweight and Anemia among Young Children, and of Households with an Overweight Woman and Stunted Child","author":"A Jones","year":"2018","journal-title":"Journal of Nutrition [Internet]."},{"key":"pone.0293865.ref109","first-page":"2014","article-title":"School-based obesity prevention intervention in Chilean children: effective in controlling, but not reducing obesity","author":"J Kain","year":"2014","journal-title":"Journal of Obesity [Internet]."},{"key":"pone.0293865.ref110","first-page":"63","article-title":"Obesity among preschool children of Santiago, Chile.","volume":"135","author":"J Kain","year":"2007","journal-title":"Rev Med Chile [Internet]"},{"key":"pone.0293865.ref111","first-page":"426","article-title":"The association of excessive growth with development of general and central obesity at 7 years of age in every period after birth in Chilean children","volume":"32","author":"J Kain","journal-title":"Nutrition [Internet]. 2016"},{"issue":"8","key":"pone.0293865.ref112","first-page":"1603","article-title":"Accelerated Growth in Early Life and Obesity in Preschool Chilean Children.","volume":"17","author":"J Kain","year":"2009","journal-title":"Epidemiology [Internet]"},{"issue":"9","key":"pone.0293865.ref113","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1017\/S136898000800428X","article-title":"Two-year controlled effectiveness trial of a school-based intervention to prevent obesity in Chilean children.","volume":"12","author":"J Kain","year":"2009","journal-title":"Public Health Nutrition [Internet]"},{"key":"pone.0293865.ref114","doi-asserted-by":"crossref","DOI":"10.9734\/BJMMR\/2014\/12185","article-title":"Differential Impact of Parental BMI and Diet on Overweight and Obesity in Young School Children in Southern Brazil [Internet].","volume":"4","author":"E Kupek","year":"2014","journal-title":"British Journal of Medicine & Medical Research."},{"issue":"6","key":"pone.0293865.ref115","first-page":"1175","article-title":"Lira PIC de, Menezes RCE de, Sequeira LA de S, Neto MA de A, Andrade SLLS de, Filho MB. Overweight in children and adolescents in Pernambuco State, Brazil: prevalence and determinants.","volume":"28","author":"VS Leal","year":"2012","journal-title":"Cadernos de Saude Publica [Internet]."},{"issue":"1","key":"pone.0293865.ref116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41110-017-0030-5","article-title":"Perceptions of neighborhood environments and their association with overweight in children, adolescents, and caretakers in a medium-sized city in Brazil.","volume":"42","author":"MA Leite","year":"2017","journal-title":"Nutrire"},{"key":"pone.0293865.ref117","article-title":"PREVALENCIA DE OBESIDAD EN PACIENTES PEDIATRICOS ATENDIDOS EN EL HOSPITAL MINSA II-2 TARAPOTO Y HOSPITAL ESSALUD II-2 TARAPOTO Y SU RELACION CON LA CIRCUNFERENCIA ABDOMINAL, PERIODO JULIO-NOVIEMBRE 2015.","author":"YD Linares Herrera","year":"2017","journal-title":"Universidad Nacional de San Mart\u00edn"},{"issue":"11","key":"pone.0293865.ref118","first-page":"834","article-title":"Letter to the Editor Obesity, Body Fat Distribution, and Physical Activity in School-age Children: an Urban and Rural Comparison in Valpara\u00edso, Chile","volume":"29","author":"PA Lizana","year":"2016","journal-title":"Biomed Environ Sci [Internet]."},{"issue":"2","key":"pone.0293865.ref119","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1017\/S136898001200362X","article-title":"Birth weight and obesity risk at first grade of high school in a non-concurrent cohort of Chilean children.","volume":"16","author":"S Loaiza","year":"2012","journal-title":"Public Health Nutrition [Internet]."},{"key":"pone.0293865.ref120","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1017\/S0007114514002840","article-title":"BMI gain and insulin resistance among school-aged children: a population-based longitudinal study in the Brazilian Amazon","volume":"112","author":"BH Louren\u00e7o","year":"2014","journal-title":"British Journal of Nutrition [Internet]."