{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:33:29Z","timestamp":1791502409984,"version":"4.3.4"},"reference-count":103,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"F.I.G.","award":["IITR\/SRIC\/2741"],"award-info":[{"award-number":["IITR\/SRIC\/2741"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>In several research studies, the reactivation extinction paradigm did not effectively prevent the return of fear if administered without any intervention technique. Therefore, in this study, the authors hypothesized that playing music (high valence, low arousal) during the reconsolidation window may be a viable intervention technique for eliminating fear-related responses. A three-day auditory differential fear conditioning paradigm was used to establish fear conditioning. Participants were randomly assigned into three groups, i.e., one control group, standard extinction (SE), and two experimental groups, reactivation extinction Group (RE) and music reactivation extinction (MRE), of twenty participants in each group. Day 1 included the habituation and fear acquisition phases; on Day 2 (after 24 hours), the intervention was conducted, and re-extinction took place on Day 3. Skin conductance responses were used as the primary outcome measure. Results indicated that the MRE group was more effective in reducing fear response than the RE and SE groups in the re-extinction phase. Furthermore, there was no significant difference observed between SE and RE groups. This is the first study known to demonstrate the effectiveness of music intervention in preventing the return of fear in a healthy individual. Therefore, it might also be employed as an intervention strategy (non-pharmacological approach) for military veterans, in emotion regulation, those diagnosed with post-traumatic stress disorder, and those suffering from specific phobias.<\/jats:p>","DOI":"10.1371\/journal.pone.0293880","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T13:22:01Z","timestamp":1708521721000},"page":"e0293880","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preventing fear return in humans: Music-based intervention during reactivation-extinction 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McGaugh","year":"2002","journal-title":"Curr Opin Neurobiol"},{"key":"pone.0293880.ref004","first-page":"1","volume":"27","author":"JL McGaugh","year":"2004","journal-title":"THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES"},{"issue":"2","key":"pone.0293880.ref005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jpsychores.2005.06.074","article-title":"The perseverative cognition hypothesis: A review of worry, prolonged stress-related physiological activation, and health","volume":"60","author":"JF Brosschot","year":"2006","journal-title":"J Psychosom Res"},{"issue":"2","key":"pone.0293880.ref006","first-page":"120","article-title":"Mechanisms of fear extinction","volume":"12","author":"KM Myers","year":"2006","journal-title":"Mol Psychiatry 2007 122"},{"issue":"3","key":"pone.0293880.ref007","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cell.2011.10.009","article-title":"Molecular Mechanisms of Fear Learning and Memory","volume":"147","author":"JP Johansen","year":"2011","journal-title":"Cell"},{"issue":"10","key":"pone.0293880.ref008","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0006-3223(02)01546-9","article-title":"Context, ambiguity, and unlearning: sources of relapse after behavioral extinction","volume":"52","author":"ME Bouton","year":"2002","journal-title":"Biol Psychiatry"},{"issue":"5","key":"pone.0293880.ref009","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1101\/lm.77504","article-title":"Spontaneous Recovery","volume":"11","author":"RA Rescorla","year":"2004","journal-title":"Learn Mem"},{"key":"pone.0293880.ref010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brat.2014.04.006","article-title":"Maximizing exposure therapy: An inhibitory learning approach","volume":"58","author":"MG Craske","year":"2014","journal-title":"Behav Res 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long-term memory formation and storage","volume":"5","author":"CM Alberini","year":"2011","journal-title":"Front Behav Neurosci"},{"key":"pone.0293880.ref015","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.cortex.2020.04.017","article-title":"No persistent attenuation of fear memories in humans: A registeredreplication of the reactivation-extinction effect","volume":"129","author":"A Chalkia","year":"2020","journal-title":"Cortex"},{"issue":"3","key":"pone.0293880.ref016","first-page":"256","article-title":"Beyond