{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:30:30Z","timestamp":1776382230981,"version":"3.51.2"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022752","name":"MSD Sharp & Dohme GmbH","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100022752","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Congenital cytomegalovirus (cCMV) infection can have a broad range of manifestations. This study aimed to assess cCMV-associated sequelae and healthcare resource utilization (HCRU) in infants during the first year of life in Germany.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A retrospective, controlled cohort study using German claims data from the Institute for Applied Health Research Berlin (InGef) database was conducted. cCMV-associated sequelae and HCRU during the first year of life were assessed by matching (1:60) infants with at least one inpatient\/outpatient cCMV diagnosis (ICD-10-GM: P35.1) \u226490 days after birth (cCMV<jats:sub>90<\/jats:sub> cohort) and infants with at least one inpatient cCMV diagnosis plus specific sequelae \u226421 days after birth (cCMV<jats:sub>21-S<\/jats:sub>) to infants without cCMV or CMV (ICD-10-GM: B25) diagnosis (control group), respectively. Outcomes were analyzed during the first 365 days of life.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Between 2014\u20132018, we identified 54 newborns for cCMV<jats:sub>90<\/jats:sub> and 24 newborns for cCMV<jats:sub>21-S<\/jats:sub> cohort. Compared to the 3,240 and 1,440 controls, respectively, more cCMV<jats:sub>90<\/jats:sub> infants (83.3% vs. 41.9%, p&lt;0.01) presented with at least one sequela during the first year of life, including intrauterine growth retardation (42.6% vs. 5.3%, p&lt;0.01), sensorineural hearing loss (SNHL) to deafness (38.9% vs. 2.2%, p&lt;0.01), and motor development disorders (33.3% vs. 10.9%, p&lt;0.01). Further, 13.0% of cCMV<jats:sub>90<\/jats:sub> infants (vs. 2.3%, p&lt;0.01) suffered from visual impairment. In cCMV<jats:sub>21-S<\/jats:sub> cohort, intrauterine growth retardation (79.2% vs. 6.0%, p&lt;0.01), prematurity (54.2% vs. 7.3%, p&lt;0.01), and motor development disorders (50.0% vs. 11.0%, p&lt;0.01) were the most frequent sequelae. Infants in the cCMV<jats:sub>90<\/jats:sub> and cCMV<jats:sub>21-S<\/jats:sub> cohort had, on average, 7.3 times and 9.5 times more hospitalizations and 2.0 times and 2.1 times more outpatient physician visits than their respective controls (p&lt;0.01). Hospitalized infants with cCMV stayed, on average, significantly longer in hospital compared to their controls (cCMV<jats:sub>90<\/jats:sub> cohort: 30.3 days vs. 9.0 days, p&lt;0.01; cCMV<jats:sub>21-S<\/jats:sub> cohort: 46.5 days vs. 9.3 days, p&lt;0.01).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>cCMV-infection shows a considerable disease and healthcare burden during the first year of life. More than 80% of the identified newborns with cCMV suffered from at least one associated sequela during the first year of life, including long-term sequelae such as SNHL (40%) and visual impairment (13%). Additional steps for prevention of cCMV infection and associated sequelae as well as a comprehensive monitoring of disease burden are needed.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0293869","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T18:47:46Z","timestamp":1700160466000},"page":"e0293869","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Burden of sequelae and healthcare resource utilization in the first year of life in infants born with congenital cytomegalovirus (cCMV) infection in Germany: A retrospective statutory health insurance claims database analysis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-2039","authenticated-orcid":true,"given":"Marion","family":"de Lepper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Janina","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regine","family":"W\u00f6lle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim Maren","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Buxmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rangmar","family":"Goelz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Hamprecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Modrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Luzak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Reuschenbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"issue":"4","key":"pone.0293869.ref001","first-page":"45","article-title":"Primary Human Cytomegalovirus (HCMV) Infection in Pregnancy","volume":"114","author":"H Buxmann","year":"2017","journal-title":"Deutsches Arzteblatt international"},{"issue":"3","key":"pone.0293869.ref002","doi-asserted-by":"crossref","first-page":"e2034","DOI":"10.1002\/rmv.2034","article-title":"Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta-analysis","volume":"29","author":"M Zuhair","year":"2019","journal-title":"Reviews in medical virology"},{"issue":"7","key":"pone.0293869.ref003","doi-asserted-by":"crossref","first-page":"e0200267","DOI":"10.1371\/journal.pone.0200267","article-title":"Cytomegalovirus (CMV) seroprevalence in the adult population of Germany","volume":"13","author":"R Lachmann","year":"2018","journal-title":"PloS one"},{"issue":"8","key":"pone.0293869.ref004","doi-asserted-by":"crossref","first-page":"e2120736","DOI":"10.1001\/jamanetworkopen.2021.20736","article-title":"Congenital Cytomegalovirus Infection Burden and Epidemiologic Risk Factors in Countries With Universal Screening: A Systematic Review and Meta-analysis","volume":"4","author":"P Ssentongo","year":"2021","journal-title":"JAMA network open"},{"issue":"4","key":"pone.0293869.ref005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s15014-016-0766-z","article-title":"CMV-Infektion bei Neugeborenen\u2014eine Herausforderung","volume":"28","author":"A. 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