},{"issue":"7","key":"pone.0293865.ref121","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1017\/S1368980011000462","article-title":"Overweight, asthma symptoms, atopy and pulmonary function in children of 4\u201312 years of age: findings from the SCAALA cohort in.","volume":"14","author":"S Matos","year":"2011","journal-title":"Public Health Nutrition [Internet]."},{"key":"pone.0293865.ref122","author":"AE Morillo Silva","year":"2017","journal-title":"Relaci\u00f3n entre el consumo del calcio y la composici\u00f3n corporal en adolescentes"},{"issue":"1","key":"pone.0293865.ref123","doi-asserted-by":"crossref","DOI":"10.1186\/s12863-016-0402-5","article-title":"Cardio-metabolic parameters are associated with genetic admixture estimates in a pediatric population from Colombia","volume":"17","author":"AM Mu\u00f1oz","year":"2016","journal-title":"BMC Genetics"},{"issue":"3","key":"pone.0293865.ref124","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1399-5448.2010.00710.x","article-title":"Cardiometabolic risk factors as apolipoprotein B, triglyceride\/HDL-cholesterol ratio and C-reactive protein, in adolescents with and without obesity: Cross-sectional study in middle class suburban children","volume":"12","author":"C Musso","year":"2011","journal-title":"Pediatric Diabetes"},{"key":"pone.0293865.ref125","article-title":"Chemistry LVC, 2006 U. Evaluation of lipid metabolism on 2.267 Brazilian outpatient children.","author":"L Naves","year":"2006","journal-title":"Clinical Chemistry [Internet]."},{"key":"pone.0293865.ref126","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3177\/jnsv.62.73","article-title":"Elevated Serum Retinol and Low Beta-Carotene but not Alpha-Tocopherol Concentrations Are Associated with Dyslipidemia in Brazilian Adolescents.","volume":"62","author":"M Neyla De Lima Albuquerque","year":"2016","journal-title":"J Nutr Sci Vitaminol"},{"issue":"4","key":"pone.0293865.ref127","doi-asserted-by":"crossref","first-page":"640","DOI":"10.17843\/rpmesp.2016.334.2546","article-title":"Frecuencia de s\u00edndrome metab\u00f3lico en residentes de una regi\u00f3n andina del Per\u00fa.","volume":"33","author":"JA Ninatanta-Ortiz","year":"2016","journal-title":"Revista Peruana de Medicina Experimental y Salud P\u00fablica [Internet]."},{"issue":"3","key":"pone.0293865.ref128","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/eurpub\/ckr067","article-title":"Breastfeeding and obesity in Brazilian children","volume":"22","author":"J Novaes","year":"2011","journal-title":"European Journal of Public Health [Internet"},{"key":"pone.0293865.ref129","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.nut.2018.03.001","article-title":"Association of the FTO fat mass and obesity\u2013associated gene rs9939609 polymorphism with rewarding value of food and eating behavior in Chilean children.","volume":"54","author":"AM Obreg\u00f3n Rivas","year":"2018","journal-title":"Nutrition [Internet]."},{"key":"pone.0293865.ref130","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1123\/jpah.2014-0024","article-title":"Colombian Children With Overweight and Obesity Need Additional Motivational Support at School to Perform Health-Enhancing Physical Activity Progression of physical activity assessment methodology View project","volume":"12","author":"P Olaya-Contreras","year":"2015","journal-title":"Article in Journal of Physical Activity & Health [Internet]."},{"issue":"2","key":"pone.0293865.ref131","article-title":"CO179. MEDIDAS ANTROPOM\u00c9TRICAS E DE COMPOSI\u00c7\u00c3O CORPORAL COMO PREDITORES DE RISCO CARDIOVASCULAR E DA S\u00cdNDROME METAB\u00d3LICA EM ADOLESCENTES.","volume":"65","author":"O Oliveira Pani","year":"2015","journal-title":"Archivos Latinoamericanos de Nutricion [Internet]"},{"issue":"235","key":"pone.0293865.ref132","article-title":"Influence of the family nucleus on obesity in children from northeastern Brazil: A cross-sectional study.","volume":"7","author":"A Oliveira","year":"2007","journal-title":"BMC Public Health [Internet]"},{"issue":"3","key":"pone.0293865.ref133","article-title":"Short sleep and low milk intake are associated with obesity in a community of school aged children from Argentina","volume":"31","author":"AB Orden","year":"2019","journal-title":"American Journal of Human Biology [Internet]."