extinction: erasing human fear responses and preventing the return of fear","volume":"12","author":"M Kindt","year":"2009","journal-title":"Nat Neurosci 2009 123"},{"issue":"1","key":"pone.0293880.ref017","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopsycho.2011.09.016","article-title":"Reconsolidation in a human fear conditioning study: A test of extinction as updating mechanism","volume":"92","author":"M Kindt","year":"2013","journal-title":"Biol Psychol"},{"issue":"7","key":"pone.0293880.ref018","doi-asserted-by":"crossref","first-page":"14308","DOI":"10.4088\/JCP.10r06218blu","article-title":"The Pharmacologic Treatment of Anxiety Disorders: A Review of Progress","volume":"71","author":"LN Ravindran","year":"2010","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"pone.0293880.ref019","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/jama.1973.03220280028007","article-title":"Adverse Reactions to Spironolactone: A Report From the Boston Collaborative Drug Surveillance Program","volume":"225","author":"DJ Greenblatt","year":"1973","journal-title":"JAMA"},{"issue":"2","key":"pone.0293880.ref020","first-page":"214","article-title":"Propranolol-induced depression and psychosis","volume":"4","author":"WA Parker","year":"1985","journal-title":"Clin Pharm"},{"issue":"7277","key":"pone.0293880.ref021","first-page":"49","article-title":"Preventing the return of fear in humans using reconsolidation update mechanisms","volume":"463","author":"D Schiller","year":"2009","journal-title":"Nat 2009 4637277"},{"issue":"7","key":"pone.0293880.ref022","doi-asserted-by":"crossref","first-page":"e0129393","DOI":"10.1371\/journal.pone.0129393","article-title":"Disruption of Memory Reconsolidation Erases a Fear Memory Trace in the Human Amygdala: An 18-Month Follow-Up","volume":"10","author":"J Bj\u00f6rkstrand","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"pone.0293880.ref023","first-page":"1","article-title":"Extinction during memory reconsolidation blocks recovery of fear in adolescents","volume":"5","author":"DC Johnson","year":"2015","journal-title":"Sci Reports 2015 51"},{"key":"pone.0293880.ref024","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nlm.2014.02.012","article-title":"Involvement of GSK3\u03b2\/\u03b2-catenin signaling in the impairment effect of ketamine on spatial memory consolidation in rats","volume":"111","author":"H Liu","year":"2014","journal-title":"Neurobiol Learn Mem"},{"issue":"6","key":"pone.0293880.ref025","doi-asserted-by":"crossref","first-page":"e38849","DOI":"10.1371\/journal.pone.0038849","article-title":"Updating Fearful Memories with Extinction Training during Reconsolidation: A Human Study Using Auditory Aversive Stimuli","volume":"7","author":"JP Oyarz\u00fan","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"pone.0293880.ref026","first-page":"1","article-title":"Preventing the Return of Fear Using Reconsolidation Update Mechanisms Depends on the Met-Allele of the Brain Derived Neurotrophic Factor Val66Met Polymorphism","volume":"19","author":"MK Asthana","year":"2016","journal-title":"Int J Neuropsychopharmacol"},{"issue":"November 2012","key":"pone.0293880.ref027","first-page":"36817","article-title":"Are fear memories erasable? -reconsolidation of learned fear with fear relevant and fearirrelevant stimuli","volume":"6","author":"A Golkar","year":"2012","journal-title":"Front Behav Neurosci"},{"issue":"1\u20132","key":"pone.0293880.ref028","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.psychres.2014.09.005","article-title":"Pharmacological blockade of memory reconsolidation in post-traumatic stress disorder: Three negative psychophysiological studies","volume":"225","author":"NE Wood","year":"2015","journal-title":"Psychiatry Res"},{"issue":"1","key":"pone.0293880.ref029","first-page":"1","article-title":"Demarcating the boundary conditions of memory reconsolidation: An unsuccessful replication","volume":"12","author":"LE Stemerding","year":"2022","journal-title":"Sci Reports 2022 121"},{"key":"pone.0293880.ref030","doi-asserted-by":"crossref","unstructured":"Wang S-H, Ostlund SB, Nader K, Balleine BW. Brief Communication Consolidation and Reconsolidation of Incentive Learning in the Amygdala. 