{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:10:32Z","timestamp":1740147032488,"version":"3.37.3"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UDG","award":["CONACYT- PROSNI-UDG-CUSUR,"],"award-info":[{"award-number":["CONACYT- PROSNI-UDG-CUSUR,"]}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["UNAM and project DGAPA, PAPPIT IN202121 for MDM."],"award-info":[{"award-number":["UNAM and project DGAPA, PAPPIT IN202121 for MDM."]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Pregnancy is a challenging metabolic and physiological condition. The aim of this study was to include a second demanding situation as a low protein\/high carbohydrate diet (LPHCD) to characterize the histological and functional responses of the maternal liver. It is unknown how the maternal liver responds during early and late pregnancy to LPHCD intake. We explored early pregnancy (3 and 8 gestational age, G) and late pregnancy (15 and 20 G). The results indicated that pregnant rats under control diet showed an evident presence of ballooned hepatocytes, lipid vesicles and edema at late pregnancy (15G); in contrast, pregnant rats under LPHCD showed similar pattern of histological modification but at early pregnancy (3G). Unexpectedly, the serum biomarkers didn\u2019t display functional alterations in either group, despite of the evident histological changes no liver malfunction was detected. We conclude that pregnant rats fed with control diet and experimental LPHCD, are subjected to metabolic and physiological conditions that impact the histopathological condition of the maternal liver. Control diet promoted the histological modifications during late pregnancy whereas LPCHCD advanced the onset of these changes. Further experiments are needed to explore the biochemical mechanisms that underlie these histological modifications. Our results are also an example of the resilience associated with the pregnancy: since no functional hepatic alterations accompanied the histopathological changes, another conclusion is that no evident pathological condition was detected in this nutritional protocol.<\/jats:p>","DOI":"10.1371\/journal.pone.0294062","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T19:39:42Z","timestamp":1704224382000},"page":"e0294062","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatocyte ballooning and steatosis in early and late gestation without liver malfunction: Effects of low protein\/high carbohydrate diet"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-1977","authenticated-orcid":true,"given":"M\u00f3nica","family":"Navarro-Meza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"D\u00edaz-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Alfonso","family":"Cruz-Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan Rafael","family":"Trinidad Gallardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Conchita","family":"Rodr\u00edguez Oseguera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola C.","family":"Bello-Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ericka Alejandra","family":"De Los R\u00edos-Arellano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"pone.0294062.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/387626","article-title":"Mitochondrial Roles and Cytoprotection in Chronic Liver Injury","volume":"2012","author":"ED Degli","year":"2012","journal-title":"Biochemistry Research International"},{"key":"pone.0294062.ref002","first-page":"3","article-title":"Liver problems in pregnancy: distinguishing normal from abnormal hepatic changes","volume":"3","author":"GT Everson","year":"1998","journal-title":"Medscape Womens Health"},{"key":"pone.0294062.ref003","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.611929","article-title":"Nutrition and Metabolic Adaptations in Physiological and Complicated Pregnancy: Focus on Obesity and Gestational Diabetes","volume":"11","author":"S Parrettini","year":"2020","journal-title":"Front Endocrinol"},{"issue":"1","key":"pone.0294062.ref004","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1385\/ENDO:19:1:43","article-title":"Lipid metabolism in pregnancy and its consequences in the fetus and newborn","volume":"19","author":"E. 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