},{"issue":"11","key":"pone.0293865.ref134","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1017\/S136898001200095X","article-title":"Variations in estimates of underweight, stunting, wasting, overweight and obesity in children from Argentina comparing three growth charts.","volume":"15","author":"G Padula","year":"2012","journal-title":"Public Health Nutrition [Internet]"},{"issue":"4","key":"pone.0293865.ref135","first-page":"583","article-title":"Overweight, obesity and chronic malnutrition in 6 to 9 year-old children in Peru, 2009\u20132010.","volume":"30","author":"J Pajuelo-Ram\u00edrez","year":"2013","journal-title":"Rev Peru Med Exp Salud Publica [Internet]"},{"issue":"2","key":"pone.0293865.ref136","first-page":"222","article-title":"Prevalence of overweight and obesity among children under five years in Peru 2007\u20132010.","volume":"28","author":"J Pajuelo-Ram\u00edrez","year":"2011","journal-title":"Rev Peru Med Exp Salud Publica [Internet]."},{"issue":"1","key":"pone.0293865.ref137","first-page":"42","article-title":"Children\u2019s eating behavior: comparison between normal and overweight children from a school in Pelotas, Rio Grande do Sul, Brazil.","volume":"33","author":"D Passos","year":"2015","journal-title":"Revista Paulista de Pediatria [Internet]."},{"key":"pone.0293865.ref138","article-title":"Early determinants of childhood obesity: What factors contribute to its development simultaneously in Uruguayan children 6\u201323 months.","author":"F Peregalli","year":"2013","journal-title":"Annals of Nutrition and Metabolism"},{"issue":"3","key":"pone.0293865.ref139","first-page":"236","article-title":"Obesity and its association with other cardiovascular risk factors in school children in Itapetininga, Brazil.","volume":"93","author":"A Pereira","year":"2009","journal-title":"Arquivos Brasileiros de Cardiologia [Internet]."},{"issue":"1","key":"pone.0293865.ref140","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/tropej\/fms035","article-title":"Nutritional status and lipid profile of young children in Brazil","volume":"59","author":"J Pereira","year":"2013","journal-title":"Journal of Tropical Pediatrics [Internet]."},{"key":"pone.0293865.ref141","first-page":"1","article-title":"Birth weight, weight gain, and obesity among children in uruguay: a prospective study since birth.","volume":"39","author":"I Pereyra","year":"2021","journal-title":"Rev Paul Pediatr [Internet]"},{"key":"pone.0293865.ref142","article-title":"Valoraci\u00f3n del bajo peso, sobrepeso y obesidad en los estudiantes del Colegio Nacional Manuel C\u00f3rdova Galarza del cant\u00f3n Cuenca 2010\u20132011 [Internet].","author":"A Pinc\u00f3n","year":"2011"},{"key":"pone.0293865.ref143","first-page":"385","article-title":"Lipid and apoprotein AI and B-100 levels in school children school from five central-eastern provinces of Colombia.","volume":"27","author":"E Poveda","year":"2007","journal-title":"Biom\u00e9dica [Internet]"},{"issue":"2","key":"pone.0293865.ref144","first-page":"1","article-title":"Inqu\u00e9rito epidemiol\u00f3gico em escolares: Determinantes e preval\u00eancia de fatores de risco cardiovascular.","volume":"32","author":"T Quadros","year":"2016","journal-title":"Cadernos de Saude Publica [Internet]."},{"key":"pone.0293865.ref145","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpeds.2017.05.065","article-title":"Cycling to School and Body Composition, Physical Fitness, and Metabolic Syndrome in Children and Adolescents","volume":"188","author":"R Ram\u00edrez-V\u00e9lez","year":"2017","journal-title":"Journal of Pediatrics [Internet]."