2005;","DOI":"10.1523\/JNEUROSCI.4716-04.2005"},{"key":"pone.0293880.ref031","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nlm.2018.11.001","article-title":"Involvement of classical neurotransmitter systems in memory reconsolidation: Focus on destabilization","volume":"156","author":"CE Wideman","year":"2018","journal-title":"Neurobiol Learn Mem"},{"issue":"2","key":"pone.0293880.ref032","first-page":"446","article-title":"Disruptive Effect of Midazolam on Fear Memory Reconsolidation: Decisive Influence of Reactivation Time Span and Memory Age","volume":"34","author":"SG Bustos","year":"2008","journal-title":"Neuropsychopharmacol 2009 342"},{"key":"pone.0293880.ref033","doi-asserted-by":"crossref","unstructured":"Haubrich J. 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R. Battaglia","year":"2023","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"pone.0293880.ref040","unstructured":"Taylorlyn Mehnert by N, Roth E, Jennifer Fiore C, Moe A, Mansberger N. THE ROLE OF MUSIC IN THE TRAUMA NARRATIVE AND \"STORYTELLING\": PERSPECTIVES OF CLINICIANS. 2021;"},{"issue":"1","key":"pone.0293880.ref041","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-021-01155-7","article-title":"Prefrontal cortex, amygdala, and threat processing: Implications for PTSD","volume":"47","author":"M. Alexandra Kredlow","year":"2022","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"pone.0293880.ref042","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.nlm.2009.08.006","article-title":"Reconsolidation in humans opens up declarative memory to the entrance of new information","volume":"93","author":"Cecilia Forcato","year":"2010","journal-title":"Neurobiology of learning and memory"},{"issue":"6","key":"pone.0293880.ref043","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.tins.2015.04.007","article-title":"Reconsolidation and the regulation of plasticity: moving beyond memory","volume":"38","author":"R. P. Bonin","year":"2015","journal-title":"Trends in neurosciences"},{"key":"pone.0293880.ref044","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2431-12-2","article-title":"Randomised controlled trial of improvisational music therapy\u2019s effectiveness for children with autism spectrum disorders (TIME-A): Study protocol","volume":"12","author":"M Geretsegger","year":"2012","journal-title":"BMC Pediatr"},{"issue":"8","key":"pone.0293880.ref045","doi-asserted-by":"crossref","first-page":"e70156","DOI":"10.1371\/journal.pone.0070156","article-title":"The Effect of Music on the Human Stress Response","volume":"8","author":"M V. Thoma","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"pone.0293880.ref046","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"F Faul","year":"2007","journal-title":"Behav Res Methods"},{"issue":"April","key":"pone.0293880.ref047","doi-asserted-by":"crossref","first-page":"104201","DOI":"10.1016\/j.brat.2022.104201","article-title":"Stimulus diversity increases category-based fear generalization and the effect of intolerance of uncertainty","volume":"159","author":"M Fan","year":"2022","journal-title":"Behav Res Ther"},{"key":"pone.0293880.ref048","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fpsyt.2018.00117","article-title":"Beyond extinction: Prolonged conditioning and repeated threat exposure abolish contextual renewal of fear-potentiated startle discrimination but leave expectancy ratings intact","volume":"9","author":"A. Leer","year":"2018","journal-title":"Frontiers in Psychiatry"},{"issue":"5","key":"pone.0293880.ref049","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1080\/02699931.2018.1526167","article-title":"Generalisation of threat expectancy increases with time","volume":"33","author":"A. Leer","year":"2019","journal-title":"Cognition and Emotion"},{"issue":"1","key":"pone.0293880.ref050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0149-7189(95)00037-2","article-title":"Minimizing participant attrition in panel studies through the use of effective retention and tracking strategies: Review and recommendations","volume":"19","author":"K. M. Ribisl","year":"1996","journal-title":"Evaluation and Program Planning"},{"key":"pone.0293880.ref051","doi-asserted-by":"crossref","unstructured":"Lipp O V., Sheridan J, David ATS. Human_blink_startle_during_aversive_and.pdf. Vol. 20, Journal of Experimental Psychology. 1994. p. 380\u20139.","DOI":"10.1037\/\/0097-7403.20.4.380"},{"key":"pone.0293880.ref052","unstructured":"Verma, A., RD, S., & Asthana, M. K., (in press). Music Genre Preference of Non-Musicians. Under Review"},{"issue":"10","key":"pone.0293880.ref053","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jogoh.2019.07.007","article-title":"Effect of music in reducing patient anxiety during colposcopy: A systematic review and meta-analysis of randomized controlled trials","volume":"48","author":"AM Abdelhakim","year":"2019","journal-title":"J Gynecol Obstet Hum Reprod"},{"issue":"2","key":"pone.0293880.ref054","first-page":"4141","article-title":"Music Therapy and Labour Pain among Primigravida Women","volume":"7","author":"BP Magnaye","year":"2020","journal-title":"Eur J Mol Clin Med"},{"key":"pone.0293880.ref055","unstructured":"Whittemore J. A Study of Music: Music Psychology, Music Therapy, and Worship Music. 2019;"},{"issue":"5","key":"pone.0293880.ref056","first-page":"437","article-title":"Human Body Rhythms in the Development of Non-Invasive Methods of Closed-Loop Adaptive Neurostimulation","volume":"11","author":"A Fedotchev","year":"2021","journal-title":"J Pers Med 2021, Vol 11"},{"key":"pone.0293880.ref057","unstructured":"Lin O. Exploring therapeutic process through music therapy: the experience of an adult\" Third Culture Kid\". 2020;"},{"key":"pone.0293880.ref058","first-page":"107","article-title":"Musiktherapie mit> Elise<: Kann Klavierunterricht Therapie sein? Reproduzieren statt improvisieren?\/Music therapy with> Elise<. Can piano lessons be therapy? Reproducing instead of improvising?","volume":"41","author":"G. Kupski","year":"2020","journal-title":"Musik Umschau"},{"key":"pone.0293880.ref059","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.aip.2017.02.006","article-title":"The effect of specific music instrumentation on anxiety reduction in university music students: A feasibility study","volume":"54","author":"B. Matney","year":"2017","journal-title":"Arts Psychother"},{"issue":"2","key":"pone.0293880.ref060","first-page":"1111","article-title":"Effects of Music on Chronic Pain and Associated Mood Disorders in Rats","volume":"30","author":"X. Yang","year":"2020","journal-title":"Rev Cient\u00edfica la Fac Ciencias Vet"},{"issue":"1","key":"pone.0293880.ref061","article-title":"Music as Medicine: a Literature Review on the Effectiveness of Mozart\u2019s Music on Epilepsy","volume":"14","author":"S Yew","year":"2020","journal-title":"Intersect Stanford J Sci Technol Soc"},{"key":"pone.0293880.ref062","article-title":"14 Nonpharmacologic Management of Postsurgical Pain","volume":"128","author":"J Carter","year":"2018","journal-title":"Perioper Pain Manag Gen Plast Surg"},{"issue":"6","key":"pone.0293880.ref063","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1097\/SLA.0000000000003506","article-title":"The effect of perioperative music on medication requirement and hospital length of stay: a meta-analysis","volume":"272","author":"VX Fu","year":"2020","journal-title":"Ann Surg"},{"key":"pone.0293880.ref064","doi-asserted-by":"crossref","unstructured":"Bardekar AA, Gurjar AA. Study of Indian classical ragas structure and its influence on human body for music therapy. In: 2016 2nd International Conference on Applied and Theoretical Computing and Communication Technology (iCATccT). IEEE; 2016. p. 119\u201323.","DOI":"10.1109\/ICATCCT.2016.7911976"},{"key":"pone.0293880.ref065","unstructured":"Desai BU, Tandel KI, Patel RM. Essential Features Extraction from Aaroh and Avroh of Indian Classical Raag\u2013YAMAN. Int Res J Eng Technol (IRJET), https:\/\/www.irjet.net\/archives. 2020;7."},{"issue":"9","key":"pone.0293880.ref066","article-title":"Effect of camatic music and pranayama on depression and resilience in mild depressives","volume":"6","author":"AC Priyadarsini","year":"2015","journal-title":"Indian J Heal Wellbeing"},{"issue":"1","key":"pone.0293880.ref067","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/jdmimsu.jdmimsu_23_17","article-title":"Effect of music therapy in patients with moderate-to-severe traumatic brain injury","volume":"12","author":"BU Reddy","year":"2017","journal-title":"J Datta Meghe Inst Med Sci Univ"},{"issue":"4","key":"pone.0293880.ref068","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1037\/pmu0000192","article-title":"Music therapy for post-traumatic stress in adults: a theoretical review","volume":"27","author":"N Landis-Shack","year":"2017","journal-title":"Psychomusicology Music Mind, Brain"},{"issue":"3","key":"pone.0293880.ref069","first-page":"17","article-title":"Music therapy with bereaved youth: Expressing grief and feeling better","volume":"18","author":"K. McFerran","year":"2011","journal-title":"Prev Res"},{"issue":"3","key":"pone.0293880.ref070","first-page":"195","article-title":"What is medical music therapy in Islamic civilization?","volume":"8","author":"SNM Sufie","year":"2017","journal-title":"Int J Bus Soc Sci"},{"issue":"2","key":"pone.0293880.ref071","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/mtp\/miz003","article-title":"Therapeutic Uses of the Flute Within Music Therapy Practice","volume":"37","author":"CE Burns","year":"2019","journal-title":"Music Ther Perspect"},{"key":"pone.0293880.ref072","unstructured":"Loombe D, Tomlinson J, Oldfield A. Flute, accordion or clarinet?: Using the characteristics of our instruments in music therapy. Jessica Kingsley Publishers; 2015."