},{"issue":"97","key":"pone.0293865.ref146","article-title":"Factors associated with active commuting to school by bicycle from Bogot\u00e1, Colombia: The FUPRECOL study","volume":"42","author":"R Ram\u00edrez-V\u00e9lez","year":"2016","journal-title":"Italian Journal of Pediatrics"},{"issue":"1","key":"pone.0293865.ref147","doi-asserted-by":"crossref","first-page":"21","DOI":"10.14306\/renhyd.19.1.123","article-title":"Sobrepeso y obesidad en escolares y adolescentes del \u00e1rea urbana de la ciudad de Riobamba, Ecuador.","volume":"19","author":"P Ramos-Padilla","year":"2015","journal-title":"Revista Espanola de Nutricion Humana y Dietetica"},{"issue":"1","key":"pone.0293865.ref148","doi-asserted-by":"crossref","first-page":"30","DOI":"10.36104\/amc.2017.752","article-title":"Factores de riesgo cardiovascular en adolescentes de una ciudad del Paraguay.","volume":"42","author":"RE Real Delor","year":"2017","journal-title":"Acta M\u00e9dica Colombiana"},{"key":"pone.0293865.ref149","first-page":"1228","article-title":"Anthropometric indices; predictors of dyslipidemia in children and adolescents from north of Brazil.","volume":"27","author":"SA Ribas","year":"2012","journal-title":"Nutrici\u00f3n Hospitalaria [Internet]."},{"issue":"6","key":"pone.0293865.ref150","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/ipd.12292","article-title":"Overweight, obese, underweight, and frequency of sugar consumption as risk indicators for early childhood caries in Brazilian preschool children.","volume":"27","author":"C Ribeiro","year":"2017","journal-title":"Paediatric Dentistry [Internet]"},{"issue":"3","key":"pone.0293865.ref151","first-page":"1","article-title":"Prevalence of overweight and obesity and central adiposity indexes among school-aged children in Santa Catarina, Brazil.","volume":"12","author":"G Ricardo","year":"2009","journal-title":"Rev Bras Epidemiol [Internet]"},{"issue":"1","key":"pone.0293865.ref152","article-title":"Metabolic syndrome in overweight children from the city of Botucatu-So Paulo State-Brazil: Agreement among six diagnostic criteria.","volume":"2","author":"AEM Rinaldi","year":"2010","journal-title":"Diabetology and Metabolic Syndrome"},{"key":"pone.0293865.ref153","article-title":"Sobrepeso-obesidad y factores de riesgo cardiometab\u00f3lico en ni\u00f1os y adolescentes de la ciudad de M\u00e9rida, Venezuela.","author":"Y Rinc\u00f3n","year":"2015","journal-title":"Investigacion Cl\u00ednica"},{"issue":"1","key":"pone.0293865.ref154","article-title":"Metabolic syndrome risk factors in overweight, obese, and extremely obese brazilian adolescents","volume":"12","author":"ACB Rizzo","year":"2013","journal-title":"Nutrition Journal"},{"key":"pone.0293865.ref155","author":"D. Rodrigues-Bezerra","year":"2016"},{"issue":"3","key":"pone.0293865.ref156","first-page":"228","article-title":"Prevalence of overweight and obesity in children and adolescents in a healthcare unit from Canoas, Rio Grande do Sul, Brazil, and comparison of the nutritional.","volume":"20","author":"E Romagna","year":"2010","journal-title":"Sci Med [Internet]"},{"key":"pone.0293865.ref157","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4236\/ojepi.2012.23011","article-title":"\u201cQuito municipal schools\u201d cohort study: Baseline results","volume":"2","author":"N Romero-Sandoval","year":"2012","journal-title":"Open Journal of Epidemiology"},{"key":"pone.0293865.ref158","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.clinbiochem.2013.08.015","article-title":"Simultaneous prediction of hyperglycemia and dyslipidemia in school children in Santa Catarina State, Brazil based on waist circumference measurement","volume":"46","author":"N Rosini","year":"2013","journal-title":"Clinical Biochemistry [Internet]."},{"key":"pone.0293865.ref159","author":"E. Rossi","year":"2018"},{"issue":"6","key":"pone.0293865.ref160","first-page":"511","article-title":"Relaci\u00f3n entre el d\u00e9ficit de sue\u00f1o nocturno, el exceso de peso y las alteraciones metab\u00f3licas en adolescentes.","volume":"112","author":"N Ruiz","year":"2014","journal-title":"Archivos Argentinos de Pediatria"},{"key":"pone.0293865.ref161","first-page":"1","article-title":"Association between high prepregnancy body mass index, excess gestational weight gain, and poor breastfeeding with overweight in Chilean children 3 to 4.","volume":"77","author":"L Salazar-Guti\u00e9rrez","year":"2020"},{"key":"pone.0293865.ref162","article-title":"Prevalence of underweight, stunting, overweight and obesity: their evolution in children from Azampay (Catamarca, Argentina).","author":"S Salceda","year":"2013","journal-title":"Runa: archivos para las ciencias del hombre [Internet]."},{"key":"pone.0293865.ref163","article-title":"Prevalence of obesity in preschool children from five towns in S\u00e3o Paulo State, Brazil [Internet]","volume":"20","author":"Escuder MML Saldiva SRDM","year":"2004","journal-title":"Cadernos de Saude Publica"},{"issue":"9","key":"pone.0293865.ref164","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1017\/S1368980007352464","article-title":"Is overweight a risk factor for wheezing in pre-school children? A study in 14 Brazilian communities.","volume":"10","author":"S Saldiva","year":"2007","journal-title":"Public Health Nutrition [Internet]."},{"key":"pone.0293865.ref165","first-page":"1","article-title":"D Hedeker. Correlates of overweight in children and adolescents living at different altitudes: the Peruvian Health and Optimist Growth Study","author":"C Santos","year":"2019","journal-title":"Journal of Obesity [Internet]."},{"key":"pone.0293865.ref166","doi-asserted-by":"crossref","first-page":"978","DOI":"10.4067\/s0034-98872018000900978","article-title":"Alta prevalencia de trastornos nutricionales por exceso, resistencia insul\u00ednica y s\u00edndrome metab\u00f3lico en escolares de la comuna de Carahue, Regi\u00f3n de la Araucan\u00eda","volume":"146","author":"J Sapunar","year":"2018","journal-title":"Revista m\u00e9dica de Chile."},{"key":"pone.0293865.ref167","article-title":"CURSO DE EDUCA\u00c7\u00c3O F\u00cdSICA FATORES SOCIODEMOGR\u00c1FICOS ASSOCIADOS AO BAIXO N\u00cdVEL DE APTID\u00c3O F\u00cdSICA RELACIONADA \u00c0 SA\u00daDE EM ESCOLARES MONOGRAFIA DE GRADUA\u00c7\u00c3O.","author":"AP Sehn","year":"2016","journal-title":"UNiversidade de Santa Cruz."},{"issue":"19","key":"pone.0293865.ref168","first-page":"1","article-title":"Obesity and metabolic syndrome in children in Brazil: the challenge of lifestyle change.","volume":"98","author":"P Sentalin","year":"2019","journal-title":"Medicine [Internet]"},{"issue":"5","key":"pone.0293865.ref169","doi-asserted-by":"crossref","first-page":"363","DOI":"10.21037\/tp.2019.04.04","article-title":"Early evaluation of the metabolic syndrome in Bucaramanga, Colombia.","volume":"8","author":"N Serrano","year":"2019","journal-title":"Translational Pediatrics"},{"key":"pone.0293865.ref170","first-page":"1","article-title":"Prevalence of overweight and obesity and associated factors in school children and adolescents in a medium-sized Brazilian city.","volume":"73","author":"A Silva","year":"2018","journal-title":"Clinics [Internet]"},{"issue":"4","key":"pone.0293865.ref171","first-page":"529","article-title":"Overweight and obesity in five- to ten-year-old children benefited from Bolsa Fam\u00edlia Program in the State of Sergipe, Brazil.","volume":"29","author":"DAS Silva","year":"2011","journal-title":"Revista Paulista de Pediatria"},{"issue":"3","key":"pone.0293865.ref172","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00246-008-9326-9","article-title":"Undernutrition and obesity associated with high blood pressure in children and adolescents from jo\u00e3o pessoa, para\u00edba, Brazil.","volume":"30","author":"KS Silva","year":"2009","journal-title":"Pediatric Cardiology."},{"issue":"3","key":"pone.0293865.ref173","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jped.2013.09.003","article-title":"Secular trends and factors associated with overweight among Brazilian preschool children: PNSN-1989, PNDS-1996, and 2006\/07.","volume":"90","author":"J Silveira","year":"2014","journal-title":"Jornal de Pediatria [Internet]."