},{"issue":"4","key":"pone.0293880.ref073","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/jmt\/thv019","article-title":"Performing theory: Playing in the music therapy discourse","volume":"52","author":"C. Kenny","year":"2015","journal-title":"J Music Ther"},{"key":"pone.0293880.ref074","doi-asserted-by":"crossref","unstructured":"Kenny C. The field of play: An ecology of being in music therapy. In: Voices: A World Forum for Music Therapy. 2014.","DOI":"10.15845\/voices.v14i1.737"},{"key":"pone.0293880.ref075","doi-asserted-by":"crossref","unstructured":"Loewy J. Integrating music, language and the voice in music therapy. In: Voices: A World forum for Music therapy. 2004.","DOI":"10.15845\/voices.v4i1.140"},{"key":"pone.0293880.ref076","doi-asserted-by":"crossref","unstructured":"Pfeifer E. Music-nature-therapy: Outdoor music therapy and other nature-related approaches in music therapy. In: Environmental Expressive Therapies. Routledge; 2017. p. 177\u2013203.","DOI":"10.4324\/9781315310459-10"},{"issue":"1","key":"pone.0293880.ref077","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/mtp\/14.1.21","article-title":"An overview of sound healing practices: Implications for the profession of music therapy","volume":"14","author":"BJ Crowe","year":"1996","journal-title":"Music Ther Perspect"},{"key":"pone.0293880.ref078","unstructured":"Humphries K. Healing Sound: Contemporary methods for Tibetan singing bowls. 2010;"},{"key":"pone.0293880.ref079","unstructured":"Perret D. Roots of musicality: Music therapy and personal development. Jessica Kingsley Publishers; 2005."},{"key":"pone.0293880.ref080","unstructured":"Shrestha S. How to heal with singing bowls: Traditional Tibetan healing methods. Sentient publications; 2009."},{"key":"pone.0293880.ref081","unstructured":"Dawson ME, Courtney CG. The Skin Conductance Response, Anticipation, and Decision-Making. 2011 [cited 2023 Jun 28]; https:\/\/www.researchgate.net\/publication\/232543769"},{"key":"pone.0293880.ref082","doi-asserted-by":"crossref","first-page":"103461","DOI":"10.1016\/j.brat.2019.103461","article-title":"A novel method to trigger the reconsolidation of fear memory","volume":"122","author":"Y Yang","year":"2019","journal-title":"Behav Res Ther"},{"key":"pone.0293880.ref083","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.biopsycho.2019.05.001","article-title":"Emotional enhancement of memory for neutral information: The complex interplay between arousal, attention, and anticipation","volume":"145","author":"JE Dunsmoor","year":"2019","journal-title":"Biol Psychol"},{"key":"pone.0293880.ref084","first-page":"3","article-title":"State-Trait Anxiety Inventory","author":"A. Wenzel","year":"2017","journal-title":"SAGE Encycl Abnorm Clin Psychol"},{"issue":"6","key":"pone.0293880.ref085","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1037\/0022-3514.54.6.1063","article-title":"Development and Validation of Brief Measures of Positive and Negative Affect: The PANAS Scales","volume":"54","author":"D Watson","year":"1988","journal-title":"J Pers Soc Psychol"},{"issue":"4","key":"pone.0293880.ref086","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1037\/bne0000245","article-title":"Preventing the return of fear memories with postretrieval extinction: A human study using a burst of white noise as an aversive stimulus","volume":"132","author":"J. Fernandez-Rey","year":"2018","journal-title":"Behavioral Neuroscience"},{"issue":"9","key":"pone.0293880.ref087","doi-asserted-by":"crossref","first-page":"e0221282","DOI":"10.1371\/journal.pone.0221282","article-title":"The effect of cathodal tDCS on fear extinction: A cross-measures study","volume":"14","author":"A. Ganho-\u00c1vila","year":"2019","journal-title":"PLoS One"},{"key":"pone.0293880.ref088","unstructured":"Steinfurth ECK, Kanen JW, Raio CM, Clem RL, Huganir RL, Phelps EA. Brief Communication Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans."},{"issue":"7","key":"pone.0293880.ref089","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3758\/BF03196892","article-title":"The cognitive processing of film and musical soundtracks","volume":"32","author":"MG Boltz","year":"2004","journal-title":"Mem Cogn"},{"issue":"1","key":"pone.0293880.ref090","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijpsycho.2005.04.007","article-title":"From emotion perception to emotion experience: Emotions evoked by pictures and classical music","volume":"60","author":"T Baumgartner","year":"2006","journal-title":"Int J Psychophysiol"},{"issue":"4","key":"pone.0293880.ref091","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/0305735604046096","article-title":"Intense emotional responses to music: a test of the physiological arousal hypothesis","volume":"32","author":"NS Rickard","year":"2004","journal-title":"Psychol Music"},{"issue":"2","key":"pone.0293880.ref092","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.nlm.2011.12.005","article-title":"Relaxing music counters heightened consolidation of emotional memory","volume":"97","author":"NS Rickard","year":"2012","journal-title":"Neurobiol Learn Mem"},{"issue":"4","key":"pone.0293880.ref093","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.ctim.2014.07.002","article-title":"Do asthmatics benefit from music therapy? A systematic review","volume":"22","author":"A. Sliwka","year":"2014","journal-title":"Complementary Therapies in Medicine"},{"issue":"1","key":"pone.0293880.ref094","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/jmt\/49.1.45","article-title":"An interpretative phenomenological analysis of an improvisational music therapy program for cancer patients","volume":"49","author":"M. Pothoulaki","year":"2012","journal-title":"Journal of Music Therapy"},{"issue":"5\u20136","key":"pone.0293880.ref095","first-page":"620","article-title":"Minimising preoperative anxiety with music for day surgery patients\u2014a randomised clinical trial","volume":"21","author":"CH Ni","year":"2012","journal-title":"J Clin Nurs"},{"issue":"4","key":"pone.0293880.ref096","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.aip.2012.05.002","article-title":"Music therapy techniques as predictors of change in mental health care","volume":"39","author":"K. M\u00f6ssler","year":"2012","journal-title":"The Arts in Psychotherapy"},{"key":"pone.0293880.ref097","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.aip.2015.02.003","article-title":"Music therapy in generalized anxiety disorder","volume":"44","author":"E. O. F. Guti\u00e9rrez","year":"2015","journal-title":"The Arts in Psychotherapy"},{"issue":"6","key":"pone.0293880.ref098","doi-asserted-by":"crossref","first-page":"e5865","DOI":"10.1371\/journal.pone.0005865","article-title":"Human fear conditioning and extinction in neuroimaging: a systematic review","volume":"4","author":"C. Sehlmeyer","year":"2009","journal-title":"PloS one"},{"issue":"7","key":"pone.0293880.ref099","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.neubiorev.2011.07.002","article-title":"Stress effects on memory: an update and integration","volume":"36","author":"L. Schwabe","year":"2012","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"1","key":"pone.0293880.ref100","doi-asserted-by":"crossref","first-page":"32","DOI":"10.7861\/clinmedicine.8-1-32","article-title":"How does the brain process music?","volume":"8","author":"J. Warren","year":"2008","journal-title":"Clinical Medicine"},{"key":"pone.0293880.ref101","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuroscience.2022.07.001","article-title":"Highly Demand Working Memory Intervention Weakens a Reactivated Threat Memory and the Associated Cognitive Biases","volume":"497","author":"S Picco","year":"2022","journal-title":"Neuroscience"},{"issue":"18","key":"pone.0293880.ref102","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1016\/j.cub.2020.06.091","article-title":"State-Dependent TMS over Prefrontal Cortex Disrupts Fear-Memory Reconsolidation and Prevents the Return of Fear","volume":"30","author":"S Borgomaneri","year":"2020","journal-title":"Curr Biol"},{"issue":"4","key":"pone.0293880.ref103","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci6040055","article-title":"No effect of cathodal transcranial direct current stimulation on fear memory in healthy human subjects","volume":"6","author":"A Mungee","year":"2016","journal-title":"Brain Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0293880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T13:22:54Z","timestamp":1708521774000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0293880"}},"subtitle":[],"editor":[{"given":"Simone","family":"Battaglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":103,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0293880","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]}}}