},{"issue":"4","key":"pone.0293865.ref174","article-title":"Lipid profile from low socioeconomic level preschool children. Valencia, Venezuela.","volume":"54","author":"L Solano","year":"2003","journal-title":"Acta Cientifica Venezolana [Internet]."},{"issue":"1","key":"pone.0293865.ref175","first-page":"37","article-title":"Preval\u00eancia de obesidade, press\u00e3o arterial elevada e dislipidemia e seus fatores associados em crian\u00e7as e adolescentes de um munic\u00edpio amaz\u00f4nico, Brasil.","volume":"31","author":"J de Souza","year":"2021","journal-title":"J Hum Growth Dev [Internet]"},{"key":"pone.0293865.ref176","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.envres.2019.05.030","article-title":"Blood pressure after a heightened pesticide spray period among children living in agricultural communities in Ecuador","volume":"175","author":"JR Suarez-Lopez","year":"2019","journal-title":"Environmental Research"},{"issue":"4","key":"pone.0293865.ref177","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s12519-016-0008-z","article-title":"Prevalence of metabolic syndrome in children aged 5\u20139 years from southwest colombia: a cross-sectional study","volume":"12","author":"MF Suarez-Orteg\u00f3n","year":"2016","journal-title":"World Journal of Pediatrics"},{"key":"pone.0293865.ref178","author":"I. Tande da Silva","year":"2011"},{"key":"pone.0293865.ref179","article-title":"Relations Between obesity and signals of depression a sample of brazilian children and adolescents.","author":"L. Tardivo","year":"2013","journal-title":"European Child and Adolescent Psychiatry"},{"issue":"2","key":"pone.0293865.ref180","first-page":"171","article-title":"Prevalence and factors associated with overweight and obesity in Peruvian primary school children.","volume":"20","author":"C Tarqui-Mamani","year":"2018","journal-title":"Rev Salud P\u00fablica [Internet]"},{"key":"pone.0293865.ref181","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S0007114518002738","article-title":"Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with anthropometric characteristics in South Brazilian children and adolescents","volume":"121","author":"PF Todendi","year":"2019","journal-title":"British Journal of Nutrition"},{"issue":"1","key":"pone.0293865.ref182","article-title":"Geographic differences in overweight and obesity prevalence in Peruvian children, 2010\u20132015.","volume":"18","author":"JS Torres-Roman","year":"2018","journal-title":"BMC Public Health [Internet]."},{"key":"pone.0293865.ref183","first-page":"1252","article-title":"Determinants of Childhood Obesity in Children from Different Socioeconomic Backgrounds in Brazil","volume":"44","author":"GG Torres","year":"2015","journal-title":"International Journal of Epidemiology [Internet]."},{"key":"pone.0293865.ref184","first-page":"S94","article-title":"353-P Malnutrition and obesity in Brazilian school children","author":"A Toso","journal-title":"European Journal of Parenternal and Enteral Nutrition [Internet]."},{"key":"pone.0293865.ref185","first-page":"1395","article-title":"Frequency of obesity and overweight among school age children living in southern Chile.","volume":"138","author":"N Ulloa","year":"2010","journal-title":"Rev Med Chile [Internet]"},{"issue":"1","key":"pone.0293865.ref186","first-page":"48","article-title":"Prevalence of overweight and obesity among children of public schools in the city of Jundia\u00ed, S\u00e3o Paulo, Brazil.","volume":"26","author":"A Vanzelli","year":"2008","journal-title":"Rev Paul Pediatr [Internet]"},{"key":"pone.0293865.ref187","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2013.05.021","article-title":"Physical activity and cardiometabolic risk in male children and adolescents: The Balcarce study","volume":"93","author":"J Verona","year":"2013","journal-title":"Life Sciences"},{"issue":"4","key":"pone.0293865.ref188","article-title":"Overweight and Obesity Related to Food Consumption and Physical Activity inSchool Children aged 9\u201314, ofState Educational Institutions in Cerro Colorado District.","volume":"11","author":"K Villalba-Condori","year":"2019","journal-title":"International Journal of Pharmaceutical Research [Internet]."},{"key":"pone.0293865.ref189","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.2147\/DMSO.S246061","article-title":"Overweight and Obesity in Children and Adolescents and Frequency of Type 2 Diabetes Mellitus and Glucose Intolerance: A Study in Public School in Brazil","volume":"13","author":"M Zaccarelli-Marino","year":"2020","journal-title":"Diabetes, Metabolic Syndrome and Obesity: Targets ad Therapy [Internet]."},{"issue":"1","key":"pone.0293865.ref190","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/ijpo.12113","article-title":"Validation of obesity susceptibility loci identified by genome\u2010wide association studies in early childhood in South Brazilian children.","volume":"12","author":"MR Zandon\u00e1","year":"2017","journal-title":"Pediatric Obesity [Internet]"},{"issue":"1","key":"pone.0293865.ref191","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1559-4572.2008.00034.x","article-title":"Prevalence and significance of cardiometabolic risk factors in children with type 1 diabetes","volume":"4","author":"S Krishnan","year":"2009","journal-title":"Journal of the CardioMetabolic Syndrome"},{"issue":"10113","key":"pone.0293865.ref192","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1016\/S0140-6736(17)32129-3","article-title":"Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128\u00b79 million children, adolescents, and adults","volume":"390","author":"J Bentham","year":"2017","journal-title":"The Lancet"},{"key":"pone.0293865.ref193","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jpeds.2005.08.057","article-title":"Pediatric metabolic syndrome: Smoke and mirrors or true magic","volume":"148","author":"E. Goodman","year":"2006","journal-title":"Journal of Pediatrics. Mosby"},{"issue":"3","key":"pone.0293865.ref194","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1210\/jc.2013-3531","article-title":"The typology of metabolic syndrome in the transition to adulthood","volume":"99","author":"T Stanley","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"2","key":"pone.0293865.ref195","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1542\/peds.2006-1699","article-title":"2007 undefined. Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics Follow-up Study","volume":"120","author":"J Morrison","year":"2007","journal-title":"Pediatrics"},{"issue":"1","key":"pone.0293865.ref196","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1089\/chi.2015.0136","article-title":"Cardiometabolic Risk Factors among Severely Obese Children and Adolescents in the United States, 1999\u20132012.","volume":"12","author":"L Li","year":"2016","journal-title":"Childhood Obesity [Internet]."},{"key":"pone.0293865.ref197","article-title":"Report on Commission on Ending Childhood Obesity [Report accessed on the Internet].","author":"World Health Organization","year":"2016","journal-title":"World Health Organization"},{"issue":"6","key":"pone.0293865.ref198","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.pcl.2009.09.008","article-title":"Undernutrition and Obesity in Indigenous Children: Epidemiology, Prevention, and Treatment","volume":"56","author":"AR Ruben","year":"2009","journal-title":"Pediatric Clinics of North America"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0293865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:40:42Z","timestamp":1700678442000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0293865"}},"subtitle":[],"editor":[{"given":"Patricia","family":"Khashayar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":198,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0293865","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,22]]}}}